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September 2014

About ISEH

The mission of ISEH is to promote the scientific knowledge and clinical application of basic hematology, immunology, stem cell research, cell and gene therapy, and all related aspects through research, publications, discussion, support of new investigators and organization of scientific meetings.

Table of Contents

President's Message
New Investigator Digest
News from the Field
Don't Miss Sessions

Member Profile
Society News
Experimental Hematology
Career Opportunities 
Member Corner

President's Message 

 As my term as President of ISEH ended at our annual meeting, I would like to take this opportunity to reflect on the accomplishments that have taken place over the past year.

My goals were to support ISEH's mission to promote the scientific knowledge and clinical application of experimental hematology through research, publications, discussion, support of young investigators and organization of scientific meetings. This included continued support of Experimental Hematology, the ISEH official journal. In 2014 the journal published numerous excellent papers as well as a collection of reviews for the journal's 40th anniversary: Anniversary Review Series, and a special issue - Genomics and Model Organisms: New Horizons for Experimental Hematology. Many thanks to Keith Humphries, David Traver and Bertie Gottgens for an outstanding job in putting together the special issue

We strengthened and expanded networking and educational opportunities for our members with a redesigned website and the launch of the "Ask the Expert” Online Discussion Forum, which is in addition to the very successful webinars organized by the New Investigator and Publication Committees. Our social media presence is growing. We have now a combined total of 597 (30 new since last month) users between Facebook, LinkedIn and Twitter. 

Finally, ISEH’s goal of sound, fiscal governance resulted in several initiatives including the addition of a Finance Committee as a standing committee. Led by our Treasurer, Jean-Pierre Levesque, they worked hard to examine all aspects of our budget. We were able to strengthen funding streams for short and long-term support of the society, as well as trim expenses in a number of areas.   In addition, we introduced a Membership & Marketing Task Force, headed by Hanna Mikkola and David Traver. This truly international contingent implemented a campaign to contact lapsed members from years past, and personally reach out to other colleagues in the field to encourage new membership and involvement with our growing organization. With the kickoff of the 2014 renewal season this past October, ISEH has seen some of the highest renewal numbers in recent years. The introduction of the new 2-year membership option has also generated some excitement among our membership. So far we are on track to meet our FY2014 budget goals of positive cash flow. 

A special thank you to the ISEH Board of Directors, committee chairs and committee members for working hard to ensure the strength and viability of ISEH. I also want to thank ISEH staff for providing important and enthusiastic administrative support to the society.

Finally, I would like to thank all of you for electing me President of ISEH and for your support and confidence over the past year. Please join me in welcoming the new Board of Directors and wishing Paul Frenette great success as he assumes the Presidency of our society. Meanwhile, I will continue to be involved with ISEH on many levels, and I will keep supporting the society in achieving a long-term strategic plan to help shape our future directions -- please email me your thoughts


Margaret (Peggy) Goodell
ISEH Immediate Past President 

New Investigator Digest

Another great year of New Investigator Sessions at the ISEH Annual Meeting

We are excited to report that the new investigator program for ISEH 2014 has been a success. As per ISEH's mission statement, our meetings have a significant focus on new investigators and networking opportunities. This year's Annual Meeting sessions created the opportunity to meet established investigators and students, to get to know various career pathways (yes, there is a lot more than academia), and to discuss cutting-edge methods. Read more on website >

News From the Field

Bone Therapeutics Starts Patient Treatment in First Ever Clinical Trial with Allogeneic Bone Cell Therapy Product

Amgen Receives FDA Breakthrough Therapy Designation for Investigational BiTE® Antibody Blinatumomab in Acute Lymphoblastic Leukemia

MacroGenics Initiates Phase I Study of MGD006 for the Treatment of Acute Myeloid Leukemia

University of Pennsylvania’s Personalized Cellular Therapy for Leukemia Receives FDA’s Breakthrough Therapy Designation

Merck Initiates Phase III Study of Letermovir, an Investigational Antiviral for Prevention of Cytomegalovirus (CMV) Infection in High-Risk Bone Marrow Transplant Patients

