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ISEH Connections June 2015
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June/July 2015

About ISEH

The mission of ISEH is to promote the scientific knowledge and clinical application of basic hematology, immunology, stem cell research, cell and gene therapy, and all related aspects through research, publications, discussion, support of new investigators and organization of scientific meetings.

Table of Contents

President's Message
New Investigator Digest
News from the Field
Don't Miss Sessions

Member Profile
ty News
Experimental Hematology
ISEH Career Center 
Member Corner

President's Message

As we are getting very close to the Annual Meeting, it is a good time to prepare for the new academic year. I should first remind you that the polls are still open for the 2015 Board of Directors Election, and are set to close on 13 July 2015. Please exercise your membership rights and vote! You can access this year’s ballot here. Your vote is critical to ensure that ISEH continues to be led by outstanding representative from our field. Elections results will be announced at the ISEH Business Meeting during the Annual Meeting in Kyoto.

In addition, you will be pleased to know that the society is looking for volunteers. ISEH relies on the experience and insight of our members who contribute to various committees. Volunteering is a great way to get involved in the activities of the Society. It can be both personally fulfilling and an important networking tool that generally leads to unexpected positive outcomes on your scientific pursuits through interactions and collaborations. I would like to hear from anyone with a keen interest to help us to build upon ISEH's great achievements to date. Please contact me if you are interested in becoming involved in ISEH's future (

Finally, the upcoming 44th Annual Meeting, to be held 17-19 September at the Kyoto International Conference Center, is shaping up to be a memorable one and I encourage you to join ISEH in Kyoto. This meeting gives a unique opportunity to visit one of the most compelling cities in Japan and enjoy its exceptional history and culture. Most importantly, the outstanding program put together by the Scientific Program Committee, promises to make this event a must-attend meeting for anybody interested in cutting-edge research in hematopoiesis and hematopoietic stem cells. Those of you who have previously attended know that the conference will also provide ample networking opportunities to meet potential collaborators and mentors. Check the list of hotels on the ISEH's website to book your stay and reserve early since availability may be limited. I look forward to a fantastic meeting and sharing not only our science but a good time as well! See you in Kyoto.

Best wishes,

Paul Frenette
ISEH President  

New Investigator Digest

Getting Around the Globe, Meeting by Meeting, Next Stop: Kyoto, Japan

“Travel is the only thing you buy that makes you richer.” – Unknown

Each year, ISEH meetings give us the opportunity to be in touch with the best science on our field, to reunite with colleagues and established collaborations. It also lets us be close to local research groups - not only to their science, but to their culture. Since 1971, when our society was formally established, we have been on a scientific journey around the globe. We have visited - and for some us, for the first time- cities like Vienna, Montreal, Melbourne, Hamburg and Amsterdam, to name a few.

This year, ISEH is going back to Japan. Most of our New Investigators were in high school or in their early years of college and may not know that in 2001, the 30th Annual Meeting of ISEH was held in Tokyo. At the inauguration, many of the attendees were surprised by the appearance of a royal Family member, His majesty the Emperor, who thanked the society for their contributions on radiation-related disorders. This year, although we won’t expect the Japanese emperor´s visit, the ISEH meeting has come back to Japan, this time to Kyoto, the once ancient capital of the country, which will offer a different travel experience from Tokyo.

There is something exotic and magical about Japan, the ancient culture, the language, the value of honor and respect, the unique architecture and culture. The truth is that even in our “global times”, some Japanese customs and culture may still surprise you.

 Read more on website.

News From the Field

BioLineRx Reports Successful Top-Line Safety and Efficacy Results for Novel Stem Cell Mobilization Treatment

Cardio3 BioSciences Enrolls First Patient in Phase I Trial for NKG2D CAR T-Cell

Targazyme, Inc. and M.D. Anderson Cancer Center Receive FDA IND Clearance for Phase I/II Study of TZ101-Treated Regulatory T Cells to Prevent Graft vs. Host Disease in Patients Eligible for Hematologic Stem Cell Transplantation

Actinium Doses the First Patient in the Fourth, Final Cohort of Its Actimab-A Trial

Genmab Announces Phase III Study of Arzerra® Met Primary Endpoint of Improved Progression-Free Survival in Patients with Relapsed CLL

Juno’s CAR-T Contender Comes through in Another Phase I Leukemia Study

BioLineRx Initiates Expansion Stage of Phase II Clinical Trial for Novel Treatment for Acute Myeloid Leukemia

Generon Received US FDA Clearance to Initiate Phase IIa Study with F-652, a First-in-Class Biologic, to Treat Patients with Acute GvHD

GlycoMimetics Initiates Phase I/II Clinical Trial of GMI-1271 as Potential Treatment for Acute Myeloid Leukemia in Combination with Chemotherapy

Don't Miss Sessions

EMBO Workshop on Cellular and Molecular Mechanism of Tumour-Microenvironment Crosstalk
Tomsk, Russia, 9-12 July 2015

This EMBO Workshop aims to develop beyond-state-of-the art concepts for the advanced personalized therapy by tumor microenvironment. The innovative personalized approach will have a significant socio-economic impact by increasing the efficiency of cancer therapy and improving patients’ quality of life.

