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2013 webinar series concludes with lecture on xenograft models

Posted By Connections Editor, Tuesday, January 7, 2014

On December 16th 2013, ISEH had the privilege to host the webinar of Dr. Gwenn Danet-Desnoyers entitled "Xenograft models of human hematopoiesis and leukemia". Dr. Danet-Desnoyers is the Director of the Stem Cell and Xenograft Core and an adjunct Associate Professor at theUniversity of PennsylvaniaSchool of Medicine. He has help organized one of the most comprehensive resource lab in the US with a large tissue bank and a variety of xenograft models to accelerate the treatment of leukemic patients.

During the first part of the talk, Dr. Danet-Desnoyers highlighted the requirements for the xenogenic reconstitution of the human hemato-lymphoid system and explained the importance of human cytokines to provide signals that support human cell survival, development and function in mice. He presented studies from his lab that: 1) compared the ability of CD34+ cells from cord blood, fetal liver and BLT to reconstitution in NSG mice; 2) compared human immune reconstitution in NSG, NRG and NSG-SGM3 mice, and 3) investigated the effect of exogenous support with IL-15/IL-15Ra complex on NK development. Dr. Danet-Desnoyers concluded this part of the talk with a discussion of the limitations of the established models and possible solutions.

The second part of the webinar was devoted to patient-derived xenograft models for AML. Dr. Danet-Desnoyers presented data showing that AML cells that do not engraft in NSG mice are capable of engrafting NSG-SGM3 mice, while conserving AML cell surface markers in primary and secondary recipients. He then followed with the question of whether leukemic stem cells are restricted to the CD34+ CD38- phenotype and clearly showed that CD38+ cells can repopulate NSG mice.

The webinar concluded with answers to a number of questions from the audience read by Dr. Martin Carroll, who acted as moderator.

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