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Connections December 2014
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December 2014

About ISEH

The mission of ISEH is to promote the scientific knowledge and clinical application of basic hematology, immunology, stem cell research, cell and gene therapy, and all related aspects through research, publications, discussion, support of new investigators and organization of scientific meetings.

Table of Contents

President's Message
New Investigator Digest
News from the Field
Don't Miss Sessions
Member Profile
Society News
Experimental Hematology
Member Corner

Donate now to the ISEH New (Junior) Investigator Travel Grant fund


 

Save the Date for the 44th Annual Scientific Meeting
17-19 September 2015
Kyoto, Japan

President's Message: Of members and impact factors  

Members are the heart of our Society.  Despite the high level of enthusiasm for ISEH’s Annual Meeting and the recognition that ISEH brings a unique educational experience for new and established investigators, the membership of ISEH has dwindled over the past two decades (see Figure 1). The strategic plan calls for increasing the membership from ~600 to ~900 members by 2017. 

Our Past President, Peggy Goodell, put together a task force headed by Hanna Mikkola and David Traver to strengthen the membership.  This effort will be sustained this year by increasing the society's presence in emerging markets. A broader membership would strengthen the foundation of ISEH, increase networking opportunities, and give us a greater pool of volunteers to serve as society officers or in special committees.  It would also grow our revenues such that we can deliver our programs without relying on extensive fundraising activities.

How can you help? Many of us joined ISEH because of a referral from a mentor or colleague; word of mouth is still our most effective recruiting tool. So as a member, you are best positioned to help us recruit new members. You know that ISEH is a unique forum that promotes the interest of experimental hematologist most effectively. The scientific level and personal interactions that most members find so satisfying at ISEH meetings are not replicated at larger conferences. We all know bright students or colleagues who aren’t yet ISEH members, so please help both ISEH and that student or colleague by explaining the benefits of joining our society (reduced registration fees for the Annual Meeting, free access to ISEH Connections and webinars, no page or submission fees to Experimental Hematology, to name a few.

Another disconcerting trend has been the progressive fall in the impact factor of Experimental Hematology.  Keith Humphries, Editor-in-Chief, and his editorial team (http://www.exphem.org/content/edboard) have made sustained efforts to reverse the course by publishing excellent papers as well as a collection of reviews for the journal's 40th anniversary and a special issue - Genomics and Model Organisms: New Horizons for Experimental Hematology. Due to the success of this initiative (6300 downloads since publication), the editors are moving forward with preparations for another special issue that will be published just before the 2015 ISEH meeting in Kyoto. Atsushi Iwama has kindly agreed to serve as guest editor for next year’s special issue, which will focus on hematologic malignancies with two major topics: Advances in Understanding the Origin and Pathogenesis of Hematologic Malignancies and New Therapeutic Approaches for Hematologic Malignancies.

Additionally, the journal will publish another collection of reviews on subjects that stemmed from "citation classics" previously published in the journal. Anna Rita Migliaccio will be the guest editor for this series that will extend into 2016. If you have a review topic that you would like to see included in this series or you want to contribute a review, please contact the journal's Scientific Editor at exphem@iseh.org. Experimental Hematology has been the Society's flagship journal for over 40 years and is a main source of income for the society. Please continue to support the journal as it is in all members' interests to make it impactful and keep it healthy and vibrant. 

With this opportunity I wish you a very happy, prosperous and healthy New Year.

Sincerely,

Paul Frenette
ISEH President  

New Investigator Digest

Online Education: Can it help us become better scientists?

Eugenia (Kena) Flores-Figueroa1 and Peter van Galen2

1) Oncological Research Unit at the Mexican Institute of Social Health, Mexico City, Mexico 2) Massachusetts General Hospital and Broad Institute of MIT and Harvard, USA.

In 1990, before the commercial use of the World Wide Web existed, Steve Jobs referred to the computer as “the bicycle for our minds” to explain how he envisioned the use of computers as “the most remarkable tool that we’ve ever come up with”. He explained that he invented his analogy while reading an article in Scientific American. The article was about an interspecies comparison on the efficiency of locomotion in which man was at the third lowest place. But a man riding a bicycle was at the top of the list, even above the condor (which was the most efficient species). Jobs’ vision is now a reality, personal computers are our most valuable tool in modern life- they have transformed our lives. We use them daily in our jobs, for entertainment, and most of all, as a portal to retrieve information through the internet. The paradox is that we are now facing a challenge in the quality of information we find online.

Eighty seven percent of internet users in the United States recognized that the Web helps them learn new things: they feel more informed about products and services to buy, news, and popular culture. Academic information was not one of the top topics on that list. Despite accelerated growth of worldwide internet usage in the past 14 years (over 700%, ref. 1), online education has been growing slowly, and it has been facing faculty resistance. According to the Babson Survey (2013), faculty acceptance of online courses in 2012 was at the same percentage (around 30%) as in 2004, and only 6% above the first poll in 2002 (2). We think online courses are a great way to increase accessibility of education and we will explain how they can be used to expand your knowledge and skillset as a scientist. Read more on website.

