
*Last updated 24 August 2018. Subject to change.


7:00 - 11:00 |
Registration Open |
Centennial Pre-Function, Level 1 |
8:30 - 14:00
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New Investigator Pre-meeting Workshop
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Legacy, Level 2 |
8:00 - 13:00
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ISEH Board of Directors Meeting
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Transformation, Level 2 |
13:00 - 18:15 |
Registration Open
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Centennial Pre-Function, Level 1
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14:15 - 14:45
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First-Time Attendee Event |
Transformation, Level 2 |
15:00 - 15:15
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Welcome and Opening Remarks
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Centennial Ballroom, Level 1 |
15:15 - 16:00
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Session 1: Donald Metcalf Lecture Award
Chair: Hanna Mikkola, University of California Los Angeles, USA
Speaker: Nancy A. Speck, University of Pennsylvania, USA (1001)
Hematopoietic cell formation in the major arteries of mouse embryo
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Centennial Ballroom, Level 1 |
16:00 - 16:15
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Break - coffee & tea served
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Centennial Pre-Function, Level 1 |
16:15 - 18:00
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Session 2: Gleevec- From Basic Science to Wonder-Drug
Chair: Gay Crooks, University of California Los Angeles, USA
Confirmed Speaker 1: Owen Witte, University of California, LA, USA (1002)
The Abl Oncogene and Kinase Targeted Therapies
Confirmed Speaker 2: Nick Lydon, Blueprint Medicines, USA (1003)
The development of Imatinib and its impact on precision medicine
Confirmed Speaker 3: Catriona Jamieson, UC San Diego Moores Cancer Center, USA (1004)
Chronic Myeloid Leukemia: The Impact of Clonal Evolution
Featured Posters (3121), (3063), (3113), (3214), (3086), (3231), (3223), (3010), (3123), (3165)
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Centennial Ballroom, Level 1 |
18:00 - 19:30
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Welcome Reception
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Centennial Terrace, Level 3 |
8:00 - 9:00 |
New Investigators Committee Meeting |
Odyssey, Level 1 |
8:00 - 9:00 |
Odd # Poster Set Up
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Centennial Terrace, Level 3 |
8:30 - 18:00 |
Registration Open
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Centennial Pre-Function, Level 1 |
9:00 - 10:30
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Session 3: Hematopoietic Stem Cell (HSC) Biology I
Confirmed Speaker 1: Margaret Goodell, Baylor College, USA (1005)
DNA Methyltransferase 3A in Normal and Malignant Hematopoiesis
Confirmed Speaker 2: Dominique Bonnet, Crick Institute, UK (1006)
Human Normal Haematopoetic Stem Cell Heterogeneity
Short Talk 1: Pia Sommerkamp, Division of Stem Cells and Cancer, DKFZ, Germany (2001)
Hematopoietic Stem Cells Are Regulated by Alternative Polyadenylation
Short Talk 2: Derek Chan, McMaster University Institute, Canada (2002)
The mitotic spindle orientation factor for Lfc/Arhgef2 is essential for hematopoietic stem cell function
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Centennial Ballroom, Level 1 |
10:15 - 11:00 |
Exhibitor Hours
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Centennial Pre-Function, Level 1 |
10:30 - 10:50
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Break - coffee & tea served
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Centennial Pre-Function, Level 1 |
10:50 - 12:05
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Session 4: Developmental Hematopoiesis I
Chair: Anna Beaudin, University of California-Merced, USA
Confirmed Speaker 1: David Traver, University of California, San Diego, USA (1007)
Wnt9a Interacts Specifically with Frizzled9b to Regulate the Emergence of Hematopoietic Stem Cells
Confirmed Speaker 2: Kyunghee Choi, Washington University, USA (1008)
ETV2/ER71 Threshold Expression and Hemangiogenic Fate Commitment
Short Talk: Emanuele Azzoni, University of Oxford, United Kingdom (2003)
The mouse hematopoietic stem cell lineage fails to develop beyond the pro-HSC stage in the absence of blood flow
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Centennial Ballroom, Level 1 |
12:00 - 14:30
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Exhibitor Hours |
Centennial Pre-Function, Level 1 |
12:05 - 13:05
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Junior PI "Meet the Editors" Lunch (with short talks)
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Legacy, Level 2 |
12:05 - 13:05
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Informal Networking and Lunch
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Level 2 |
13:05 - 13:35
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Sponsored Technology Sessions

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Optimist, Level 2 |
14:15 - 15:50
Concurrent with Session 5B
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Session 5A: Hematopoietic Malignancies I
Chair: Teresa Bowman, Albert Einstein College of Medicine, USA
Confirmed Speaker 1: John Crispino, Northwestern University, Chicago, USA (1009)
A CHAF1B-Dependent Molecular Switch in Hematopoiesis and Leukemia
Confirmed Speaker 2: Tao Cheng, Chinese Academy of Medical Sciences, China (1010)
What Happens to the Normal Counterparts of Leukemia Cells in the Body?
