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June 2010 Issue
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Connections in Hematology & Stem Cells is supported by a grant from 

In the June 2010 issue
Meeting Update– AUD$84,000 awarded in travel grants
Early-bird registration extended to 11 June
Late-breaking abstract submission opens 24 June
Speakers offer "great reads” on meeting topics
Award winning Lemischka and Gottgens to speak in Melbourne
News from the Field – ISEH members impact Lund conference
Young Investigators – career advice here!
Member Profile – Gerald de Haan’s focus on the biology of aging

Annual Scientific Meeting Update

AUD$84,000 ISEH Travel Grants Awarded to Date

ISEH has awarded AUD$84,000 to help over 70 scientists travel to Melbourne to present at the ISEH 2010 Annual Scientific Meeting, 15-18 September.

"This significant investment commitment to provide travel grants to the highest ranked oral and poster presenters is an encouragement for scientists, including 40 or so young investigators, to present the latest research in the field in ISEH scientific meetings,” explains Kevin Baliozian, executive director.

More than 200 abstracts were accepted for Melbourne with 78 oral and 128 poster presentations planned. This includes the work from 45 young investigators. "ISEH has a mission to help develop the young scientific minds that are emerging in the field of hematology and stem cells," Baliozian concludes.

Discounts Still Available

You still have a few days to obtain registration discounts for the ISEH 2010 Annual Scientific Meeting, 15-18 September, at the Melbourne Convention & Exhibition Centre in Melbourne, Australia. Members who register before 11 June will save AUD$150!

The Scientific Organizing Committee invites you to watch www.iseh.org for details on the impressive program of original, unpublished, and significant research advances in hematology and stem cell biology.

"Meeting attendees will find great value in this year’s presentations,” states Toshio Suda, MD, ISEH president and member of the Scientific Organizing Committee. "From HSC biology to immunotherapy to microRNAs to drug development, there are breaking discoveries that will be unveiled in front of our prestigious audience. In addition to the information presented from the podium, attendees year after year site discussion with other attendees a popular reason they are sure to attend ISEH.”

Register today!

Submit Late-Breaking Abstracts (24 June to 2 July)

The Annual Scientific Committee has announced that abstracts for late-breaking topics will be accepted 24 June through 2 July. During this time, submit your latest work through the ISEH website.

Good news! Travel grant applications also will be accepted during this time.

What’s Hot?

Click here to view the last article in this e-newsletter that identifies key scientific papers to be read in preparation for the outstanding Melbourne event.


Society News...

Lemischka and Gottgens Win Prestigeous ISEH Awards

ISEH is pleased to announce Ihor Lemischka, PhD, The Mount Sinai Medical Center, and Bertie Gottgens, DPhil, University of Cambridge, as 2010 winners of the Metcalf and McCulloch and Till awards, respectively. Lemischka and Gottgens will present highlights of their award-winning research at the 2010 ISEH Annual Scientific Meeting, 15-18 September in Melbourne, Australia. These scientists also will be profiled in the August issue of Connections in Hematology & Stem Cells where you can learn more about their award-winning work.

The Metcalf Award honors Professor Donald Metcalf, whose pioneering research revealed the control of blood cell formation and the role of hematopoietic cytokines. In the 1960s he developed techniques to culture blood cells, which led to the discovery of colony-stimulating factors (CSFs), which are responsible for resistance to infection. This award, given in his honor, recognizes distinguished scientists in the field of hematology and stem cell biology.

The McCulloch and Till Award honors Professors Ernest McCulloch and James Till, who, together, created the first quantitative, clonal method to identify stem cells and used this technique for pioneering studies on stem cells. McCulloch’s experience in hematology combined with Till's experience in biophysics yielded a novel and productive combination of skills and interests. This award, given in their honor recognizes junior scientists in the field of hematology and stem cell biology.

Members are nominated by their peers for these prestigious awards. Dr. Metcalf will personally present the awards in Melbourne.

Are Your Dues Paid?

To take advantage of all that ISEH has to offer, be sure your 2010 membership dues are paid. If you have any questions regarding your membership status, contact us at membership@iseh.org. If your 2010 membership is outstanding, renew today.


News from the Field...

Hematopoiesis Health and Disease Conference Features ISEH Members

by Keith Humphries, MD, PhD
The BC Cancer Agency Research (Vancouver)

Lund University - SwedenSeveral ISEH members were involved in The Marcus Wallenberg Foundation Conference on Hematopoiesis in Health and Disease held in Lund, Sweden, 15-17 May, 2010. The intense three-day conference featured international leaders in the field addressing the most recent advances related to hematopoiesis and leukemic haematopoietic stem cells.