25th Annual Mayo Clinic Hematology/Oncology Reviews
Amelia Island, FL, USA 29 July - 1 August 2015

A comprehensive review of hematology and oncology topics emphasizing recent developments and updates on the evaluation and treatment of cancer and blood disorders. This course is intended for practicing hematologists, medical oncologists, scientists, researchers, nurses, physician assistants, pharmacists and clinical research associates.

 Read more on website

Member Profile

Meet Dr. Mick Milsom

Dr. Mick Milsom, PhD, is a junior group leader at the Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM) in Germany. He gained his PhD in Biochemistry and Molecular Biology from the University of Leeds in the UK. For his first postdoctoral position, Dr. Milsom joined the group of Dr Leslie Fairbairn at the Paterson Institute for Cancer Research in Manchester, in order to study gene therapy of hematopoietic stem cells. He then moved to the USA to undertake a second postdoctoral fellowship in the group of Dr. David A. Williams at Cincinnati Children’s Hospital Medical Center. He next took up a junior faculty position at Harvard Medical School/Children’s Hospital Boston within the Division of Hematology/Oncology, again under the mentorship of Dr Williams.

Dr. Milsom has 14 years of experience in hematology and stem cell research, working in the fields of hematopoietic stem cell biology, DNA damage, aging, bone marrow failure and gene therapy. He first attended the ISEH Annual Meeting in Hamburg in 2007 and became a member of the society four years ago. Dr. Milsom is very involved with ISEH and is currently the head of the New Investigator Committee.

Dr. Milsom took the time to participate in a Q&A session with Connections. Below he shares with us how he got involved with the field of hematology; his decision to continue his research career in Germany; his view of the funding atmosphere in the US, Germany and other EU countries; the rewards of being involved with ISEH, and the excitement of publishing a Nature paper as senior author.

How did you find your way to the hematology and stem cells scientific field?

My Ph.D. was focused on the molecular regulation of gene expression in cell lines and, in the scheme of things, wasn’t too successful. I decided that I wanted to do something that was a little more translational for a postdoc and I answered an advertisement for a position in a group at the Paterson Institute for Cancer Research in Manchester that was studying gene therapy of hematopoietic stem cells. At the time of applying, I hadn’t realized that the Paterson had been an extremely productive and well renowned hub for hematopoietic stem cell research. Many of the people who had been responsible for that reputation were still in place when I started working there. The environment was amazing and I just fell in love with the subject and haven’t looked back.

Read more on website

Society News

ISEH Networking Story: Membership Pays Off 

Patricia Ernst, an ISEH member, recently traveled to Germany and with the aid of many fellow ISEH members was able to complete some important work in Germany thanks to her ISEH Connections.

Do you have a friend or colleague that could benefit from ISEH membership. Refer them today!

Patricia shares her story below:

Recently we came across a major question in our work that we thought could be answered using a unique mouse model generated by a lab in Germany, headed by Prof. A. Francis Stewart. Although I was a fan of the lab’s published work, I did not really know anyone there. My PhD student, Yufei Chen, felt that this animal model might be critical for her thesis work, yet when we considered what it would take to import the animals, it seemed impractical to request the strain, go through quarantine, back-cross, intercross, etc. So we decided to ask Francis if we could come to his lab in Germany, work with the strain, generate some transformed cell lines and send them back the U.S. for further characterization. He welcomed us, but some of the techniques we planned were not routinely performed by their group, so access to the proper TC hoods, reagents, Miltenyi magnets, etc. might not be easy. Bringing an entire suitcase of reagents also did not seem practical. So on a whim, I checked the ISEH membership to see if anyone I knew in the field was located in Dresden, and I found Claudia Waskow, who I also did not know but had seen at ISEH meetings. So again on a whim, I emailed her and asked if we might be able to use her equipment to do the experiment – luckily she was thoroughly welcoming about the idea and in fact had a collaboration ongoing with Francis’ lab. Since Yufei’s visa status made it tough for her to go to Europe, I decided to do it myself and started making the preparations. Members of Claudia’s institute were instrumental in helping me throw together a travel and lodging plan, which was tough for me since there are a number of German holidays in May that I did not know about, and since I do not speak or read German, some hotel web sites were Greek to me. An administrator in Claudia’s institute (Julia Seifert) found a nice family run hotel within walking distance that was affordable and kindly set up the reservation for me.

Read more on the website. 

ISEH Board of Directors Election: Vote Today!

To learn about the candidates and vote, follow these simple steps:

1. View the candidates here and access the ballot

2. You will be promoted to enter your ISEH username and password. If you do not know your username and password please contact ISEH Headquarters.

