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Connections June 2014
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March 2013

About ISEH

The mission of ISEH is to promote the scientific knowledge and clinical application of basic hematology, immunology, stem cell research, cell and gene therapy, and all related aspects through research, publications, discussion, support of new investigators and organization of scientific meetings.

Table of Contents

President's Message
New Investigator Digest
News from the Field
Don't Miss Sessions

Member Profile
ty News
Experimental Hematology
Career Opportunities 
Member Corner

President's Message 

The polls are open for the 2014 Board of Directors Election. Polls will close on 14 July 2014. Elections results will be announced in an upcoming Connections Newsletter as well as at the ISEH Business Meeting during the Annual Meeting in Montréal. Please take the time to VOTE for your society representatives. ISEH has been running for nearly 50 years, led by some great hematologists. I hope you participate in the current election process. Also, we are always looking for energetic volunteers, so please let me know if you are interested in becoming involved in the future (EMAIL- ).

I am delighted to give you the final details of the 43rd annual ISEH meeting to be held at the Hyatt Regency Hotel in Montréal, Canada, from August 21st to the 24th. The meeting has something for everybody- from cutting-edge presentations of new and original scientific research to plenty of networking opportunities to meet potential collaborators and mentors. I encourage you to attend the conference, which I am sure will provide a wonderful time of friendship and academic exchange.

The final program is now online, abstracts have been selected and presenters have been notified. This year's meeting will open with Toshio Suda from Keio University, Japan, who will deliver the Donald Metcalf Lecture and will conclude with Emmanuelle Passegué from the University of California San Francisco, who is the 2014 ISEH  McCulloch and Till Award recipient. The outstanding line up of renowned experts also includes Presidential Symposium speakers on single-cell dynamics in the hematopoietic system, including Connie Eaves, from the BC Cancer Agency, Garry Nolan from Stanford University and Tim Ley from Washington University School of Medicine.

The New Investigators Committee (NIC) has prepared an exciting and busy schedule which includes the NIC sponsored lecture by Simón Méndez-Ferrer and the Meet-the-Professor breakfast featuring Ben Ebert, Sean Morrison, Scott Armstrong, David Traver, George Daley, Guy Sauvageau, Connie Eaves, Toshio Suda, and Emmanuelle Passegué. They have also organized a panel on alternative careers featuring members from CIHR, Cell Stem Cell, Stem Cell Technologies, and Janssen Pharmaceuticals. There is also a panel on single cell "Omics” covering topics of cellular barcoding and a variety of genome-wide sequencing approaches. And of course, there is the social mixer at which new investigators will have the chance to socialize with colleagues from around the world during an evening of mingling and drinks at the Six Resto Lounge at the Hyatt Regency Hotel.

Montréal, with its natural beauty, Old World charm and vibrant energy is a truly unique location for this year's meeting. Montreal is the second largest city in Canada and the world’s second-largest French-speaking city. With hundreds of interesting attractions, it is no surprise that this city has been called ‘Canada’s Cultural Capital’. Montréal is renowned for its numerous universities, medical and scientific research centers, as well as for its cultural and artistic life, vibrant nightlife and eclectic cuisine. I encourage you to make time to explore what Montréal has to offer.

In closing, the 2014 ISEH meeting is shaping up to be another memorable meeting that you will not want to miss. I'm personally looking forward to reconnecting with old friends and continue to meet new ones. See you in Montréal!

Margaret (Peggy) Goodell
ISEH President 

New Investigator Digest

Tools to Collaborate in Science: Reference Manager Software

In our last issue of Connections, we discussed collaborative science and the importance of clear communication with your collaborator. Collaborations will not only include sharing samples, methods and ideas, but can also lead to co-authored grants, proposals or manuscripts. Without the proper technology, these collaborative writing projects could be a headache, leaving you with an inbox full of papers and drafts. Sharing and working on common documents is now much easier, thanks to a flurry of new technology. Here we will discuss some of the pros and cons of various reference managers and how best to utilize these tools for an effective collaboration.. Read more on website >

