Check out the new ISEH Ask the Experts Forum!
Every month the forum will feature 2 experts that will be answering questions and engaging in discussion with ISEH members. Access the forum here.
This month's experts:
David Kent has spent the last 10 years in the field of single hematopoietic stem cell biology. He undertook his PhD training with Professor Connie Eaves in Vancouver (2003-09) where his work focused on the intrinsic and extrinsic regulation of mouse hematopoietic stem cells. During this time, David developed the EPCR/SLAM sorting strategy for mouse HSCs (Blood 2009) and showed that HSCs could make cell fate choices before entering a first division and identified key molecules that associated with the self-renewal state (Blood 2008). David is currently based at the University of Cambridge with Professor Tony Green where he studies clonal stem cell blood disorders in mouse models as well as in primary patient samples. Thus far, his postdoctoral work has combined mathematical modelling with single stem cell assays to show that the JAK2V617F mutation affects stem and progenitor cells differently (PLoS Biology 2013) and showed that homozygous JAK2V617F mouse HSCs have a severe HSC defect despite displaying a robust disease phenotype (Li and Kent et al., Blood, 2014).
Brad Dykstra received his Ph.D. in Genetics in 2006 from
the University of British Columbia under the supervision of Prof. Connie Eaves
at the Terry Fox Laboratory in Vancouver, Canada. During his doctoral research,
Brad utilized single cell transplantation and other methods of clonal analysis
to study the intrinsic functional heterogeneity of the mouse hematopoietic stem
cell pool. From 2006 until 2011, Brad was a post-doctoral research fellow in
the laboratory of Prof. Gerald de Haan in Groningen, the Netherlands, where he
studied the effects of aging on hematopoietic stem cell function in mice. Brad
moved to Boston, USA in 2012 and joined the lab of Prof. Robert Sackstein at
Harvard Medical School as a senior post-doc. His current research focuses on the
role of adhesion molecule glycosylation on the homing and engraftment of human
hematopoietic stem cells.