ISEH - Society for Hematology and Stem Cells

Date: Tuesday, 4 June, 2013

Time: 0900 - 1000 Central Time Convert to your local time here.

Cost: Free to ISEH Members
$25 for non-members; free if you join ISEH now!

Moderator: David Kent, PhD, Department of Haematology, Cambridge Institute for Medical Research

Combinatorial Transcriptional
Control of Blood Stem and Progenitor Cells

Berthold Göttgens, PhD

Haematopoiesis represents one of the most tractable models of adult stem cell development and differentiation.

Transcription factor (TF) proteins have long been recognized as major regulators of blood stem cell development as well as the subsequent differentiation into the multiple mature haematopoietic lineages. However, it remains largely unknown how individual TFs are integrated into wider transcriptional regulatory networks, and how combinatorial TF interactions within these networks drive lineage specific gene expression programs.

During the webinar Dr. Göttgens will illustrate how his laboratory is using genome-scale resources to learn more about transcriptional control of blood cells. He will provide an overview of the nature of his laboratory recent and mostly unpublished data, and outline how they raise several fundamental questions concerning the functionality of transcription factor binding events, dynamic nature of cross-regulatory relationships and the interplay between the cellular environment and transcriptional programming.

Dr. Göttgens is a Professor of Molecular Haematology at the Cambridge Institute for Medical Research, University of Cambridge. His long-term research goal is to decipher the molecular hierarchy of transcriptional networks responsible for blood stem cell development, and how perturbation of these networks causes leukaemia. To date, he has published 130 papers, 111 of which are primary research publications.


Membership Connections	Experimental Hematology	42^nd Annual Scientific Meeting
ISEH programs and publications provide the tools for expansive understanding of cutting-edge methodologies from around the globe. The Society's e-newsletter, Connections in Hematology & Stem Cells, features news to help you connect. Click here to view the latest issues.	Experimental Hematology is the Society’s official journal. The journal is committed to publishing the latest research reports, reviews, letters to the editor, and abstracts of the annual meeting of the International Society for Experimental Hematology. Manuscripts relevant to all aspects of experimental hematology are welcome.	Save the date for the ISEH 42nd Annual Scientific Meeting to be held in Vienna, Austria, 22-25 August 2013. This exclusive, scientific meeting is the annual forum for the exchange and discussion of original, unpublished and significant research advances in the areas of hematology and stem cell biology.

ISEH Launches Inaugural Webinar Registration