Session talks on developmental hematopoiesis, erythropoiesis, fate options/self-renewal, leukemia, and translational stem cell biology attested to the still fast pace of discovery in these areas of longstanding interest. A few highlights:

  • David Traver (San Diego) and Timm Schroeder (Munich) described their remarkable work using high-content imaging approaches for lineage tracking that, among other things, are providing answers to questions long asked in the field concerning the early origins of hematopoiesis from hemogenic endothelium.
  • Jonas Larsson (Lund) gave an update on the development of shRNA-based forward genetic screens directly in primary human CD34+ cells to identify candidate stem cell regulators.
  • Gerald de Haan (Groningen) described the powerful application of HSC "bar coding” to track and gain insights into HSC hierarchy and behavior.
  • Tony Green (Cambridge) had us thinking hard about the likely complex clonal origin and evolution of AML emerging from myeloproliferative neoplasms.

Niche, stem cell genomics/epigenetics, and hematopoietic reprogramming and iPS cells sessions offered a glimpse into exciting emerging areas in our field.

  • David Scadden (Boston) presented new evidence that the marrow stroma can play a key role in leukemic transformation creating an almost symbiotic relationship between niche and the leukemic clone.
  • Toshio Suda (Tokyo), Susie Nilsson (Melbourne), and Hiro Nakauchi (Tokyo) dug even further into the nature of the hypoxic niche, the properties of the niche, and provocative new evidence of a neural role in the niche.
  • Scott Armstrong (Boston) provided an update on how detailed expression analysis and epigenetic profiling can yield deep insights into the nature of the cell of origin of leukemia and new therapeutic targets.
  • Bertie Gottgens (Cambridge) presented a tour de force analysis of some 10 transcription factors downstream of SCL from which is emerging a detailed picture of combinatorial transcriptional control of early hematopoiesis.
This brief summary provides just a taste of the meeting content. Hopefully, it will stimulate you to attend the ISEH meeting in Melbourne, where many of these topics will again be highlighted.


Young Investigators - Career Advice Available...

Young investigators attending the Annual Scientific Meeting, 15-18 September, can obtain help navigating their careers during the Career Panel Discussion: Academia, Industry, and Translational Research, 18 September, from 7-8 am.

Merv Yoder, MD, C. Glenn Begley, Ph.D., and Doug Hilton, Ph.D., offer stories of their personal progression from collegiate studies to their current roles at Indiana University, Amgen, and Walter and Eliza Hall Institute respectively.

"As young investigators make choices, they appreciate hearing about what other people have done,” Yoder explains. "We try to give them practical information covering a wide range of opportunities in this branch of science. It’s all about the journey they will take.”

Yoder states that while there are many differences today, discussion of the various facilitating events and major roadblocks of the panelists’ career development can enlighten and encourage young scientists. He admits that some may have trouble relating to their early work as it often involved creating the tools to which young scientists now have ready access.

"Personally, I had to move from lab to lab to garner enough ‘mini-experiences’ to accumulate sufficient skills to launch out on my own,” he says. "Today, there are core programs and kits readily available for researchers. PCR? Early in my career, that involved a stopwatch, tubes, waterbaths and lots and lots of time.

From the young investigators ISEH Connections contacted, it is clear that they crave all information these experienced scientists can offer.

Teresa Venezia Bowman, research fellow at Children’s Hospital Boston, said she would like to know "one piece of advice each of them was given when they were at a critical point in their career that helped them make a decision about how to proceed. Additionally, it would be interesting to get their perspective on how the interconnections of academia and industry have changed during their careers.”

"I would like Drs. Yoder, Begley and Hilton to tell us how they have achieved extramural funding,” stated Shannon McKinney-Freeman, instructor in the Division of Hematology/Oncology at Children’s Hospital Boston. "Also, what did they learn about starting up a new lab – what did they do wrong, what did they do right?

Yi Shen from Commonwealth Science and Industrial Research Organization (CSIRO) is quite interested in the experienced scientists help with research funding and publishing. "How do you deal with rejection of manuscripts and grant requests where you think the experiments were well planned and executed, the data contributes to scientific knowledge and the document was well written?

Be sure to attend this important event at Annual Scientific Meeting in Melbourne.


Member Profile...

ISEH, comprised of industry leaders in hematology, immunology, stem cell research, and cell and gene therapy, connects members worldwide for the opportunity to advance scientific knowledge. Each issue of Connections in Hematology & Stem Cells will introduce you to a few of those members. This issue, meet Gerald de Haan.