Innate Pharma SA Announces Completion of Target Enrollment in the Phase II EffiKIR Trial

MEI Pharma Reports High Response Rates in Phase II Study of Pracinostat in Front Line Acute Myeloid Leukemia

Synta Announces Advancement of Ganetespib into Phase III Extension of AML LI-1 Study for Patients with AML and High-Risk MDS

ERYTECH announces enrollment of first patient in Phase I/II study of ERY-ASP in Acute Lymphoblastic Leukemia in the United States

GlycoMimetics Initiates First Clinical Trial of GMI-1271 as Potential Treatment for Blood-Related Cancers 

U.S. Food and Drug Administration Approves Gilead’s Zydelig® (Idelalisib) for Relapsed Chronic Lymphocytic Leukemia, Follicular Lymphoma and Small Lymphocytic Lymphoma 

Don't Miss Sessions

EMBO Conference-Stem Cells in Cancer and Regenerative Medicine
EMBL Heidelberg, Germany, 9-12 October 2014

9th International Conference of Anticancer Research 
Porto Carras, Sithonia, Halkidiki, Greece, 6-10 October 2014

Advances in Stem Cell Research 2014 - Online Free Event
16-17 September 2014


  Read more on website. 


Member Profile

Meet Dr. Nadia Carlesso - "ISEH has created a tight community of hematologists"

Nadia Carlesso, M.D., Ph.D.
Associate Professor of Pediatrics
Medical and Molecular Genetics
Herman B Wells Center for Pediatric Research 
Indiana University School of Medicine
1044 W. Walnut, Bldg. R4-Room 166
Indianapolis, IN  46202
Ph:      317-274-2134
FAX:     317-274-8679

Dr. Nadia Carlesso is an associate professor of Pediatrics Medical and Molecular Genetics at the Herman B Wells Center for Pediatric Research Indiana University School of Medicine. She has been working in the field of hematology and stem cell research for 22 years, and has been an ISEH member for 14 of those years. She has served on the ISEH Board of Directors and is a member of the ISEH Membership and Marketing Task Force.

Dr. Carlesso kindly answered some questions for ISEH.

How did you find your way to the hematology and stem cells scientific field? 

It wasn’t a straight line. I started research when I was in Medical School (in Torino, Italy) and I spent the first two years studying the Dictyostelium Discoideum. A summer internship in the Department of Pathology at the University of Berlin introduced me to Hematology, but it was the subsequent internship in the Hematology Department at the University of Torino – that was determinant for my future path.  Read more on website >

Society News

ISEH Announces Board of Directors Election Results for 2014

ISEH closed its 2014 election 16 July. In this year's election 25% of members voted, and the results were extremely close, speaking to the high quality of candidates on the ballot.

Your newly elected ISEH Board Members include: 

Vice President: Timm Schroeder                    Director, America: Emery Bresnick


Director, Europe: Hartmut Geiger               Director, Pacific Rim: Sarah Ellis

The new leadership began their terms on 24 August, the final day of the ISEH 43rd Annual Scientific Meeting.

ISEH thanks its outgoing board members:
• Past President: Elaine Dzierzak
• Director: James Palis
• Director: Marella de Bruijn
• Director: Bertie Göttgens

They each committed their time and expertise to guiding and directing ISEH towards future success over the last three or more years.

ISEH would like to thank the 2014 Sponsors, Exhibitors, and Grant Supports for their support of the 44th Annual Scientific Meeting













Experimental Hematology

Inside Experimental Hematology: July and August 2014

Phenotypic characterization of the erythroid island macrophages that mediate the block of medullary erytrhropoiesis by G-CSF

See Jacobsen et al., pages 547–561.

Signaling via TLR9 augments production of human NK-like cells

See Vadillo et al., pages 562–573.

Lmo2 has epigenetic effects on CD4 in T-cell leukemia

See Cleveland et al., pages 581–593.

Editorial for the Special Issue on Genomics and Model Organisms: New Horizons for Experimental Hematology

A comment from the Editor-in-Chief, Dr. Keith Humphries, pages 595-597.

Don't forget that you can read Experimental Hematology on your Ipad.