Short Talk 1: Jan Cools, VIB Center for Cancer Biology, KU Leuven Center for Human Genetics, Belgium (2004)
Cooperative enhancer activation by TLX1 and STAT5 drives leukemia development in NUP214-ABL1/TLX1-positive T-cell acute lymphoblastic leukemia
Short Talk 2: Yu-lin Su, Beckman Research Institute, City of Hope, USA (2005)
Targeted delivery of miR0146a mimic oligonucleotides as a potential therapeutic approach to modulate NF-kB signaling in myeloid leukemia and myeloproliferative diseases
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Centennial A/B, Level 1
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14:15 - 15:50
Concurrent with Session 5A
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Session 5B: Microenvironment and Extrinsic Control of HSCs
Chair: Paul Frenette, Albert Einstein College of Medicine, USA
Confirmed Speaker 1: Linheng Li, Stowers Institute, USA (1011)
The Regulation of Reserve Hematopoietic Stem Cells by N-Cadherin Expressing Mesenchymal Stem Cells in Bone Marrow Niche
Confirmed Speaker 2: Michael Rieger, Goethe University Frankfurt, Germany (1012)
Cytokine-induced regulatory circuits in the control of early hematopoietic stem cell fate decisions
Short Talk 1: Stephanie Smith-Berdan, UCSC, USA (2006)
Viagra Enables Efficient, Single-Day Hematopoietic Stem Cell Mobilization
Short Talk 2: Katherine King, Baylor College of Medicine, USA (2007)
Interferon gamma increases hematopoietic stem cell homing to an activated bone marrow niche
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Centennial C/D, Level 1 |
15:45 - 16:15 |
Exhibitor Hours |
Centennial Pre-Function, Level 1 |
15:50 - 16:15
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Break - coffee & tea served
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Centennial Pre-Function, Level 1 |
16:15 - 18:00
Concurrent with Session 6B
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Session 6A: Hematopoiesis During Aging and Stress
Chair: Gerald de Haan, European Research Institute for the Biology of Ageing, Netherlands
Confirmed Speaker 1: Hartmut Geiger, Cincinnati Children's Hospital, USA (1013)
Mechanisms of Aging of Hematopoietic Stem Cells
Confirmed Speaker 2: Isabel Beerman, NIH, USA (1014) Stress: Is a little bit beneficial?
Short Talk 1: Mehmet Sacma, Institute for Molecular Medicine, Stem Cells and Aging, Ulm University, Germany (2008)
Hematopoietic stem cells in perisinusoidal niches are protected from aging, Mehmet Sacma
Short Talk 2: Evgenia Verovskaya, Columbia University Medical Center, USA (2009)
Inflammatory changes in the bone marrow microenvironment drive both niche and blood system remodeling during aging
Short Talk 3: Tiago Cunha Luis, University of Oxford, United Kingdom (2010)
Perivascular niche cells sense thrombocytopenia and activate platelet-biased HSCs in an IL-1 dependent manner
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Centennial A/B, Level 1 |
16:15 - 18:00
Concurrent with Session 6A
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Session 6B: Developmental Hematopoiesis II
Chair: James Palis, University of Rochester Medical Center, USA
Confirmed Speaker 1: Feng Liu, Chinese Academy of Sciences, China (1015)
Epigenetic Control of Hematopoietic Stem Cell Development
Confirmed Speaker 2: Igor Slukvin, Universiy of Wisconsin, USA (1016)
Arterial Programming of Hemogenic Endothelium
Short Talk 1: Clair Kelley, St Jude Children's Research Hospital, USA (2011)
Contribution of Sclerotome to the Hematopoietic Stem Cell Niche and Vascular Smooth Muscle
Short Talk 2: John Pimanda, UNSW Sydney, Australia (2012)
Mesoderm-derived PDGFRA+ cells regulate emergence of hematopoietic stem cells in the dorsal aorta
Short Talk 3: Atesh Worthington, University of California Santa Cruz, USA (2013)
Flk2 & Il7ra: Drivers of Innate Lymphoid Cell Development
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Centennial C/D, Level 1 |
18:00 - 19:50
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Poster Viewing and Discussion I (Odd Abstracts)
Sponsored by:
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Centennial Terrace, Level 3 |
19:50 - 20:30 |
Odd # Poster Take Down |
Centennial Terrace, Level 3 |
20:00 - 21:30
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New Investigators Meet The Expert Mixer
