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2019 Program
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 *Last updated 22 July 2019. Subject to change.


 Thursday, 22 August 2019

8:30 - 14:00

New Investigator Pre-meeting Workshop

8:30 - 15:30

Junior PI Grantmaking Workshop

14:15 - 14:45


First-Time Attendee Mingler

15:00 - 15:15

Welcome and Opening Remarks

15:15 - 16:00


Session 1: Donald Metcalf Award Lecture

David Scadden, Harvard Stem Cell Institute, USA (1001)


Sponsored by Leukaemia Foundation

16:15 - 18:00

Session 2: Hematopoietic Malignancies

Brian Huntly, Cambridge Stem Cell Institute, United Kingdom (1002)
Looping and leukaemia: alterations in DNA topology shape malignant transcriptional programmes

Ulrich Steidl, Albert Einstein College of Medicine - Montefiore Medical Center, USA (1003)
Understanding and Targeting the Stem Cell Origins of Myeloid Malignancies

Carl Walkley, St Vincent's Institute, Australia (1004)
How do Srsf2P95H mutations lead to myelodysplastic/myeloproliferative syndrome (MDS/MPN)?

Ross Dickins, Monash University, Australia (2000)
Monolineage origin of relapse following multilineage differentiation therapy of acute myeloid leukemia


18:00 - 19:30

Welcome Reception


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Friday, 23 August 2019


9:00 - 10:30

Session 3: Hematopoietic Stem Cell Biology

Sean Morrison, Children's Research Institute at University of Texas Southwestern Medical Center, USA (1005)

The identification of a peri-arteriolar niche for lymphoid progenitors and osteogenic progenitors in the bone marrow


Louise Purton, St. Vincent's Institute, Australia (1006)
Key roles of Hoxa1 in HSCs and myelodysplastic syndromes

Adam Wilkinson, Stanford University, USA (2001)
Long-Term Ex Vivo Expansion Of Functional Hematopoietic Stem Cells


Robert Signer, UC San Diego, USA (2002)
Ex vivo activation of Heat shock factor 1 (Hsf1) promotes sustained hematopoietic stem cell self-renewal


10:15 - 11:00

Exhibitor Hours


10:45 - 12:10

Session 4: Microenvironment I

Susie Nilsson, CSIRO, Australia (1007)
Metabolic restoration of the aged hematopoietic stem cell microenvironment

Simon Mendez-Ferrer, University of Cambridge and NHSBT, United Kingdom (1008)
Changing neighbours: bone marrow remodelling during aging and age-related myeloproliferative disorders


Marta Galan-Diez, Columbia University, Department of Physiology and Cellular Biophysics, USA(2003)
Acute myeloid leukemia cells seize serotonin signaling in osteoblasts to engraft and proliferate


Featured Poster Teasers: (3000), (3002), (3004), (3006), (3008)

11:45 - 14:30

Exhibitor Hours


 12:20 - 13:20

Junior PI Session: The Junior PI Survival Guide



13:25 - 13:55

Experimental Hematology Open Forum


14:15 - 15:45

Concurrent with Session 5B

Session 5A: Developmental Hematopoiesis

Zilong Wen, The Hong Kong University of Science & Technology, Hong Kong (1009)
An Ectoderm-Derived Myeloid-Like Cell Population Functions as Antigen Transporters for Langerhans Cells in Zebrafish Epidermis

Elizabeth Ng, Murdoch Childrens Research Institute, Australia (1010)
Characterizing HOXA-expressing endothelial and haematopoietic populations derived from human pluripotent stem cells


Samanta Mariani, University of Edinburgh, United Kingdom (2004)
Novel pro-inflammatory AGM-associated macrophages are involved in embryonic development of hematopoietic stem cells


Katrin Ottersbach, University of Edinburgh, United Kingdom (2005)
Gata3 promotes the endothelial-to-hematopoietic transition via regulation of the cell cycle


14:15 - 15:45

Concurrent with Session 5A

Session 5B: Cell Death

Gemma Kelly, The Walter and Eliza Hall Institute of Medical Research, Australia (1011)
The role of mutant p53 in tumor development and the response of malignant cells to anti-cancer therapeutics

Ben Kile, Monash University, Australia (1012)
Mitochondrial dynamics, damage, and inflammatory signalling

Gabriela Brumatti, Walter and Eliza Hall Institute of Medical Research, Australia (2007)
RIPping leukemias apart: The role of RIP kinase 1 in  Acute Myeloid Leukemia


1 additional short talk to be selected from abstracts

15:40 - 16:30

Exhibitor Hours


16:05 - 17:50

Concurrent with Session 6B


Session 6A: Epigenetic & Transcriptional Control

Anne Voss, Walter and Eliza Hall Institute of Medical Research, Australia (1013)
Chromatin proteins in haematopoietic stem cells and haematological malignancies