Gerald de Haan, PhD
ISEH Vice President

Gerald de HaanDr. Gerald de Haan is scientific director for ERIBA (European Institute on the Biology of Aging) and professor in the Department of Stem Cell Biology at the University Medical Center Groningen in the Netherlands. As ISEH vice president, he is poised to succeed Dr. David Scadden as president in the 2011-2012 term.

Dr. de Haan became enthralled with hematology in his undergraduate years at the University of Groningen in the Netherlands in the late 1980s.

"As an undergraduate biology student, I spent time in Cameroon to study various aspects of malaria immunology,” he recounts. "Ever since then, I have been fascinated by blood biology. When I was offered a PhD position to work on red blood cell kinetics, this seemed like a very logical choice. I have not regretted this decision a single day.”

The University of Groningen and the University Medical Center Groningen decided several years ago to focus their research, education, and care activities on healthy aging. An important component of the strategic plan was to develop a strong research institute, focusing on the biology of aging, on the university premises – ERIBA.

ERIBA research investigators are concerned with molecular mechanisms that are likely to contribute to cellular and organismal aging. These may range from chromosome biology (telomeres, DNA repair, sister chromatid differentiation and separation), regenerative medicine (self-renewal, reprogramming, cell fate decisions), protein folding (translation, aggregation, protein modifications, chaperones), energy metabolism (metabolomics, nutrition, oxygen radicals, mitochondria), immunity (immunesenescence, memory, clonality) to trancriptional regulation (histone and DNA modifications, nuclear transport).

The challenges – and the opportunities – of developing ERIBA are many.

"It is challenging to find the proper balance between staying involved in day-to-day activities in the lab and spending time to make sure we secure enough funds to keep the lab going,” Dr. de Haan shares. "These latter activities obviously include grant writing and travelling. Also, it is not trivial to find the best people for the various projects that we are involved in. We try to recruit our PhD students from those that spend a rotation on our lab, and therefore we need to do our best to attract good students.”

ISEH is an important part of Dr. de Haan’s career development.

"My first ISEH meeting was 1992 in Providence, R.I.,” he explains. "It was great to meet all those people whose papers I had read. This was the time when labs were chasing crucial growth factors and their receptors. It was a highly stimulating experience at a time halfway through my PhD project. It was also the occasion where I first met my later postdoctoral supervisor, Gary Van Zant.

Truly devoted to his science, Dr. de Haan acknowledges that it is important to spend time away from the lab and its responsibilities.

"I spend most of my non-science hours with my family, which means that many of my weekends are filled with watching field hockey games,” Dr. de Haan shares. "I need those family moments to stay fresh, and would find it very difficult to perform well in science without.” 


More Annual Scientific Meeting Information...

Good "Reads” to Prepare for Melbourne

Several session chairs have provided the information below to maximize the value you will receive from the Annual Scientific Meeting. You may wish to review the suggested articles in preparation for session attendance.

Thursday, 16 September

Session 4: Developmental Hemopoiesis (in memory of Greg Johnson)
Chairs: Merv Yoder & Nick Nicola
Speakers: Chung Li (Taiwan); Georges Lacaud (UK); Elaine Dzierzak (Holland); Paul Gadue (USA)

Dzierzak E and Speck NA.
Of lineage and legacy – the development of mammalian hematopoietic stem cells.
Nature Immunol 9:129-136, 2008.

Lancrin et al.
Blood cell generation from the hemangioblast.
J Mol Med 88:167-172, 2010.

Olsen et al.
Designer blood: creating hematopoietic lineages from embryonic stem cells.
Blood 107: 1265-1275, 2006.

Session 5: Animal Models of Leukemiagenesis
Chairs: Gerald de Haan & Toshio Kitamura
Speakers: Richard Lock (Aust); Graham Lieschke (Aust); Mineo Kurokawa (Japan)
Plus 1 abstract presentation

Jin L, Lee EM, Ramshaw HS, Busfield SJ, Peoppl AG, Wilkinson L, Guthridge MA, Thomas D, Barry EF, Boyd A, Gearing DP, Vairo G, Lopez AF, Dick JE, Lock RB.
Monoclonal antibody-mediated targeting of CD123, IL-3 receptor alpha chain, eliminates human acute myeloid leukemic stem cells.
Cell Stem Cell. 2009 Jul 2;5(1):31-42. PMID: 19570512 [PubMed - indexed for MEDLINE]