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Centennial Pre-function & Patio, Level 1 |
7:45 - 18:30
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Registration Open |
Centennial Pre-Function, Level 1 |
8:00 - 9:00 |
Even # Poster Set Up |
Centennial Terrace, Level 3 |
8:15 - 10:00 |
Session 7A: Transcriptional and Epigenetic Regulation I
Chair: Patricia Ernst, University of Colorado, Denver/Anschutz Medical Campus, USA
Confirmed Speaker 1: Ellen Rothenberg, California Institute of Technology, USA (1017)
Regulation of genomic activity in T-lymphocyte development by dynamic transcription factor ensembles
Confirmed Speaker 2: Catherine Porcher, University of Oxford, UK (1018)
Transcriptional and Epigenetic Control of Blood Lineage Specification
Short Talk 1: Alan Cantor, Boston Children's Hospital and Dana-Farber Cancer Institute/Harvard Medical School, USA (2014)
GATA Transcription Factor Switching Shapes 3d Chromatin Architecture During Erythroid Maturation
Short Talk 2: Alexandra Soukup, University of Wisconsin – Madison, USA (2015)
GATA-2 dependent Hematopoietic Disease Mechanism
Short Talk 3: Vincenzo Calvanese, University of California Los Angeles, USA (2016)
Human Hematopoietic Stem Cell Self-Renewal and Engraftment Are Enhanced by the Transcriptional Regulator MLLT3
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Centennial A/B, Level 1 |
8:15 - 10:00 |
Session 7B: HSC Biology II
Chair: Toshio Kitamura, The University of Tokyo, Japan
Confirmed Speaker 1: Nadia Carlesso, City of Hope, USA (1019)
Defective Notch Activation in Mesenchymal Cells Accelerates the Aging of the Bone Marrow Niche and Favor Hematopoietic Malignancies
Confirmed Speaker 2: Elisa Laurenti, Cambridge, UK (1020)
Functional and Molecular Heterogeneity Within the Human Haematopoietic Stem Cell Compartment at Homeostasis and Under Stress
Short Talk 1: Raphael Lis, Weil Cornell Medicine Institute, USA (2017)
Engineering converted autologous hematopoietic stem cells from vascular endothelial cells for treatment of hemoglobinopathies
Short Talk 2: Eva Fast, Harvard University, USA (2018)
A Short Pulse of Prostaglandin E2 (PGE2) affects long term clonal dynamics during hematopoietic stem cell transplantation
Short Talk 3: Qiaozhi Wei, Albert Einstein College of Medicine, USA (2019)
Maea is a critical regulator of hematopoietic stem cell and erythroblastic island macrophage maintenance
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Centennial C/D, Level 1 |
9:50 - 10:30 |
Exhibitor Hours |
Centennial Pre-Function, Level 1 |
10:00 - 10:20
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Break - coffee & tea served
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Centennial Pre-Function, Level 1 |
10:20 - 11:50
Concurrent with Session 8B
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Session 8A: Highlighting Experimental Hematology
Chair: Connie Eaves, Terry Fox Laboratory, Canada
Confirmed Speaker 1: Gay Crooks, University of California, LA, USA (1021)
Building Bridges Between Stem Cells and T cells
Confirmed Speaker 2: Jean Pierre Levesque, Translational Research Institute Australia, Australia (1022)
Macrophages Are Essential Regulators of Hematopoietic and Bone Tissues
Short Talk 1: Raymond Liang, Icahn School of Medicine at Mt. Sinai Institute, USA (2020)
Mitochondrial Regulation is Essential for Erythroid Nuclear Removal
Short Talk 2: Dirk Loeffler, Cell Systems Dynamics, Department of Biosystems Science and Engineering (D-BSSE), ETH Zurich, Switzerland (2021)
Asymmetic cell division controls hematopoietic stem cell metabolic activation and differentiation
Session Sponsor:

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Centennial A/B, Level 1 |
10:20 - 11:50
Concurrent with Session 8A
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Session 8B: Advancing Hematopoiesis Research Through Single Cell Technologies
Chair: H Leighton Grimes, Cincinnati Children's Hospital Medical Center, USA
Confirmed Speaker 1: Kara Lynn Davis, Stanford University, USA (1023)
Single-Cell Developmental Classification of B-Cell Precursor Acute Lymphoblastic Leukemia at Diagnosis Reveals Predictors of Relapse
Confirmed Speaker 2: Adam Mead, University of Oxford, UK (1024)
