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Connections October 2014
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October 2014

About ISEH

The mission of ISEH is to promote the scientific knowledge and clinical application of basic hematology, immunology, stem cell research, cell and gene therapy, and all related aspects through research, publications, discussion, support of new investigators and organization of scientific meetings.

Table of Contents

President's Message
New Investigator Digest
News from the Field
Don't Miss Sessions

Member Profile
ty News
Experimental Hematology
Member Corner

Donate now to the ISEH New (Junior) Investigator Travel Grant fund

Save the Date for the 44th Annual Scientific Meeting
17-19 September 2015
Kyoto, Japan

President's Message: ISEH's Financial Stability

I am honoured to have the opportunity to lead ISEH for the next year as president. As I assume this role, I would like first to thank those past Presidents, Board of Directors, members, and Committee members who have worked hard to make ISEH the strong organization it is today.

One of my main goals as president is to spearhead the implementation of the Society's new strategic plan (2014-2017), which was recently approved by the Board of Directors. You can find the final version of the plan on theMembers Only area of the ISEH website. This strategic plan aims to increase the membership of the Society, provide additional educational activities to members, increase annual meeting participation, strengthenExperimental Hematology, and develop new resources and funding opportunities to ensure the long-term financial success of ISEH.

In this inaugural newsletter, I would like to elaborate on our plans to ensure the Society’s financial stability. Like many academic and private institutions, ISEH has been under financial stress over the past few years. The Society is very lucky to receive revenue from the contract with Elsevier for the publication ofExperimental Hematology, which accounts for about half of our operating budget. The journal’s revenues have allowed ISEH to accumulate some assets (about $1M). However, these assets have never been invested. We have recently established a task force to invest a fraction of these funds to help ensure the Society’s long-term financial success.

The annual meeting is by far the most elaborate activity that can lead to significant budget deficits. With the economic crisis and the reduced budgets of the pharmaceutical industry and NIH, the means for financial support have shifted. We have established the "Friends of ISEH” as a vehicle to nurture relationships with institutes and non-profit organizations that care about our Society. We plan on growing these relationships to sustain our annual fundraising for the annual meeting. Ideally, the meeting will always have about 400 participants. Such participation also represents an ideal number to make the meeting vibrant while keeping at the same time the intimacy that promotes interactions and collaborations. As we hear so much positive feedback on the outstanding quality of the meeting, we urge you to encourage your colleagues to attend!

Next year, we look forward to welcoming you to Kyoto, Japan. We are proud of the strong local organizing committee headed by Dr. Koichi Akashi. We realize that sending graduate or postdoctoral students to Japan is not cheap if you don't live there. To ensure a vigorous attendance, we have increased our budget for travel awards. We have also launched a new fundraising initiative to mitigate the impact on the society’s balance sheets. If you can, we invite you to donate any amount for our "Junior Investigator Travel Award" fund which can be found We all know several examples of colleagues for whom the ISEH meeting was their first and most memorable conference that launched their interest in hematopoiesis research. Your donation will provide much needed financial support to give junior investigators the chance to present their research, to network and glean ideas from some of the top hematology/stem cell scientists in the world. All donors will be listed on the ISEH website, and recognized at the Annual Meeting. Those who contribute $1000+ may receive the opportunity to present the award to a New Investigator. Any contribution is appreciated.

I want to thank you for your continued support and your engagement with ISEH and I am looking forward to work with all of you to further strengthen our Society.

Best wishes,

Paul Frenette
ISEH President

New Investigator Digest

Improving your public speaking skills: insights and advice

There is no doubt that we all agree on the importance of public speaking; we all enjoy a great talk and suffer and count the minutes until a bad one is over. We recognize that public speaking is one of the most important tools to communicate our science, yet, we usually do not know how or where to look for resources to improve our public speaking skills. According to Sean Morrison, Director of the Children's Medical Center Research Institute at UT Southwestern and Investigator of the Howard Hughes Medical Institute, "young people make the mistake of thinking that people are born either good or bad communicators”, he stated, "good ones really work at it”. The purpose of this article is to discuss and provide resources and tools to master strong communication skills and to raise the awareness that becoming a great public speaker is in your hands.
Read more on website.

News From the Field

Alnylam Receives Orphan Drug Designations in the European Union for ALN-AT3, an RNAi Therapeutic in Development for the Treatment of Hemophilia

CEL-SCI Corporation Moves Ahead with Phase III Immunotherapy Head and Neck Cancer Trial

Avillion Announces Dosing of First Patients in Phase III BFORE Trial to Assess BOSULIF® (Bosutinib) as First-Line Treatment for Patients with Chronic Myelogenous Leukemia

AFL Approves Use of Regeneus’ Stem Cell Therapy, HiQCell for Injured Players

Celldex Therapeutics Initiates Pilot Study of CDX-301 in Allogeneic Hematopoietic Stem Cell Transplantation

GSK and Genmab Announce Positive Interim Result for Phase III Study of Ofatumumab as Maintenance Therapy for Relapsed CLL

Boston Strategics Corporation Initiates a Phase I Clinical Trial of the Anti-Cancer Agent "FF-10501″ for FUJIFILM in Patients with Advanced Hematologic Malignancies

Novel Drug Targeting Leukemia Cells Enters Clinical Trial

Don't Miss Sessions

2014 World Stem Cell Summit
San Antonio, Texas, USA
3-5 December 2014

This is the largest interdisciplinary, networking meeting of stem cell science and regenerative medicine stakeholders, uniting the diverse community. The program provides the research, industry, economic and societal context for understanding how all of the pieces of the stem cell science and regenerative medicine puzzle fit together. Supported by 200 organizing partners, sponsors, exhibitors, endorsing organizations and media partners, the Summit is a three-day showcase of innovation, insight and inspiration.Read more on website.

