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Connections February 2015
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February 2015

About ISEH

The mission of ISEH is to promote the scientific knowledge and clinical application of basic hematology, immunology, stem cell research, cell and gene therapy, and all related aspects through research, publications, discussion, support of new investigators and organization of scientific meetings.

Table of Contents

President's Message
New Investigator Digest
News from the Field
Don't Miss Sessions
Member Profile
Society News
Experimental Hematology
Member Corner

Donate now to the ISEH New (Junior) Investigator Travel Grant fund


 

Save the Date for the 44th Annual Scientific Meeting
17-19 September 2015
Kyoto, Japan

President's Message: Registration and abstract submission for the 2015 ISEH Annual Scientific Meeting are now open 

I would like to personally invite you to attend the 44rd Annual Scientific Meeting of ISEH which will take place September 17–19, 2015 at the Kyoto International Conference Center, in Kyoto, Japan. The Scientific Program Committee led by David Traver has developed a first-rate scientific program to make your time at the meeting rewarding, and Kyoto will provide the backdrop to a wonderful time of friendship and academic exchange.

New for this year are three sessions that will explore translational experimental hematology with established leaders including Alan D’Andrea, John Dick, Carl June, David Scadden, Daniel Tenen, and Irving Weissman. At the popular demand, we will launch a workshop on emerging technologies, starting this with an imaging session. Award winner Elaine Dzierzak will deliver the Don Metcalf Lecture, and award winner Andreas Trumpp will deliver the McCulloch & Till Lecture. The Presidential Symposium will explore the role of the vasculature in hematopoiesis with presentations from leaders in this area with Peter Carmeliet, Hiro Nakauchi and Shahin Rafii. In addition to the 37 distinguished invited speakers, the scientific committee has reserved 22 short talks which will be selected from the abstracts submitted, allowing plenty of opportunities for oral presentations.Abstract submissions are currently being accepted, I encourage you to submit. 

Unique with its intimate format, the ISEH Annual Scientific Meeting provides the opportunity to learn from your colleagues about their latest scientific achievements as well as a venue for you to share your work. For scientist in the field of experimental hematology, this is the premier meeting that shouldn’t be missed, and you should encourage your colleagues to attend. For young investigators, it is a great opportunity to meet and connect with highly regarded ISEH scientists, and to search for potential collaborators and mentors. From showcasing selected abstracts from young investigators in oral presentations, to the award of the best presentations by PhD students and postdoctoral fellows, ISEH continues to place emphasis on trainees and supporting trainee development.

I would also like to remind you that we have launched a new fundraising initiative to support the travel of junior investigators to the meeting. Please donate to our "New (Junior) Investigator Travel Award" fund which can be found at: www.iseh.org/travelgrants. Your donation will finance travel scholarships to deserving students and post-docs to attend the Annual Meeting. All donors will be listed on the ISEH website, and recognized at the Annual Meeting. Those who contribute $1000+ receive the opportunity to present the award to a New Investigator. Any contribution is appreciated.

I am certain that you will enjoy this major scientific event as well as the culture and hospitality that Kyoto has to offer. Please take time to look ahead by making your plans and reservations to attend the meeting and to help us make it a memorable event.

Sincerely,

Paul Frenette
ISEH President  

New Investigator Digest

Early Career Grant Writing: The True "Scientific" Rite of Passage?

Eugenia (Kena) Flores-Figueroa1, Karin Klauke2, Stephen Sykes3

1.Oncological Research Unit at the Mexican Institute of Social Health, Mexico City, Mexico. 2. European Institute for the Biology of Ageing (ERIBA), Section Ageing Biology and Stem Cells, University Medical Centre Groningen, University of Groningen, Groningen 9700 AD, the Netherlands. 3. Fox Chase Cancer Center Blood Cell Development and Function, Philadelphia, USA.


Whether it is killing their first lion, surviving in the wild or, simply reaching a certain age, the “rite of passage” symbolizes the defining moment where the younger members of society shed their dependence and transition into adulthood. In science, the transition from student to researcher is certainly not reached by age, but is only attained upon completing the rigors of a PhD program, where the publications made during this time represent our “rite of passage”.

OK, so now we can design and carry out well-controlled science that we bundle up into nice publications. BUT are we actually prepared to face the “true rite of passage” that all academic scientists, young and old, must meet…getting funded?

Writing grants is a skill that does not come naturally to most and often requires a lengthy fostering process. Therefore, the sooner you start the better chance you have of mastering it.

