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2012 Schedule of Events
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View the ISEH 2012 Annual Meeting Abstract Book

View the Late Breaking Abstracts by clicking here.

"This international meeting is the ideal mix of intimate size and groundbreaking science. It has a casual, friendly atmosphere that’s just right for exchanging ideas between experienced scientists and young investigators alike.”

- David Scadden, MD, Gerald & Darlene Jordan Professor of Medicine, Harvard University, and 2011 Annual Scientific Meeting Chair.


Schedule of Events*



Thursday 23 August 2012


Opening Remarks

1530 – 1630

Session 1: Donald Metcalf Lecture

Transcriptional Control of Blood Cell Lineage and Developmental Stage
Stuart H. Orkin, MD

Dana-Farber Cancer Institute, Cambridge, MA, USA


1630 – 1645


1645 - 1745

Session 2: Sanquin Mini-Symposium on Embryonic Stem Cells

IPSC: A Source of Universal Red Blood Cells for Transfusion Medicine
Luc Douay, MD, PhD

Hôpitaux Universitaires Paris, Armand-Trousseau, Paris, France

Specification of Angiohematopoietic Precursors from Human Pluripotent Stem Cells

Igor Slukvin, MD, PhD

University of Wisconsin, Madison, USA



1800 -1830

Session 3: New Investigator Lecture

Genetic and Epigenetic Mechanisms Underlie Hematopoietic Stem Cell Aging
Derrick Rossi, PhD

Harvard Stem Cell Institute, Cambridge, MA, USA


1845 – 2045

Welcome Reception



Friday 24 August 2012

Room 1

Room 2

900 - 1045

Session 4: Leukemia & Lymphoma

Challenges and Opportunities for Curing inv(16)-associated Acute Myeloid Leukemia: What We Have Learned from the Animal Models
Christopher Klug, PhD
University of Alabama at Birmingham, Alabama, USA

Approaches to Eradicate CML Stem Cells
Tessa Holyoke, MBChB, MRCP, MRCPath, PhD, FRCP, FRCPath, FRSE
University of Glasgow, Scotland, UK



Session 5: Hematopoietic Stem Cell Biology

Self-Renewal Potential of Human Haematopoietic Stem Cells in Development
Alexander Medvinsky, PhD
Institute for Stem Cell Research,
University of Edinburgh, Edinburgh, UK



1045 – 1115


1115 – 1215

Session 6: Leukemia & Lymphoma (cont'd)

Mechanisms of Immune Escape in Lymphoid Cancers
Randy Gascoyne, MD, FRCPC

BC Cancer Agency, Vancouver, Canada

Epigenetic Basis of Hematologic Malignancies
Ari Melnick, MD
Weill Cornell University, New York, NY, USA

Session 7: Hematopoietic Stem Cell Biology (cont'd)

Functional Heterogeneity of Hemogenic Endothelium
Nancy Speck, PhD
Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA, USA

Abstract Presentations


1215 - 1345

Lunch/New Investigator Meet the Professor Lunch

1345 – 1515

Session 8: Developmental Biology

Role of the Paraxial and Lateral Mesoderm in the Control of Aorta-associated Haematopoiesis and the Subsequent Formation of the Definitive Haematopoietic System
Thierry Jaffredo, PhD

Pierre and Marie Curry University, Paris, France

Abstract Presentations


Session 9: Transcription/Translation

Erythropoiesis and Globin Switching in Compound Klf1::Bcl11a Mutant Mice
Sjaak Philipsen, PhD

ErasmusMC, Rotterdam, Netherlands


Control of Erythropoiesis by Selective mRNA Translation
Marieke van Lindern, PhD

Sanquin Research and Landsteiner Laboratory, Amsterdam, Netherlands

Abstract Presentations


1545 - 1730

Session 10: Developmental Biology (cont'd)

Programming Blood Stem Cells in Xenopus and Zebrafish Embryos
Roger Patient, PhD
Abstract PresentationsUniversity of Oxford, Oxford, UK