News From the Field

First volunteers to receive blood cultured from stem cells in 2016

Alnylam Reports Initial Positive Top-Line Data from Phase I Clinical Trial with ALN-AT3, an RNAi Therapeutic Targeting Antithrombin (AT) in Development for the Treatment of Hemophilia and Rare Bleeding Disorders (RBD)

Umbilical Cord Stem Cell Therapy Clinical Trial for Multiple Sclerosis Gets Green Light

Clinical Trial Investigates Cord Blood Stem Cells to Treat Cerebral Palsy in Children

Emmaus Life Sciences Announces Positive Top-Line Results of Its Phase III Clinical Trial For Sickle Cell Disease

bluebird bio Announces First Patient Transplanted in Phase I/II Northstar Study for the Treatment of Beta-Thalassemia

Ambit Announces Initiation of Phase II Cohort in MD Anderson Sponsored Study of Quizartinib in AML and High Risk MDS

Moffitt Cancer Center’s Phase III Study May Be Game-Changer for Acute Myeloid Leukemia

PIXUVRI® Launched in UK for Adult Patients with Multiply Relapsed or Refractory Aggressive B-Cell Non-Hodgkin Lymphoma

GSK and Genmab Receive FDA Approval for Arzerra® (Ofatumumab) as First-Line Treatment in Combination with Chlorambucil for Patients with Chronic Lymphocytic Leukemia (CLL) for Whom Fludarabine-Based Therapy Is Considered Inappropriate

Investigational PD-1 Immune Checkpoint Inhibitor Nivolumab Receives U.S. FDA Breakthrough Therapy Designation for Hodgkin Lymphoma

Don't Miss Sessions

American Society of Hematology (ASH) Meeting on Lymphoma Biology
Colorado Springs, Colorado-August 10 to 13, 2014 

The ASH® Meeting on Lymphoma Biology is focused on basic and translational research in lymphoma and lymphoid malignancies. The goal of the meeting is to further the understanding of lymphoma pathogenesis and accelerate new therapies by providing a forum for scientific exchange and by developing a roadmap for lymphoma research. Read more on website >

FEBS-EMBO Conference 2014
Paris, France- August 30th to September 4th 2014

This year's meeting replaces the normally separate annual conferences of FEBS and EMBO. The programme committee has put together a scientific programe covering the breadth of the life sciences.  In addition, there will be sessions on science policy, publishing and careers and education, as well as activities tailored specifically for scientists in the early stages of their careers. Read more on website. 

Member Profile

Meet Dr. Eugenia (Kena) Flores Figueroa 

Dr. Eugenia (Kena) Flores Figueroa is a Research Associate in the Oncological Unit at the Mexican Institute of Social Health. She received her PhD in 2006 in Biomedicine from the Universidad Nacional Autónoma de México. Dr. Flores Figueroa has been in the field of hematopoietic microenvironment and mesenchymal stem cells for 19 years. She has been a member of ISEH for 16 years and is currently a member of ISEH's New Investigator Committee.

How did you find your way to the hematology and stem cells scientific field?

My first encounter with the field was almost 20 years ago when I saw a hematopoiesis poster outside of the office of my mentor-to-be, Dr. Hector Mayani. He told me that I was about to get into the most fascinating and best research field. He was not lying! As an undergraduate student in his lab, I had the opportunity to work with "the classic” long-term marrow cultures growing myelodysplastic syndomes (MDS) patient’s cells.  . Read more on website >


Society News

2014 ISEH Board of Directors Election - Vote before 14 July 2014! 

It’s the time of year to make sure your voice is heard through your participation in the 2014 Board of Directors.

This is an important opportunity for you to choose the leaders who will guide ISEH into the future.

To learn about the candidates and vote, follow these simple steps:

1.      View the candidates here. 

2.       Access the ballot here.

3.       You will be prompted to enter your username and password. If you do not recall your username or password, there is a provision in the login area to obtain that information or you may contact Headquarters.