Carradice D, Lieschke GJ.
Zebrafish in hematology: sushi or science?
Blood. 2008 Apr 1;111(7):3331-42. Epub 2008 Jan 8. Review. PMID: 18182572 [PubMed - indexed for MEDLINE]

Lieschke GJ, Currie PD.
Animal models of human disease: zebrafish swim into view.
Nat Rev Genet. 2007 May;8(5):353-67. Review. PMID: 17440532 [PubMed - indexed for MEDLINE]

Goyama S, Yamamoto G, Shimabe M, Sato T, Ichikawa M, Ogawa S, Chiba S, Kurokawa M.
Evi-1 is a critical regulator for hematopoietic stem cells and transformed leukemic cells.
Cell Stem Cell. 2008 Aug 7;3(2):207-20. PMID: 18682242 [PubMed - indexed for MEDLINE]

Friday, 17 September

Session 9: HSC Mobilisation
Chair: Linda Bendall & Chung Li
Speakers: Tsvee Lapidot (Israel); Jean-Pierre Levesque (Aust)
Plus 3 abstract presentations

Papayannopoulou T, Scadden DT.
Stem-cell ecology and stem cells in motion.
Blood. 2008 Apr 15;111(8):3923-30.

Winkler IG, Barbier V, Wadley R, Zannettino A, Williams S, Levesque JP.
Positioning of bone marrow hematopoietic and stromal cells relative to blood flow in vivo: Serially reconstituting hematopoietic stem cells reside in distinct non-perfused niches.
Blood, 14 April 2010, Vol. 0, No. 2010, pp. 200907233.

Vagima Y, Avigdor A, Goichberg P, Shivtiel S, Tesio M, Kalinkovich A, Golan K, Dar A, Kollet O, Petit I, Perl O, Rosenthal E, Resnick I, Hardan I, Gellman YN, Naor D, Nagler A, Lapidot T.
MT1-MMP and RECK are involved in human CD34+ progenitor cell retention, egress, and mobilization.
J Clin Invest. 2009 Mar;119(3):492-503

Session 11: HSC Homing/Trafficking
Chair: Tsvee Lapidot & JP Levesque
Speakers: Steffen Massberg (USA); Amy Wagers (USA)
Plus 3 abstract presentations

Papayannopoulou T, Scadden DT.
Stem-cell ecology and stem cells in motion.
Blood. 2008 Apr 15;111(8):3923-30.
http://bloodjournal.hematologylibrary.org/cgi/content/abstract/111/8/3923?

Spiegel A, Kalinkovich A, Shivtiel S, Kollet O, Lapidot T.
Stem cell regulation via dynamic interactions of the nervous and immune systems with the microenvironment.
Cell Stem Cell. 2008 Nov 6;3(5):484-92.

Saturday, 18 September

Concurrent Oral Presentation 5: MicroRNAs in Hemopoiesis
Chairs: Thalia Papayannopoulou & Robert Oostendorp
Speakers: TBD
Plus 6 abstract presentations

Kluiver J, Kroesen BJ, Poppema S, van den Berg A.
The role of microRNAs in normal hematopoiesis and hematopoietic malignancies.
Leukemia. 2006 Nov;20(11):1931-6. Epub 2006 Sep 14. (Review). PMID: 16990772

Raaijmakers MH, Mukherjee S, Guo S, Zhang S, Kobayashi T, Schoonmaker JA, Ebert BL, Al-Shahrour F, Hasserjian RP, Scadden EO, Aung Z, Matza M, Merkenschlager M, Lin C, Rommens JM, Scadden DT.
Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia.
Nature. 2010 Apr 8;464(7290):852-7. Epub 2010 Mar 21. PMID: 20305640

Han YC, Park CY, Bhagat G, Zhang J, Wang Y, Fan JB, Liu M, Zou Y, Weissman IL, Gu H.
microRNA-29a induces aberrant self-renewal capacity in hematopoietic progenitors, biased myeloid development, and acute myeloid leukemia.
J Exp Med. 2010 Mar 15;207(3):475-89. Epub 2010 Mar 8. PMID: 20212066 

Concurrent Oral Presentation 6: HSC Microenvironment
Chairs: Kateri Moore & Shannon McKinney-Freeman
Speakers: TBC
Plus 6 abstract presentations

Iwasaki H, Suda T.
Cancer stem cells and their niche.
Cancer Sci. 2009 Jul;100(7):1166-72.

Lane SW, Scadden DT, Gilliland DG.
The leukemic stem cell niche: current concepts and therapeutic opportunities.
Blood. 2009 Aug 6;114(6):1150-7.

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