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2019 Spring Webinar: Clonal Implications

Adult hematological malignancies such as acute myeloid leukemia are thought to arise through the gradual acquisition of oncogenic mutations within long-lived hematopoietic stem cells (HSCs). Genomic analysis of peripheral blood DNA has recently identified leukemia-associated genetic mutations within otherwise healthy individuals, an observation that is strongly associated with age. These genetic mutations are often found at high frequency within the peripheral blood, suggesting clonal dominance of the mutant (pre-leukemic) HSC. This clinical observation has been termed Clonal Hematopoiesis of Indeterminant Potential or CHIP, a state that increases both the risk of hematological malignancy as well as cardiovascular disease. In this ISEH New Investigator Committee Webinar, two leading figures in the discovery of Clonal Hematopoiesis and pre-leukemic HSCs, Drs. Sidd Jaiswal (Stanford University) and Liran Shlush (Weizmann Institute of Science), will share their seminal contributions to this new paradigm in hematology. This Webinar will be essential viewing for basic researchers and clinical hematologists alike.


Live Webinar: Thursday, 2 May at 11:00 US CDT - Check your local timezone here

Presented by

Liran Shlush, Weizmann Institute

Sidd Jaiswal, Stanford University

Moderated by

Isabel Beerman, National Institute of Health



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Most Recent:

2019 Winter Webinar: Deep dive into the niche: Follow up from the 2018 ISEH NI Tech Session!

This webinar will feature our four New Investigator Tech Session presenters from the ISEH 2018 Annual Meeting, and provide useful tips for performing state-of-the art imaging of the hematopoietic niche. Our presenters will share with us technical and intellectual input on how to characterize the nurturing microenvironment of normal and malignant cells.

Recording Now Available! See options below for member or non-member viewing.

Presented by

Mehmet Sacma, Ulm University

Sandra Pinho, Albert Einstein College of Medicine

Myriam Haltali, Imperial College London

Konstantinos Kokkaliaris, Harvard University

Moderated by

Heather O'Leary, Indiana University School of Medicine



ISEH Members: View past webinars here
Non-Members: View Webinars available for purchase here

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