Session 11: Lymphoid Cells & Microenvironment

Lymph Node Stromal Cells
Reina Mebius, PhD

VU University Medical Center, Amsterdam, Netherlands


Notch Signaling in Normal and Malignant T-Cells
Freddy Radtke, PhD

École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

Abstract Presentations


1730 – 1845

Poster Viewing & Discussion
Odd # posters available for viewing

1900 – 2030

New Investigator Networking Rendezvous



Saturday 25 August 2012

Room 1

Room 2

900 - 1030

Session 12: Novel Tools in Hematology

Interrogating the Architecture of Cancer Genomes
Peter Campbell, PhD

Wellcome Trust Sanger Institute, Cambridge, UK

The Transcription Factor Ldb1 Plays a Primary Role in Early Development by Controlling Essential Hematopoietic Genes/Pathways
Frank Grosveld, PhD

ErasmusMC, Rotterdam, Netherlands

Abstract Presentations


Session 13: Sanquin Mini-Symposium on ES Cells (cont'd)

Directed Differentiation of Human Pluripotent Stem Cells to a Definitive Hematopoietic Fate
Gordon Keller, PhD

McEwen Centre for Regenerative Medicine, Toronto, Canada

Generation of Tissues Derived from the Anterior Foregut from Human Pluripotent Cells
Hans Snoeck, MD, PhD

Mount Sinai School of Medicine, New York, NY, USA

Abstract Presentations


1030 – 1100


1100 – 1230

Session 14: Genetic Regulation of Stem Cells

Targeting Leukemia Cells within Their In Vivo Microenvironment
Benjamin Ebert, MD

Harvard Medical School, Cambridge, MA, USA

Abstract Presentations


Session 15: Progenitors and Stem Cells
Abstract Presentations

1230 – 1345

Lunch/New Investigator Career Panel 1

1345 - 1545

Session 16: New Investigator Award Session
PhD Abstract Presentations
Postdoc Abstract Presentations

1545 - 1615


1615 – 1800

Session 17: Presidential Symposium

Pluripotency, etc.
Ihor Lemischka, PhD

Black Family Stem Cell Institute, Mount Sinai School of Medicine, New York, NY, USA

Controlling Gene Expression Fluctuations during Development
Alexander van Oudenaarden, PhD

Massachusetts Institute of Technology, Cambridge, MA, USA

Strategies of Adult Stem Cell Self-renewal
Ben Simons, PhD

University of Cambridge, Cambridge, UK

Presentation of the New Investigator Awards


1800 - 1915

Posters Viewing & Discussion
Even # posters available for viewing

19:45 – 2400

Social Event


Sunday 26 August 2012

Room 1

Room 2

900 – 1030

Session 18: Epigenetics

Role of the Polycomb Group Proteins in the Maintenance of Hematopoietic Stem Cells and Restriction of Tumor Development
Atsushi Iwama, MD, PhD

Chiba University, Chiba, Japan

RUNX1 Orchestrates the Establishment of Alternate Transcription Factor Binding Patterns during the Endothelial – Hematopoietic Transition
Constanze Bonifer, PhD

University of Birmingham, Birmingham, UK

Abstract Presentations


Session 19: Transplantation & Gene Therapy

Hematopoeitic Stem Cell Transplantation Versus Gene Therapy for Inherited Disorders of the Hematopoeitic System
Marina Cavazzano-Calvo, MD, PhD

Institut National de la Santé et de la Recherche Médicale, Paris, France

Wnt Signaling Strength Regulates Normal Hematopoiesis and its Deregulation is Involved in Leukemia Development

Frank Staal, PhD

Leiden University Medical Center, Leiden, Netherlands

Abstract Presentations



1030 – 1100


1100 – 1200

Session 20: Microenvironment

Hematopoietic Stem Cell Microenvironments
Paul Frenette, MD

Albert Einstein College of Medicine, New York, NY, USA

Abstract Presentations


Session 21: Transplantation & Gene Therapy (cont'd)

Development of Mechanism-Based Therapies for Diamond-Blackfan Anemia
Stefan Karlsson, MD, PhD

Lund Stem Cell Center, Lund, Sweden

Abstract Presentations


1200 - 1330


Annual General Meeting/New Investigator Career Panel 2

1330 - 1500

Session 22: Microenvironment

Hypoxia and E-Selectin are Opposite Regulators of Hematopoietic Stem Cell Quiescence in the Niche
Jean-Pierre Leveque, PhD

Mater Medical Research Institute, Melbourne, Australia

Abstract Presentations


1500 – 1530


1530 – 1630

Session 23: McCulloch & Till Lecture

Tracking Hematopoiesis at the Single Cell Level: New Tools for Old Questions
Timm Schroeder, PhD

Helmholtz Center, Munich, Germany



Closing Remarks

*Schedule subject to change. Check back often.

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