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ISEH Webinar: The Role of Inflammatory Signals in Embryonic HSC Development and Adult HSC Function
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In this webinar, we will hear from experts on the role of inflammatory signals on HSC function. Dr. Marcus Manz (University Hospital Zurich) will speak about the effect of inflammation on adult HSC function. Dr. Trista North (Harvard Stem Cell Institute) will talk about the role of pro-inflammatory signals on HSC emergence in the embryo. Dr. Katherine King (Baylor College of Medicine), an expert on the effect of infection on adult HSC function, will serve as the moderator.

When: 5 April 2016
Where: United States
Contact: Heather Nichols

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The Role of Inflammatory Signals in Embryonic HSC Development and Adult HSC Function

Presenter Information

Marcus Manz - University Hospital Zurich

Trista North - Harvard Stem Cell Institute

Moderated by: Katherine King - Baylor College of Medicine



Presenters, left to right, Marcus Manz, Trista North, Katherine King, moderator

Pro-inflammatory cytokines are produced by cells of the immune system in response to microbial infection. Inflammation can also be driven by pathological situations not driven by microbial invasion such as atherosclerosis, type III hypersensitivity, trauma and ischemia. While inflammatory signals have classically been thought to be produced and effected by mature cells of the hematopoietic system, recent studies suggest that inflammatory signals have crucial roles that act directly on the most primitive hematopoietic stem cells (HSCs), both during embryonic development and at steady state in the adult.

HSCs underlie the production of blood and immune cells for the lifetime of an organism. In vertebrate embryonic development, HSCs arise from the transdifferentiation of hemogenic endothelium and recent studies demonstrate that pro-inflammatory signaling, in the absence of infection, is utilized by the developing embryo to generate the precursors of the adult hematopoietic system. In the adult, HSCs have been thought of generally as dormant cells that are only called upon to divide under extreme conditions. However, recent studies suggest that hematopoietic stem cells respond directly and immediately to infections and inflammatory signals. In this webinar, we will hear how inflammatory signals influence definitive HSC emergence in the developing embryo, and how adult HSCs respond to exposure to pro-inflammatory cytokines. These molecular pathways may be a major contributor to the hematopoietic abnormalities that occur in aging individuals, such as increased incidence of bone marrow failure syndromes and cancer. 

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