News From the Field

bluebird bio Announces First Patient with Sickle Cell Disease Transplanted with LentiGlobin Gene Therapy

AgonOx’s OX40 Platform Being Utilized in MedImmune’s Phase I OX40 Agonist Study

Theravectys Provides Update On Its Phase I/Ii Lentiviral Vector-Based Therapeutic Vaccine Trial

Bergenbio Receives Orphan-Drug Designation From FDA For BGB324 In The Treatment Of Acute Myeloid Leukaemia

Sunesis Announces Results from Pivotal Phase III VALOR Trial of Vosaroxin and Cytarabine in Patients with First Relapsed or Refractory Acute Myeloid Leukemia

IMBRUVICA® (ibrutinib) Now Approved in Europe for Treatment of Two Blood Cancers

BioLineRx Files Protocol Amendment to Phase II Study for AML Treatment based on Encouraging Efficacy and Strong Safety Profile

Cell Source's Megadose Drug Combination Receives Regulatory Approval in Italy to Commence Human Clinical Trials

Don't Miss Sessions

Keystone Symposia Epigenetics and Cancer
Keystone Resort, Keystone, Colorado, USA 
25-30 January 2015

The meeting brings together scientists who are interested in understanding the connections between basic epigenetic pathways and the process of cancer. One aspect of the meeting will highlight the mechanisms by which epigenetic pathways control various biological processes. A second aspect will revolve around the connections between epigenetic pathways and cancer.

Tumor Immunology: Multidisciplinary Science Driving Combination Therapy
Fairmont Banff Springs, Banff, Alberta, Canada
8-13 February 2015

This conference brings together experts from academia and industry who have pioneered the field of cancer immunotherapy, and will showcase the integration of this increasingly complicated knowledge into rapid translation into clinical applications.

Gordon Research Conferences - Stem Cells & Cancer
Ventura, CA, USA 15-20 February 2015

The Fifth Gordon Conference on Stems Cells and Cancer will focus on understanding how cancer stem cells behave and interact with their niche. Topics that will be explored at the meeting will be to examine diversity of cancer stem cells as they regulate metastasis, an understanding of normal stem cell biology including epigenetic regulation, and understanding of aging and cancer, cancer stem cell biology including clonal evolution. 

Genetic Engineering of Mammalian Stem Cells
Wellcome Trust Genome Campus
Hinxton, Cambridge, UK, 16-28 February 2015

This laboratory-based training course will provide a comprehensive overview and practical laboratory experience of the genetic manipulation of mammalian stem cells. Focusing on mouse ES and human iPS cells, genome informatics, recombineering, CRISPR designer nucleases, transposon technology and gene targeting will be covered in interactive demonstrations, discussions and lectures by international experts. 

CellTech India 2015
Bangalore, India, 2-3 March 2015

This conference will focus on the analysis of cells and its diverse applications in bio-molecular and chemical biology research techniques and will also cover stem cell based therapies for treating cancers along with role of circulating tumor cells as predictive Biomarkers. 

Read more on website.

Member Profile

Meet Dr. Daniel Lipka - 2014 Winner of the ISEH New Investigator Award

Dr. Daniel Lipka, MD, is the 2014 winner of the ISEH New Investigator Award, given to the best presentation by a post-doctoral fellow. He is a postdoc in the laboratory of Professor Christoph Plass, German Cancer Research Center (DKFZ), Heidelberg, Germany. Dr. Lipka is board certified for internal medicine, hematology and oncology and has been working in the field of hematology and stem cell for 9 years as a clinician and 3 years in basic research. He joined ISEH a year ago.

Dr. Lipka took the time to participate in a Q&A session with Connections. Below he discusses how he transitioned from a clinician to a basic scientist, exciting developments in his research, as well as his future goals as an independent scientist.

Can you tell us about your post-graduate education, generally?

I studied medicine at the Universities of Heidelberg (Germany) and Madrid (Spain). Afterwards, I completed my training in Internal Medicine at the University Medical Centers of Ulm and Mainz in Germany and then moved to the University Medical Center in Magdeburg to specialize in Hematology/Oncology in the program lead by Prof. Thomas Fischer. In 2011, I then chose to leave clinical practice in order to pursue my growing interest in medical research and took up a position within the Division of Epigenomics and Cancer Risk Factors at the German Cancer Research Center (DKFZ) under the guidance of Professor Christoph Plass. Since then, my scientific research focuses on how the epigenome regulates the biology of both normal and malignant hematopoiesis.

Who has most influenced you to become a scientist, and how did they influence you? 