Grant Challen, Washington University, USA (1014)
The PRC2 Co-Factor JARID2 is a Key Regulator of Normal and Neoplastic Hematopoiesis

Catherine Carmichael, Monash University, Australia (2008)
Altered expression of Epithelial to Mesenchymal Transition modulators in Acute Myeloid Leukaemia - a model of LSD1 corruption


Carolina Guibentif, Cambridge Institute for Medical Research, United Kingdom (2009)
Disrupting the Master Regulators of Blood Emergence in the Mouse Embryo


Elizabeth Howell, University of Pennsylvania, USA  (2010)
Identifying necessary chromatin states and targets for hemogenic specification and reprogramming


16:05 - 17:50

Concurrent with Session 6A

Session 6B: Aging

Jason Butler, Center for Discovery and Innovation and Georgetown University, USA (1015)
Inhibition of Endothelial mTOR Drives Hematopoietic Stem Cell Aging

Liran Shlush, Weizmann Institute of Science, Israel (1016)
Early diagnosis and prevention of AML


Fumio Nakahara, University of Tokyo, Japan (2011)
Engineering a hematopoietic stem cell niche by revitalizing mesenchymal stem cell


Man Lee, Baker Heart & Diabetes Institute, Australia (2012)
Fibre prevents high salt diet-induced gut permeability, haematopoietic stem cell mobilisation and atherosclerosis

1 additional short talk to be selected from abstract submissions

18:00 - 19:45

Poster Viewing and Discussion I

20:00 - 21:30 

New Investigators Meet The Expert Mixer

                                                                               Back to Top

Saturday, 24 August 2019


8:00 -9:45

Session 7A: Hematopoietic Malignancies II

Andrew Roberts, The Walter and Eliza Hall Institute, Australia (1017)
Translational lessons in optimizing clinical use of BH3 mimetics to treat hematological malignancies

Christopher Park, New York University School of Medicine, USA (1018)
CD97 is a Critical Regulator of Acute Myeloid Leukemia Stem Cell Function

Cedric Tremblay, Australian Centre for Blood Diseases - Monash University, Australia (2014)
Dynamin-dependent endocytosis is required for multiple niche signals that are crucial for leukemia stem cell activity and chemoresistance


1 additional short talk to be selected from abstract submissions

Florence Borot, Columbia University Medical Center, USA (2016)
Gene edited stem cells combined with targeted immunotherapy: A novel approach to treat myeloid malignancies


8:00 - 9:45

Session 7B: Inflammation


Michael Milsom, German Cancer Research Center (DKFZ) & HI-STEM, Germany (1019)
Deconvolution of hematopoietic commitment decisions by genome-wide analysis of progressive DNA methylation changes 

Kate Schroder, Institute for Molecular Bioscience, The University of Queensland, Australia (1020)
New insights into inflammasome signalling and function during inflammation


Yoshikazu Hayashi, Kumamoto University, Japan (2017)
Microbial signal instructs early hematopoiesis upon intestinal tissue damage


Eirini Trompouki, Max Planck Institute of Immunobiolgy and Epigenetics, Germany (2018)
Transposable elements enhance hematopoietic regeneration via activation of innate immune signalling


1 short talk to be confirmed (2019)

9:30 - 10:15

Exhibitor Hours


10:05 - 11:35

Concurrent with Session 8B

Session 8A: Microenvironment II

Ingrid Winkler, Mater Research University of Queensland, Australia (1021)
Endothelial niche adhesive regulation of normal and malignant haematopoietic stem cells

Lei Ding, Columbia University, USA (1022)
Systematic genetic dissection of the hematopoietic stem cell niche in the fetal liver

Antonio Morales-Hernandez, St Jude Children's Research Hospital, USA (2020)
GPRASP family members regulate murine hematopoietic stem cell migration, homing and niche retention post-transplant via control of CXCR4 stability

Annas Al-sharea, Baker Heart and Diabetes Institute, Australia (2021)
Cholinergic influence of bone marrow vascular microenvironment influences hematopoietic stem cell mobilization


10:05 - 11:35

Concurrent with Session 8A

Session 8B: Progenitor Biology

Jinyong Wang,  Key Laboratory of Regenerative Biology, Chinese Academy of Sciences, China (1023)
Regeneration of T lymphopoiesis from pluripotent stem cells by defined factors

Tomohiko Tamura, Yokohama City University, Japan (1024)
Epigenetic control of myeloid cell development by the transcription factor IRF8

Christopher Sturgeon, Washington University in St. Louis, USA (2022)
Identification of a retinoic acid-dependent definitive hematopoietic progenitor from human pluripotent stem cells


Sara Tomei, Walter and Eliza Hall Institute of Medical Research, Australia (2023)
SIS-seq identifies the earliest lineage priming regulators of dendritic cell fate