4.       When you are ready to vote, click on the "Begin Survey" button

5.       Make your selections. Once completed select "Complete Survey". If you experience any difficulty voting online, please do not hesitate to contact Headquarters.

Voting will close on 14, July 2014. Election results will be announced in an upcoming issue of the newsletter as well as at the ISEH Annual Business Meeting during the 2014 Annual Meeting in Montréal. All members are invited to attend the business meeting on Sunday 24 August 2014 for election results and other ISEH business.

Join in on the Conversation and "Ask the Expert”: Innovative homing and imaging techniques to unveil the HSPC niche

New for 2014, the new ISEH Ask the Expert Forum regularly features a new expert. The current expert is Sarah Ellis who will be available through July to answer and discuss questions from ISEH members. 

Most recently, B. Dykstra asked: "Do you have any idea how homing to femurs compares with homing to other anatomical sites, e.g. tibia, spine, calvarium?”

Visit the forum to join the conversation. 

Experimental Hematology

Inside Experimental Hematology: May and June 2014

Immunogenicity of ESC-derived hematopoietic progenitors
See Thompson et al., pages 347–359.

Parsing out the Integrins' work on erythropoiesis
See Ulyanova et al., pages 404–409.

Is bio-manufacture of human platelets for transfusion possible?
See Haylock et al., pages 332–346.

Hes1 contributes to leukemic transformation of FIP1L1-PDGFRA-positive leukemia
See Uchida et al., pages 369–379.

Overlapping roles of Snail proteins in hematopoiesis and strategies to assay transcription factor families for "intramember” compensation
See Pioli and Weis, pages 425–430.

Global analysis of transcription factors and cofactors during terminal erythropoiesis
See Chen and Lodish, pages 464–476.

Single cell analysis shows mutational heterogeneity in leukemic cells
See Shouval et al., pages 457–463.


Editor's Picks: Career Opportunities 

Postdoc Research Scholar - Molecular Oncology- St Louis, MO

Clinical HSCT Faculty Position- Madison, WI

Research/Review Scientist - Cell Therapy and Regenerative Medicine- Silver Spring, MD

Post-doctoral/Research Associate position- Hematopoietic Differentiation- Seattle, WA

Scientist, Immunology/Cell Separation-Vancouver, Canada

Postdoctoral researcher -Leuven, Belgium

Postdoctoral Position – Epigenetics and Stem Cell Biology- Bad Nauheim, Germany

Postdoctoral Position in Molecular and Cell Biology - Doha, Qatarien 
Read more on website >

Member Corner

Congratulations to ISEH Members 

Paul Frenette for the publication of the manuscript entitled "Osterix Marks Distinct Waves of Primitive and Definitive Stromal Progenitors during Bone Marrow Development" published in  Dev Cell in May 12 2014.

Katherine King and Margaret (Peggy) Goodell for the publication in Nature May 25 2014 of their paper entitled "mTORC1 controls the adaptive transition of quiescent stem cells from G0 to G.Alert.

 Bertie Göttgens  and Margaret (Peggy) Goodell for the publication in Cell Stem Cell in May 1 2014 of the paper "Epigenomic Profiling of Young and Aged HSCs Reveals Concerted Changes during Aging that Reinforce Self-Renewal".

Hind Medyouf,  Amelie Lie and Andreas Trumpp for their manuscript "Myelodysplastic Cells in Patients Reprogram Mesenchymal Stromal Cells to Establish a Transplantable Stem Cell Niche Disease Unit",  published in Cell Stem Cell in Apr 3 2014. 

 Christine Miller and Amy Wagers for the publication in Science, May 9 2014, of their papers: "Vascular and neurogenic rejuvenation of the aging mouse brain by young systemic factors" and"Restoring systemic GDF11 levels reverses age-related dysfunction in mouse skeletal muscle" .

Peter van Galen, David Kent,  Kolja Eppert,  Anthony  Green and John  Dick for their manuscript "The unfolded protein response governs integrity of the haematopoietic stem-cell pool during stress", published in Nature in April 28 2014.
Read more on website >


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