Short Talk 1: Peter van Galen, Massachusetts General Hospital and Broad Institute of Harvard and MIT, USA (2022)
Single-cell analysis of AML reveals determinants of disease progression and immune evasion
Short Talk 2: Simon Haas, DKFZ / HI-STEM, Germany (2023)
Multi-layered Single-cell Transcriptional Profiling of All Bone and Bone Marrow Populations Provides a Systems View of the Mesenchymal and Hematopoietic Stem Cell Niche
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Centennial C/D, Level 1 |
11:45 - 14:00 |
Exhibitor Hours |
Centennial Pre-Function, Level 1 |
11:55 - 12:55
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Informal Networking and Lunch
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Level 2 |
11:55 - 12:55
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New Investigators Career Session
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Legacy, Level 2 |
12:00 - 13:00
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Scientific Program Committee Meeting |
Odyssey, Level 1 |
13:00 - 13:45
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Sponsored Technology Session
Miguel Tam, San Diego, California, USA

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Optimist, Level 2 |
13:50 - 15:00
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Session 9: Transcriptional and Epigenetic Regulation II
Chair: Claus Nerlov, University of Oxford, United Kingdom
Confirmed Speaker 1: Stephen Smale, University of California, LA, USA (1025)
A Quantitative Perspective of Transcription in Pluripotent and Differentiated Cells
Short Talk 1: Jian Xu, Children's Research Institute, UT Southwestern Medical Center, USA (2024)
Loss of EZH2 Activates BCAA Metabolism to Drive Myeloid Transformation
Short Talk 2: Constanze Bonifer, University of Birmingham, United Kingdom (2025)
Subtype-specific regulatory network rewiring in acute myeloid leukemia
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Centennial Ballroom, Level 1 |
15:00 - 15:20
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Break - coffee & tea served
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Centennial Pre-Function, Level 1 |
15:00 - 15:30 |
Exhibitor Hours |
Centennial Pre-Function, Level 1 |
15:20 - 17:15
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Session 10: New Investigator Award Session
Chair: Isabel Beerman, NIH, USA
Confirmed Speaker 1: Keisuke Ito, Albert Einstein College of Medicine, USA (1026)
Insights into the Metabolic Control of Hematopoietic Stem Cell Fate
Student Award
Short Talk 1: Jiahao Chen, Albert Einstein College of Medicine, USA (2026)
MDS Progression to AML at the Stem Cell Level
Short Talk 2: Gabriela Krivdova, University of Toronto, Canada (2027)
miR-130a regulates hematopoietic stem cell self-renewal by repressing several chromatin modifiers and its overexpression is associated with acute myeloid leukemia
Short Talk 3: Rachel Hynes-Smith, University of Nebraska Medical Center, USA (2028)
Loss of FBXO9 Accelerates the Onset of Acute Myeloid Leukemia
Postdoctoral Award
Short Talk 1: Philip Boulais, Albert Einstein College of Medicine, USA (2029)
Stromal-dependent hematopoietic progenitors permeate the CD45CD31Ter119 bone marrow cell fraction
Short Talk 2: Konstantinos Kokkaliaris, ETH Zurich, Switzerland (2030)
Quantitative bone-marrow imaging reveals niche signatures of distinct types of adult and juvenile hematopoietic stem cells
Short Talk 3: Larry Luchsinger, Columbia University Medical Center, USA (2031)
Maintenance of Hematopoietic Stem Cells in a Low Calcium Environment
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Centennial Ballroom, Level 1 |
17:20- 19:10
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Poster Viewing and Discussion II (Even Abstracts)
Sponsored by:

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Centennial Terrace, Level 3 |
19:10 - 20:00 |
Even # Poster Take Down |
Centennial Terrace, Level 3 |
19:30- 22:00
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Social Event
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W Hotel Pool Deck, 930 Hilgard Avenue |
8:00 - 9:00
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Publications Committee Meeting |
Transformation, Level 2 |
8:30 - 16:00