11:30 - 13:45

Exhibitor Hours


11:45 - 12:45

New Investigators Career Session

12:50 - 13:20

STEMCELL Sponsored Technology Session

Amanda Fentiman, Product Manager - Hematology

Culturing, Editing & Assaying Normal and Malignant CD34+ Cells In Vitro

13:25 - 14:40


Session 9: ISEH & EHA Joint Session

Timm Schroeder, ETH Zurich, Basel, Switzerland (1025)
Long-term single-cell quantification: New tools for old questions

Tony Green, University of Cambridge, United Kingdom (1026)
JAK/STAT signalling, stem cell subversion and myeloid malignancies


Featured Poster Teasers: (3001), (3003), (3005), (3007), (3009), (3011)

14:35 - 15:10

Exhibitor Hours

15:00 - 16:55

Session 10: New Investigators Award Session


Marella de Bruijn, University of Oxford, United Kingdom (1027)

Development of hematopoietic stem cells


Student Award


Ruth Howe, Albert Einstein College of Medicine, USA (2024)
Deficiency of the novel tumor suppressor C15orf65 causes multiple myeloma and plasma cell malignancy

Olivia Cooney
, Baker Heart and Diabetes Institute, Australia (2025)
Rheumatoid Arthritis increases sympathetic nervous system driven hematopoietic stem cell mobilisation and atherogenesis

Dorit Schneider, Pediatric Hematology and Oncology - Hannover Medical School, Germany  (2026)
Ezh2 loss cooperates with loss of Bcor, Tet2 and Runx1 during leukemogenesis and reactivates a fetal gene signature


Postdoctoral Award


Alejo Rodriguez-Fraticelli, Boston Children's Hospital, Harvard Medical School, USA (2027)
Simultaneous lineage and transcriptional analysis of single HSCs identifies mechanisms of functional heterogeneity

Giorgia Scapin, Nationwide Children's Hospital, Ohio State University College of Medicine, USA (2028)
Pulsation in blood vessels stimulates mechanosensitive and epigenetic mechanisms to promote the birth of hematopoietic stem cells

Matthew Witkowski, New York University School of Medicine, USA (2029)
The relapsed B-cell acute lymphoblastic leukaemia immune microenvironment


17:00 - 18:45

Poster Viewing and Discussion II

19:30 - 22:00

Social Event

                                                    Back to Top

Sunday, 25 August 2019

9:00 - 10:30

Session 11: Metabolism

Toshio Suda, Kumamato University, Japan (1028)
Mitochondria Metabolism in Quiescent and Cycling Hematopoietic Stem Cells

Britta Will,
Albert Einstein College of Medicine, USA (1029)

Iron homeostasis-regulatory pathways in HSCs
Martina Stilinovic, Bern University Hospital, Switzerland (2030)
Ribonuclease Inhibitor (RNH1) regulates hematopoietic cell specific translation

Lev Kats, Peter MacCallum Cancer Centre, Australia (2031)
Delineating mechanisms of acquired resistance to IDH inhibitors in AML

11:00 - 12:45 

Session 12: Lineage Commitment

Andreas Trumpp,
German Cancer Research Center (DKFZ) and HI-STEM, Germany (1030)
Regulation of Hematopoietic and Immune Escape of AML Stem Cells

Shannon McKinney-Freeman,
St. Jude Children's Hospital and Research Center, USA (1031)
Ontogeny of the hematopoietic hierarchy

Nouraiz Ahmed, ETH Zurich, Switzerland (2032)
Dynamics quantification of transcription factor switches in HSPC lineage choice

Peter Kurre, University of Pennsylvania, USA (2033)
Replication Stress Mediated Checkpoint Activation During Physiologic HSC Expansion in the Fetal Liver leads to Hematopoietic Deficits in Fanconi Anemia


1 short talk reserved for Pre-Meeting Workshop Winner

13:00 - 14:00

New Investigators Technology Session

14:15 - 15:45

Session 13: Presidential Symposium

Connie Eaves, British Columbia Cancer Agency, Canada (1032)
Prospective Analysis of the Human Leukemogenic Process


Daniel Tenen, Cancer Science Institute of Singapore (CSI) and Harvard Medical School, Singapore and USA (1033)
Targeting the Oncofetal Protein SALL4 in Cancer

Mark Dawson, Peter MacCallum Cancer Centre, Australia (1034)
Epigenetic regulation in leukemias: From basic biology to new therapies

16:00 - 16:15

ISEH Annual Business Meeting

NI Award Session Award Presentation

16:15 - 17:00


Session 14: McCulloch & Till Award Lecture

David Traver, University of California San Diego, USA (1035)

Decoding the molecular cues that regulate HSC specification

Sponsored by Leukaemia Foundation


17:00 - 17:30 

Closing Remarks

more Calendar

ISEH Summer Webinar: Changing views of lineage commitment

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