For those of you who are early in your career, our goal here is to provide you with some key starting points for writing concise, solid and well-assembled grants. In order to do so, we have polled several of our expert ISEH members for advice on grant writing and summarized some of the main funding sources for junior researchers from around the world. Read and learn!  Read more on website.

News From the Field

Stemline Therapeutics Initiates SL-401 Clinical Trial in Four Rare Myeloproliferative Neoplasms

Unum Therapeutics Announces Start of First Phase I Clinical Trial of Cellular Immunotherapy Targeting CD20+ Chronic Lymphocytic Leukemia and Non-Hodgkin Lymphoma

FDA Approves BLINCYTO™ (Blinatumomab) Immunotherapy for the Treatment of Relapsed or Refractory B-Cell Precursor Acute Lymphoblastic Leukemia

bluebird bio Announces Data Demonstrating First Four Patients with β-Thalassemia Major Treated with LentiGlobin™ Are Transfusion-Free

Fate Therapeutics Announces Interim Data From Ongoing Phase 2 PUMA Study

Kiadis Pharma Presents Positive Data from a Pre-Specified Interim Analysis of the Phase II Clinical Program with Its Lead Product ATIR™

Cyclacel Announces Enrollment of 486 Patients, DSMB Recommendations and that the Seamless Phase III Trial of Sapacitabine in AML Will Continue to Final Analysis

Kite Pharma Announces Presentations Highlighting Cancer Immunotherapy T Cell Manufacturing Process

ARIAD Announces Phase II Dose-Ranging Trial of Iclusig (Ponatinib) to Begin by Mid-2015

BioLineRx Completes Dose Escalation Stage of Phase I Trial for Novel Stem Cell Mobilization Treatment


Bellicum Pharmaceuticals Announces Successful Dosing of First Patient Cohort with BPX-501 T Cells Following Haplo-Identical Hematopoietic Stem Cell Transplant


Celator® Pharmaceuticals Receives FDA Fast Track Designation for CPX-351 for the Treatment of Elderly Patients with Secondary Acute Myeloid Leukemia


Don't Miss Sessions

4th International Conference on Immunochemotherapy

Philadelphia, PA, USA-April 16-17, 2015
This meeting will bring together leaders in cross-disciplinary areas of cancer research that span basic and preclinical work on cancer microenvironment, immunology and drug discovery to translational studies and clinical trials on new therapeutic agents and combinations.


BIT's 8th World Cancer Congress

Beijing, China - 15-17 May 2015
The congress consists of twelve cooperative, specialized programs tailored to highlight the latest and most exciting discoveries in every area of cancer research and it will provide a unique opportunity for researchers from all over the world to meet, network, and forge new scientific interactions.

Stem Cells in Drug Discovery - Cambridge Workshop Series

Cambridge, UK- 2-3 June 2015
Attendees to this meeting will benefit from the expert knowledge of leaders in stem cell research who are currently screening for efficacy and toxicity of experimental compounds using iPS cell lines. There will also be discussions involving industry and regulatory developments that are shaping the future of drug discovery.


American Society of Gene & Cell Therapy 18th Annual Meeting

New Orleans, LA, USA -  13-16 May 2015
This is the largest gene and cell therapy conference in the world, with 19 scientific symposia and attended by 1,700 of the world’s top researchers, clinicians, fellows, and trainees. This year's plenary lectures will be given by Drs. Steven Rosenberg and Anthony Atala.


International Society for Stem Cell Research 
2015 Annual Meeting

Stockholm, Sweden - 24-27 June 2015
The meeting provides an opportunity for scientists, clinicians, educators and industry professionals to share new data, learn from peers, and discover global advances within the stem cell field.

Read more on website.

Member Profile

Meet ISEH Member Dr. Tao Cheng

Dr. Tao Cheng, MD, is the scientific director of the Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College, the director of the State Key Laboratory for Experimental Hematology and the founding director of the Center for Stem Cell Medicine at CAMS in China. He received his medical degree from the Second Military Medical University in Shanghai, China, followed by his residency in internal medicine and clinical fellowship in hematology at Changhai Hospital, Shanghai. Dr. Cheng did his postdoctoral research training at the Hipple Cancer Research Center, Dayton, Ohio and Massachusetts General Hospital/Harvard Medical School, Boston before moving to the University of Pittsburgh.