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Registration Open |
Centennial Pre-Function, Level 1 |
9:00 - 10:30
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Session 11: Hematopoietic Malignancies II
Chair: Grant Challen, Washington University School of Medicine, USA
Confirmed Speaker 1: Ravi Majeti, Stanford, USA (1027)
Stem Cells in Human AML
Confirmed Speaker 2: Markus Müschen, Duarte, City of Hope, USA (1028)
B-Cell Identity as a Metabolic Barrier Against Malignant Transformation
Short Talk 1: Pablo Menendez, Leukemia Research Institute Josep Carreras, Spain (2032)
Chromosome Segregation defects as early underlying pathogenic mechanism in hyperdiploid childhood B-cell acute lymphoblastic leukemia
Short talk 2: Therese Vu, QIMR Berghofer Medical Research Institute, Australia (2033)
Cdx2 expression in hematopoietic stem cells represents a novel model of de novo leukemia
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Centennial Ballroom, Level 1 |
10:30 - 10:55
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Break - coffee & tea served
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Centennial Pre-Function, Level 1 |
11:00 - 12:45
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Session 12: Lineage Differentiation
Chair: Claudia Waskow, Leibniz Institute on Aging, Germany
Confirmed Speaker 1: Sten Eirik Jacobsen, Karolinska Institute, Sweden (1029)
Unraveling the Lineage Potentials, Fates and Restriction Pathways of Hematopoietic Stem and Progenitor Cells
Confirmed Speaker 2: Marjorie Brand, Ottawa Hospital Research Institute, Canada (1030)
Understanding Cell Fate Decisions in Erythropoiesis Using Quantitative Proteomics and Single-cell Mass Cytometry
Short Talk 1: Amelie Montel-Hagen, University of California, Los Angeles, USA (2034)
Directed differentiation of conventional T cells from Human Pluripotent Stem Cells in an artificial organoid system
Short Talk 2: Smrithi Rajendiran, University of California, Santa Cruz, USA (2035)
In vivo lineage potential of hematopoietic stem and progenitor cells using a novel quantification method suggests an erythroid-favored differentiation model
Short Talk 3: Reserved for Pre-Meeting Workshop Winner
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Centennial Ballroom, Level 1 |
12:45 - 14:15 |
Informal Networking and Lunch |
Level 2 |
13:00 - 14:00
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New Investigators Technology Session & Lunch
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Legacy, Level 2 |
13:00 - 14:00
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Editorial Board Meeting |
Optimist, Level 2 |
14:15 - 15:45
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Session 13: Presidential Symposium
Chair: Hanna Mikkola, University of California Los Angeles, USA
Confirmed Speaker 1: Stuart Orkin, Harvard Medical School (1031)
Reactivation of fetal hemoglobin for therapy: From GWAS to the clinic
Confirmed Speaker 2: Deepak Srivastava, Gladstone Institutes and University of California, San Francisco (1032)
Cardiac Development: Basis for Disease and Regeneration
Confirmed Speaker 3: Gordon Keller, University Health Network, Canada (1033)
Translating human development to new therapies with pluripotent stem cells
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Centennial Ballroom, Level 1 |
15:45 - 16:00
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Break - coffee & tea served
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Centennial Pre-Function, Level 1 |
16:00 - 16:15
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ISEH Annual Business Meeting
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Centennial Ballroom, Level 1 |
16:15 - 17:00
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Session 14: McCulloch & Till Lecture Award
Chair: Bertie Gottgens
Confirmed Speaker: Atsushi Iwama, Chiba University, Japan (1034)
PRC1.1, a variant polycomb repressive complex 1 in normal and malignant hematopoiesis
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Centennial Ballroom, Level 1 |
17:00 - 17:30
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Closing Remarks
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Centennial Ballroom, Level 1 |
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