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2017 Recording: Epigenetic Regulation of Normal and Malignant Hematopoiesis

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Hematopoietic stem cells (HSCs) with self-renewal and multi-lineage differentiation capacity are responsible to sustain blood cell production throughout the life-time of an individual. Multiple lines of research have implicated epigenetic regulation has as a central mechanism in establishing and maintaining HSC function. The term epigenetic regulation is used to describe heritable changes in gene expression that do not result from changes in the genome. Epigenetic marks, such as DNA methylation and post-translational histone modifications, create an epigenetic landscape leading to a specific transcriptional program characteristic of each cell type within an organism. In stem cells, this epigenetic landscape is not only responsible to maintain stem cell identity, but also coordinates lineage differentiation towards the different lineages. Furthermore, epigenetic dysregulation has also been established as an important mechanistic driver in several hematological malignancies, where mutations in several epigenetic modifiers are frequently found.

In the last decade, advances in next-generation sequencing have remarkably fueled or understanding on the role of the epigenome in hematopoiesis.


Webinar Presenters

Margaret Goodell, Baylor College of Medicine


Constanze Bonifer, Institute of Cancer and Genomic Sciences

Moderated by: 
Grant Challen, Washington University School of Medicine

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