  • New issues instantly delivered via Newsstand
  • Articles are delivered with categorized tables of contents, along with abstracts, full text, and PDFs
  • Create in-article notes
  • Share articles on Facebook and Twitter

Visit Experimental Hematology and download the app today.  



Visit the new ISEH Career Center Today

View a posting, or request a quote to post a job/fellowship at your own facility. In the past month alone, had over 22,000 page views. Posting on is a great way to get your open position in front of the some of the world’s premier scientists and the rising stars in the field. 

Current career and fellowship opportunities: 

Dartmouth College/University of Colorado Denver - Our group is seeking an individual for a postdoctoral fellowship who has experience in gene regulation mechanisms or hematopoietic stem cell biology to join our projects to clarify how epigenetic regulators coordinate self-renewal and differentiation programs in normal stem cells and in leukemia. Please send a letter of intent, contact information for 3 references, and cv to Patricia Ernst at

Indiana University - Post-Doctoral Positions Available in Area of Hematopoietic and Induced Pluripotent Stem Cells. Dr. Broxmeyer is seeking motivated and productive postdoctoral candidates with a PhD, MD, or MD/PhD, in the area of regulation of hematopoietic stem and progenitor cells, and induced pluripotent stem cells. Priority will be given to those candidates with prior experience and publications in these areas. Please send a CV and the names of three references to: Hal E. Broxmeyer, PhD, Distinguished Professor, Department of Microbiology and Immunology, IU School of Medicine, 635 Barnhill Drive, MS 420, Indianapolis, IN 46202 or to Indiana University is an EEO/AA employer, M/F/D/V

Click here to visit the Career Center

Member Corner

Congratulations to ISEH Members 

ISEH 2014 New Investigators Award winners:

Dirk van Bekkum Award: Albert D. Kim, University of California, San Diego, USANotch3 is Required in the Required in the Somitic Microenviroment for the Specification of Hematopoietic

T. Ray Bradley Award: Jeffrey Bernitz, Ichan School of Medicine at Mount Sinai, USA
Label Retention Selects for Hematopoietic Stem Cells in Aged Bone Marrow and Distinguishes HSCs from Myeloid Restricted Progenitors

Greg Johnson Award: Jalal Ahmed, Mount Sinai School of Medicine/ MSTP, USA
Dactus Venosus-associated Pericytes form a Niche Regulating Hematopoietic Stem Cell Proliferation in the Fetal Liver


Eugene Cronkite: Daniel D Lipka, German Cancer Research Center (DKFZ), Germany
Whole-genome Bisulfite Sequencing of HSCs and their Immediate Progeny Identifies Novel Regulatory Elements Involved in Self-renewal and Early Hematopoietic Commitment

George Brecher: Magali Humbert, IRIC, Canada
LM01/2 Regulates DNA Replication in Hematopoietic Cells

Christa Muller-Sieburg: Yoshihiro Hayashi, Cincinnati Children's Hospital Medical Center, USA
Modeling and Targeting MLL-PTD/RUNX1 Related MDS/AML in Mouse

Edward  Srour, Mervin Yoder,  Reuben Kapur and Carlesso Nadia for the publication in Cell Stem Cell of their manuscript " Notch-dependent repression of miR-155 in the bone marrow niche regulates hematopoiesis in an NF-κB-dependent manner." 2014 Jul 3;15(1).

Again to Nadia Carlesso for her paper "Inhibition of Notch signaling promotes browning of white adipose tissue and ameliorates obesity." published in Nat Med. 2014 Aug;20(8).

Yuya Kunisaki, Scott Armstrong  and Paul Frenette for the publication in  Cell Stem Cell of their paper "Acute Myelogenous Leukemia-Induced Sympathetic Neuropathy Promotes Malignancy in an Altered Hematopoietic Stem Cell Niche." 2014 Jul 9. [Epub ahead of print].

Kelli Carroll, Virginei Esain, Mauricio Cortes, Wanda Kwan and Trista North  for their paper "Estrogen defines the dorsal-ventral limit of VEGF regulation to specify the location of the hemogenic endothelial niche." published in Dev Cell. 2014 May 27;29(4).


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