56th ASH Annual Meeting and Exposition
San Francisco, CA, USA
6-9 December 2014

This meeting will provide attendees with an invaluable educational experience and the opportunity to: 1)Review more than 3,000 scientific abstracts highlighting the updates in the hottest topics in hematology; 2)Interact with the global community of more than 20,000 hematology professionals from every subspecialty; 3)Attend the hallmark Education and Scientific Program sessions; 4) Network with top minds in the field.Read more on website.

Advances in Stem Cell Research 2014
Online Free Event
12-13 November 2014

During this event, the hottest topics in the Translational Space will be addressed in a webinar-style auditorium with the opportunity for live Q&A at the end of each talk. Featuring an array of leading international speakers, this event aims to provide you with an insight into the latest developments, with specific focus on cell-based therapies.Read more on website.


Member Profile

Meet Albert D. Kim, BSc, MSc - the 2014 winner of the ISEH New Investigator Award

Albert D. Kim, BSc, MSc is the 2014 winner of the ISEH New Investigator Award,given to the best presentation by a graduate student. Albert is finishing his PhD in the laboratory of Dr. David Traver at University of California, San Diego. He has been working in the field of hematology and stem cell for eight years, and has been an ISEH member all those years.

Albert kindly answered some questions for ISEH.

Tell us about your graduate education, generally. About the experience of being a graduate student.
My graduate career has felt like growing up all over again, learning from talented people that are much better at research than I am. During this period I understood that to approach the level of my colleagues someday I would need something more than what I could absorb from them. Graduate school has been the stage where I’ve tried to understand and develop what ‘my way’ as a scientist is.

Who has most influenced you to become a scientist, and how did they influence you?
Julien Bertrand was my first postdoc mentor that showed me by example the level of performance and diligence that I would need to reach as a scientist. Wilson Clements was my second postdoc mentor that showed me the level of thinking and planning that I would need to focus my research. I think of both of them as my living textbooks and I constantly refer to my memories associated with them when I am doing my research today.Read more on website.

Society News

It's ISEH Membership Renewal season. Renew today!

ISEH Membership renewal season is upon us once again, and it’s never been easier to renew your membership online.

Once you have logged in, pay your dues by clicking on "Renew Your Membership Now." If you are not automatically directed to this page upon your login, clickhereto access the renewal page. Need help with your login information? Emailinfo@iseh.orgfor assistance.

Remember,Active members can now renew for two-yearsand then cross "renew ISEH membership” off your to-do list for next year!

Do you know 5+ scientists who should be members of ISEH and have been waiting for the right moment? The time has come, ISEH is offering group membership rates for groups of five or more new members from the same facility, emailinfo@iseh.orgfor more details.

The latest ISEH Webninar is now available for members online

The latest ISEH Webinar is now available for members online
Did you miss the live ISEH webinar on feedback control of blood stem cell fate? ISEH members can view the recording online.

Title:Feedback Control of Blood Stem Cell Fate
Presenter: Peter W. Zandstra, University of Toronto
Moderator: Teresa Bowman, Albert Einstein School of Medicine

Experimental Hematology

Inside Experimental Hematology: September and November 2014

Futhering our understanding of the role of miRNAs in hematopoiesis.
See Wojtowicz et al., pages 909-918.; Oh et al., pages 919-923., and Byon et al., pages 852-856.

Anti-T-cell globulin (ATG) mediates antitumor activity toward a variety of hematologic malignancies.
See Westphal et al., pages 8756-88

Understanding stem cell heterogeneity in disease.
See Prick et al., pages 841-851.

MSC-derived osteoblasts, a new source of feeder cells for the expansion of HSPC with enhanced thrombopoietic activity.
See Dumont et al., pages 741-752.

Bone marrow Th2 cells promote erythropoiesis at high altitude.
See Li et al., pages 804-815

CD45 regulatory elements facilitate efficient lentiviral traccking of transplanted cells.
See Duong et al., pages 761-772.

Induced pluripotent stem cells from myelofibrosis patients-a novel source of research material.
See Hosoi et al., pages 816-825.

Read more on website.

Member Corner

Congratulations to ISEH Members

Simon Méndez-Ferrer for his manuscript "Neuropathy of haematopoietic stem cell niche is essential for myeloproliferative neoplasms", published in Nature,. 2014 Aug 7;512(7512):78-81.

Toshio Suda, Albert D. Kim and David Traver for their paper "Jam1a-Jam2a interactions regulate haematopoietic stem cell fate through Notch signalling", published in Nature,. 2014 Aug 21;512(7514):319-23.

Grant Challen and Peggy Goodell for the publication of their paper "Dnmt3a and dnmt3b have overlapping and distinct functions in hematopoietic stem cells" in Cell Stem Cell. 2014 Sep 4;15(3):350-64.

Gordon Keller for his paper "Generation of the epicardial lineage from human pluripotent stem cells" published in Nat Biotechnol. 2014 Oct;32(10):1026-35.

.Read more on website.

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