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Inside This Issue Aug/Sept

Posted By Connections Editor, Friday, September 8, 2017


CBP/Catenin antagonists: Targeting LSCs’ Achilles heel
Yong-Mi Kim, Eun-Ji Gang, Michael Kahn

Reprogramming acute myeloid leukemia into sensitivity for retinoic-acid-driven differentiation
Noortje van Gils, Han J.M.P. Verhagen, Linda Smit

Reciprocal regulation between hepcidin and erythropoiesis and its therapeutic application in erythroid disorders
Caiyi Wang, Zheng Fang, Zesen Zhu, Jing Liu, Huiyong Chen

With me or against me: Tumor suppressor and drug resistance activities of SAMHD1
Nikolas Herold, Sean G. Rudd, Kumar Sanjiv, Juliane Kutzner, Ida Hed Myrberg, Cynthia B.J. Paulin, Thale Kristin Olsen, Thomas Helleday, Jan-Inge Henter, Torsten Schaller

FLT3 ligand regulates thymic precursor cells and hematopoietic stem cells through interactions with CXCR4 and the marrow niche
Kirsten M. Williams, Amber R. Moore, Philip J. Lucas, Juin Wang, Catherine V. Bare, Ronald E. Gress

HIF-1α-stabilizing agent FG-4497 rescues human CD34+ cell mobilization in response to G-CSF in immunodeficient mice
Bianca Nowlan, Kathryn Futrega, Marion E. Brunck, Gail Walkinshaw, Lee E. Flippin, Michael R. Doran, Jean-Pierre Levesque

D816V mutation in the KIT gene activation loop has greater cell-proliferative and anti-apoptotic ability than N822K mutation in core-binding factor acute myeloid leukemia
Ikuko Omori, Hiroki Yamaguchi, Koichi Miyake, Noriko Miyake, Tomoaki Kitano, Koiti Inokuchi

Development of an assay for cellular efflux of pharmaceutically active agents and its relevance to understanding drug interactions
Benigno C. Valdez, Moustapha Hassan, Borje S. Andersson



B-cell identity as a metabolic barrier against malignant transformation 

Lai N. Chan, Markus Müschen

TAL1 as a master oncogenic transcription factor in T-cell acute lymphoblastic leukemia
Takaomi Sanda, Wei Zhong Leong

Novel tumor-suppressor function of KLF4 in pediatric T-cell acute lymphoblastic leukemia
Ye Shen, Taylor J. Chen, H. Daniel Lacorazza

Lifelong dietary intervention does not affect hematopoietic stem cell function
Seka Lazare, Albertina Ausema, Aaffien C. Reijne, Gertjan van Dijk, Ronald van Os, Gerald de Haan

A novel dual inhibitor of microtubule and Bruton's tyrosine kinase inhibits survival of multiple myeloma and osteoclastogenesis
Manoj K. Pandey, Krishne Gowda, Shen-shu Sung, Thomas Abraham, Tulin Budak-Alpdogan, Giampolo Talamo, Sinisa Dovat, Shantu Amin

PRKCH regulates hematopoietic stem cell function and predicts poor prognosis in acute myeloid leukemia
Shaina N. Porter, Jeffrey A. Magee

Whole-genome analysis reveals unexpected dynamics of mutant subclone development in a patient with JAK2-V617F-positive chronic myeloid leukemia
Ivan Sloma, Maria Teresa Mitjavila-Garcia, Olivier Feraud, Frank Griscelli, Noufissa Oudrhiri, Sanaa El Marsafy, Emilie Gobbo, Dominique Divers, Alexis Proust, David M. Smadja, Christophe Desterke, Annaick Carles, Yusanna Ma, Martin Hirst, Marco A. Marra, Connie J. Eaves, Annelise Bennaceur-Griscelli, Ali G. Turhan

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