3. When you are ready to vote, click on the 'Begin Survey' button and make your selections. If you have any difficulty voting please contact ISEH Headquarters.

The election closes 13 July 2015. 

Experimental Hematology

Inside Experimental Hematology: May and June 2015

RPL11 and RDH11 induce erythroid proliferation without Epo
Kummalue et al., pages 414–423

Components of the microRNA-induced silencing complex in red blood cells
Azzouzi et al., pages 382–392

TXNIP, a novel player in erythroid differentiation
Gasiorek et al., pages 393–403

Potential side effects of dasatanib on host immunity
Oksvold et al., pages 352–363

Autophagy regulates platelet production
Cao et al., pages 488–494

You can count (on) this: Chimerism analysis going digital
Stahl et al., pages 462–468

Transferrin receptor 1 (TfR1) signals erythron iron need
Keel et al., pages 469–478

ISEH Career Center

Postdoctoral Position Available 

Department of Hematology A post-doctoral position is available in the Department of Hematology at St. Jude Children’s Research Hospital (Memphis, Tennessee, USA) to study hematopoietic stem cells. Our laboratory recently completed an in vivo screen that has identified numerous novel molecular regulators of hematopoietic stem cell repopulating activity. We are now focused on dissecting the molecular and cellular mechanisms of these novel genes with the long-term goal of developing new therapies to enhance the efficiency of hematopoietic stem cell transplantation. The successful candidate will employ mouse genetics, ex vivo cell culture, flow cytometry, and molecular biology to dissect the mechanisms employed by these candidate genes to influence HSC biology. This position is ideal for someone with a Ph.D. and/or M.D. seeking to develop expertise in stem cell biology in an intimate and vibrant laboratory setting. St. Jude Children’s Research Hospital, located in Memphis, Tennessee, USA, is a premier center for research and treatment of potentially fatal childhood diseases, including cancer and certain blood, genetic, and immunodeficiency disorders. The hospital’s mission is to advance cures, and means of prevention, for pediatric catastrophic diseases through research and treatment. St. Jude is dedicated to providing unsurpassed patient care and to advancing the health of children through biomedical research. Interested applicants should apply for job 34380 at, and include a CV and a summary of research interests and future career aspirations (300 word limit) as part of the application. Contact Information Shannon McKinney-Freeman, PhD Assistant Member St. Jude Children’s Research Hospital Department of Hematology 262 Danny Thomas Boulevard Memphis, TN 38105 901-595-2733 (office) E-mail: EOE/Minorities/Females/Vet/Disability/Sexual Orientation/Gender Identity

Read more on website.

ISEH Career Center: New Lower Posting Rates

The ISEH Career Center has decreased the cost for job posts. The new flat fee of $250 (USD) is for posts 2000 - 3000 characters. The post will run for 60 days on the ISEH Career Center and will be featured in ISEH Connections. Recruit the top new investigators from ISEH for open post-doc or faculty positions for your lab! Click here to submit an ad today.

Member Corner

Congratulations to ISEH Members 

Shahin Rafii, who is part of a consortium of scientists and transplant clinicians from the Ansary Stem Cell Institute at Weill Cornell Medical College and the Center for Cell Engineering at Memorial Sloan Kettering Cancer Center that has been awarded a $15.7 million, four-year research grant from the New York State Stem Cell Science Program to translate their innovative approach to expand and manipulate hematopoietic stem cells to cure acquired and inherited blood disorders.

Mickie Bhatia: Single Transcription Factor Conversion of Human Blood Fate to NPCs with CNS and PNS Developmental Capacity. Cell reports, Published Online: May 21, 2015.

Ihor R. Lemischka: Modeling Familial Cancer with Induced Pluripotent Stem Cells. Cell, 2015; 161, 240–254, and Tex10 Coordinates Epigenetic Control of Super-Enhancer Activity in Pluripotency and Reprogramming. Cell Stem Cell, 2015;16:1–16.

Iannis Aifantis: TET1 is a tumor suppressor of hematopoietic malignancy. Nat Immunol. 2015;16:653-662.

George Q. Daley and Leonard I. Zon: Adenosine signaling promotes hematopoietic stem and progenitor cell emergence. JEM, 2015; 212: 649.

Margaret A. Goodell: Long Non-Coding RNAs Control Hematopoietic Stem Cell Function. Cell Stem Cell. 2015;16:426-38.

Guy.Sauvageau: Haploinsufficiency screen highlights two distinct groups of ribosomal protein genes essential for embryonic stem cell fate. Proc Natl Acad Sci U S A., 2015;112:2127-32.

David G. Kent, Anthony R. Green and Berthold Göttgens: Combined Single-Cell Functional and Gene Expression Analysis Resolves Heterogeneity within Stem Cell Populations. Cell Stem Cell, Available online 21 May 2015.

Read more on website

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