My clinical mentor Thomas Fischer is a clinician scientist who dedicated his entire career to combine translational research with academic clinical medicine. During my entire clinical training, he supported and enforced my interest in hematologic research, which ultimately led to the decision to move into basic hematologic research. 

Read more on website.

Society News

It's ISEH Membership Renewal season—Renew today!

To renew your membership log into your account, and pay your dues by clicking on "Renew Your Membership Now." If you are not automatically directed to this page upon your login, click here to access the renewal page. Need help with your login information? Email info@iseh.org for assistance.

Remember, Active members can now renew for two-years and then cross "renew ISEH membership” off your to-do list for next year!

Do you know 5+ scientists who should be members of ISEH and have been waiting for the right moment? The time has come, ISEH is offering group membership rates for groups of five or more new members from the same facility, email info@iseh.org for more details.

Save the Date for the 44th Annual Scientific Meeting

Kyoto International Conference Center, Kyoto, Japan, 17-19 September 2015

As you look forward to welcoming the new year, remember to include the ISEH 44th Annual Scientific Meeting on your 2015 calendar.

Considering submitting an abstract for 2015? The ISEH Call for Abstracts will open on February 16, 2015 – it will be February before you know it!

Experimental Hematology

Inside Experimental Hematology: November and December 2014

An ALL xenograft model that simulates the process of clonal selection of chemoresistant clones. See Nowak et al., pages 32-93.

Mixed chimerism in C3a-deficient mice. See Baśkiewicz-Hałasa et al., pages 14-22.

Donor chimerism in CD25+-activated leukocytes as a predictor of GvHD after stem cell transplantation. See Martínez-Laperche et al., pages 4-13.

Murine CALM-AF10 cells are sensitive to iron depletion in vitro but not in vivo. See Heath et al., pages 1022-1030.

The mixed-lineage leukemia gene (MLL1), a paradigm to understand leukemogenesis through aberrant epigenetic gene regulation. See Li et al., pages 995-1012.

STAT3 and PRL-3: two prominent oncogenic molecules are now connected. See Zhou et al., pages 1041-1052.

Read more on website.

Member Corner

Congratulations to ISEH members for the recent publication of their ground-breaking research

Simon Joydeep Ghosh, Kevin D. Bunting, Yan Liu, Rebecca J. Chan, Reuben Kapur: Regulation of Stat5 by FAK and PAK1 in Oncogenic FLT3- and KIT-Driven Leukemogenesis. Cell Reports, 2014 Nov 20;9(4):1333-48.

Denis-Claude Roy, Keith Humphries, Connie Eaves and Guy Sauvageau: Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal. Science. 2014 Sep 19;345(6203):1509-12.

Philip A. Beer, Gudmundur L. Norddahl , Ping Xiang, Tobias Berg, Connie J. Eaves and Keith Humphries: Modeling de novo leukemogenesis from human cord blood with MN1 and NUP98HOXD13. Blood. 2014 Oct 22. [Epub ahead of print]

Linheng Li: Megakaryocytes maintain homeostatic quiescence and promote post-injury regeneration of hematopoietic stem cells. Nat Med. 2014 Nov;20(11):1321-6.

Bruns Ingmar, Lucas Daniel, Ahmed Jalal, Kunisaki Yuya and Paul Frenette: Megakaryocytes regulate hematopoietic stem cell quiescence through CXCL4 secretion. Nat Med. 2014 Nov;20(11):1315-20.

David Traver: FGF signalling restricts haematopoietic stem cell specification via modulation of the BMP pathway. Nat Commun. 2014 Nov 27;5:5588.

Albert Kim, David Stachura, Clements Wilson K and David Traver: FGF signalling specifies haematopoietic stem cells through its regulation of somitic Notch signalling. Nat Commun. 2014 Nov 27;5:5583.

David Stachura, Albert Kim and David Traver: Proinflammatory signaling regulates hematopoietic stem cell emergence. Cell. 2014 Nov 20;159(5):1070-85.

Albert Kim, Wilson K.Clements, Daniel L Stachura and David Traver: Discrete Notch signaling requirements in the specification of hematopoietic stem cells. EMBO J. 2014 Oct 16;33(20):2363-73.

David Stachura and David Traver: Loss of IP3R-dependent Ca2+ signalling in thymocytes leads to aberrant development and acute lymphoblastic leukemia. Nat Commun. 2014 Sep 12;5:481.

Vincenzo Calvanese, Gay Crooks, Mattias Magnusson and Hanna Mikkola: GPI-80 Defines Self-Renewal Ability in Hematopoietic Stem Cells during Human Development. Cell Stem Cell, 2014 November 13, 2014, ahead of print

Ravi Bhatia: SIRT1 activation by a c-MYC oncogenic network promotes the maintenance and drug resistance of human FLT3-ITD acute Myeloid Leukemia stem cells. Cell Stem Cell. 2014 Oct 2;15(4):431-46.

Read more on website

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