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April 2014

About ISEH

The mission of ISEH is to promote the scientific knowledge and clinical application of basic hematology, immunology, stem cell research, cell and gene therapy, and all related aspects through research, publications, discussion, support of new investigators and organization of scientific meetings.

In this Issue

New Investigator Digest

News from the Field

Member Profile

Society News

Don't Miss Sessions

Experimental Hematology

Jobs

Members' Corner 

 


President's Message 

Cultivating the future of experimental hematology through our junior investigator programs

Early-career investigators are the drivers of scientific innovation and supporting them is at the core of the ISEH's mission.  Cultivating young investigators is vital to ensure that our field continues  to grow with new ideas, creative technology, provocative experiments, and innovative concepts.  

As articulated in our mission, " In order to support young scientists ISEH shall sponsor Fellowships and Awards to promote education and training." To this end, our society takes great pride in providing travel grants and awards to new investigators that submit cutting edge abstracts for discussion at the Annual Meeting.  The New Investigator Session of the meeting recognizes the six highest ranked abstracts submitted for presentation, with three students and three postdoctoral trainees honoured with named awards and highlighted oral presentations. 

New investigators are not only at the receiving end of ISEH, but they are one of our society's driving forces. This is demonstrated by the numerous initiatives undertaken by the New Investigator Committee (NIC), which organizes events throughout the year and at the annual meeting designed to cater to the needs and interests of the younger members of the society. The NIC established and maintains the presence of ISEH on social media, including Facebook, Twitter and LinkedIn.  They have designed and run a Webinar this year on stem cell heterogeneity.  In addition, the NIC sponsors an invited New Investigator Lecturer at the Annual Meeting  and organizes the ‘Meet the Expert Breakfast’, two career panel discussions, and a mixer for new investigators to network and socialize every year at the Annual Meeting (click here to learn more).  This committee is certainly one of the most active and vibrant of all the ISEH committees. If you have suggestions for activities you would like to see, contact one of the members  or put your name forward for participating in the committee work!

The new investigators are the future of our Society, and we will continue to invest in their development.


Sincerely,
Margaret (Peggy) Goodell
ISEH President

New Investigator Digest

Collaborative research: the why and how to collaborate in science.
"I was told once that the mark of a good PI (principal investigator) is that they sit in their office on the phone and dial up as many collaborations as possible”      Dr. Leonard Zon. Read more on website

News From the Field

News Roundup: April 2014

EBiSC – the first European bank for induced pluripotent stem cells

Fate Therapeutics Announces Observed Effects of Pharmacologic Modulation on T Cell Compartment From Its Phase 1b Study of PROHEMA(R)

Cerebral Palsy and the Potential of Cord Blood Stem Cells

U.S. National Institutes of Health to Commence New Study of Pluristem’s PLX Cells for Acute Radiation Syndrome Treatment

REGiMMUNE Begins Enrollment for Phase II Clinical Trial for Graft versus Host Disease

TotipotentRX and ThermoGenesis Achieve Bone Marrow Stem Cell Transplant Milestone

Gamida Cell’s StemEx® Achieves Primary Endpoint in Phase II/III Clinical Study 

SRI International Launches FASTcell Screening Services for Identification and Characterization of Rare Circulating Cancer Cells 

MEI Pharma Receives Orphan Status for Lead Drug Candidate Pracinostat for Treatment of Acute Myeloid Leukemia

Igenica Enrolls First Patient in Phase I Trial of IGN523 to Treat Acute Myeloid Leukemia

Don't Miss Sessions

Upcoming Meetings in Vancouver and London

ISSCR 12th Annual Meeting
Vancouver. BC, Canada-June 18-21

The 2014 Tissue Engineering Congress
London,UK-June 2-4

 Read more on website >

Member Profile

Meet ISEH Member Trista E. North 

Trista E. North, PhD is an Assistant Professor of Pathology at Harvard’s Medical School in the Department of Pathology at the Beth Israel Deaconess Medical Center. She has dedicated over 18 years to the field of hematology and stem cell research, and has spent 6 of those years as an ISEH member. She is the newest addition to the Editorial Board of Experimental Hematology.

Dr. North has lent her considerable knowledge and experience to the ISEH Board of Directors, the ISEH publications committee, and various abstract review committees for ASH and ISSCR. As a full member of the Harvard Cancer Center, Dr. North focuses her research efforts on hematopoiesis and HSC regulation/transplantation. 

Read more on website 

Society News

Leadership is Calling!

ISEH is looking for members to serve on the Board of Directors.  We urge you to take a few minutes of your time to nominate candidates you feel have the skills and interest to manage and guide the Society on your behalf. Or, if you have a passion and are committed to serving ISEH, you can nominate yourself. Submit your nomination!

New ISEH Member Resource: Ask the Expert Forum

Ask the Experts forum is a member only benefit - featuring two experts from the field of hematology. This month's forum features David Kent (University of Cambridge) and Brad Dykstra (Harvard Medical School). Both will be available for the next month to answer and discuss questions from ISEH members. Check out the forum!

 Read more on website >

Experimental Hematology

Inside the March & April Issues

TIM-4: a novel marker for myeloid precursors in FL
See Syrjanen et al., pages 230-240.

The tyrosine kinase receptor Flk2/Flt3 promotes myeloid development
See Beaudin et al., pages 218–229.

Inhibition of proteasome deubiquitinases as a novel cancer therapy
See Feng et al., pages 172–182.

Mouse strain-specific polymorphism in Sirpa determines the efficiency of human hematopoietic engraftment in xenotransplant models
See Iwamoto et al., pages 163–171.

Clinical potency of ponatinib in drug-resistant eosinophilic leukemias carrying FIP1L1-PDGFRA
See Sadovnik et al., pages 282–293.

Visfatin: A potential biomarker for remission in leukaemia and immune reconstitution after stem cell transplantation

SALL4: A potential new therapeutic target for acute B-cell lymphoblastic leukemia
See Ueno et al., pages 307–316.

Pretreatment of myeloma cells with a combination of JSI-124 and bortezomib can overcome dendritic cell dysfunction for the induction of a useful anti-myeloma T-cell response
Jung et al., pages 274–281.

Jobs

Editor's Pick: Career Opportunities 

Associate or Full Professor in Stem cell Biology, University of California Riverside 

Bioinformatics Postdoc Position, UCLA

Faculty Positions in Cancer Research, University of Oklahoma 

Research Associate (Asst. Prof) in hematology/Oncology, University of Chicago 

Postdoctoral Fellowships in Cancer Research, DKFZ

Postdoctoral Research Fellow - Stem Cells, BTI, SBIC, NNI

Postdoctoral Position - Embryonic Stem Cells, Beijing 

Member Corner

Congratulations to ISEH Members

Congratulations to:

Bertie Göttgens for the publication in Nature Methods of the paper "Function-based identification of mammalian enhancers using site-specific integration. Nat Methods. 2014 Mar 23.

Ashley Ng and Alexander Warren for the publication of their manuscript entitled " Mpl expression on megakaryocytes and platelets is dispensable for thrombopoiesis but essential to prevent myeloproliferation". Proc Natl Acad Sci U S A. 2014 Apr 7. 

 Guy Sauvageau for the manuscript "Identification of small molecules that support human leukemia stem cell activity ex vivo." Nat Methods. 2014 Apr;11(4):436-42. 

 

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