Dr. Cheng has 28 years of experience in hematology and 21 years in stem cell research, working in the fields of hematopoietic stem cell biology and leukemia biology. He first attended the ISEH Annual Meeting in 1995 and became a member of the society in 2002. He has been involved with the society as an executive committee member/treasurer (2010-2012), member of the Editorial Board of Experimental Hematology (since 2007) and has recently become an Associate Editor of the journal.

Dr. Cheng took the time to participate in a Q&A session with Connections. Below he explains how he got involved with the field of hematology, his decision to continue his research career in China, his advice to recruit more ISEH members in Asia and how he sees his new role as Associate Editor of Experimental Hematology.

How did you find your way to the hematology and stem cells scientific field?
When I was a third-year medical student before taking clinical courses, one of my classmates and roommates had a high fever after we played a soccer game. Shortly after he was sent to the hospital, he was diagnosed with acute leukemia and, tragically, he died of the disease in only a month. That shocking experience triggered me to develop a strong desire in doing hematology and stem cell research.


Read more on website.

Society News

Register Now for the upcoming ISEH webinar: Hematopoietic specification from pluripotent cell lines vs. reprogramming of somatic cells

Presenters: George Daley, Boston Children's Hospital and Derrick Rossi, Boston Children's Hospital

Moderator: Kateri Moore, Ichan School of Medicine at Mount Sinai

When: 4 March 2015 10:00 am EST - 11:30 EST

ISEH webinars are FREE to all ISEH members. 

Register now!

Learn more about the presenters here. 

Experimental Hematology offers an easy submission process

Submit a manuscript to Experimental Hematology and have your research published in the official journal of ISEH and one of the leading journal on hematology, stem cell biology, and transplantation.

Experimental Hematology publishes original research reports, reviews, perspectives, and letters to the editor, and has an average of 25,000 articles downloaded per month. 

  • Your Paper, Your Way: All authors may submit their manuscripts as a single PDF file, including all figures, figure legends, and references. 
  • Faster publication times: initial review averages under 4 weeks and articles are published online from 5 days of acceptance. 
  • Waived submission fees for ISEH members, with no page fees for articles published. 

You'll be joining ISEH in Japan, right?

Annual Meeting Registration and the Call for Abstracts are Now Open - Submit Your Abstract Today!

Leaders in the field from around the world will be Kyoto, Japan, this Fall and we hope you’ll be among them. The ISEH 44th ISEH Annual Scientific Meeting will be held 17-19 September 2015, at the Kyoto International Conference Center. To encourage scientific innovation, ISEH offers group registration discounts, so coordinate with your colleagues and start making your travel plans.

Quick Links:
Program
Call for Abstracts
Registration
Housing & Travel

Share Your Science in Kyoto - Submit Your Abstract Today!

Submit your work for the opportunity present at the ISEH Annual Meeting. Remember that ISEH members’ submissions are FREE. ISEH leaders know that travel to Japan can be expensive for some, therefore ISEH has doubled the funds available for travel awards for New Investigator abstract presenters this year. Abstracts are being accepted now through 10 April 2015. Speakers will be notified in May.

Please visit the ISEH website for more detailed information about the Annual Meeting.


Experimental Hematology

Inside Experimental Hematology: January and February 2015

An ALL xenograft model that simulates the process of clonal selection of chemoresistant
clones

Mixed chimerism in C3a-deficient mice

Donor chimerism in CD25D-activated leukocytes as a predictor of GvHD after stem cell
transplantation

Increase level of intact CXCL12 in the spleen of patients with myelofibrosis: a mechanism underlying the development of extramedullary hematopoiesis

A novel anti-HLA monoclonal antibody with anti-GVHD activity

Do osteoclasts have a role in HSC trafficking?

Mature adipocytes as potential cell source for therapeutic angiogenesis

Read more on website.

Member Corner

Congratulations to ISEH members!

George Daley for the publication of the paper " Deconstructing transcriptional heterogeneity in pluripotent stem cells", published in Nature. 2014 Dec 4;516(7529):56-61.

Benjamin Ebert for the publication in the N Engl J Med of the manuscript " Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes". N Engl J Med December 25, 2014; 371:2488-2498.

Michael Cleary for the paper " Human iPSC-derived motoneurons harbouring TARDBP or C9ORF72 ALS mutations are dysfunctional despite maintaining viability". Nat Commun. 2015 Jan 12;6:5999.

Stuart Orkin and Hanna Mikkola for their paper " Scl binds to primed enhancers in mesoderm to regulate hematopoietic and cardiac fate divergence", published online on January 5th in The EMBO Journal.


Read more on website

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