Boston Children's Hospital/Dana-Farber Cancer Institute,
Harvard Medical School
Location: Boston, USA Position: Postdoctoral Training Position
Topic: Gene regulation in normal and malignant hematopoiesis; leukemia predisposition syndromes:
The Cantor Laboratory at Boston Children’s Hospital/Harvard Medical School is currently accepting applications for entry-level post-doctoral training positions. The lab focuses on further elucidating the basic transcriptional and epigenetic mechanisms that underlie normal hematopoietic stem cell fate decisions and terminal maturation. We also seek to understand how the dysregulation of these processes contributes to human leukemogenesis and other blood disorders, and to translate these findings into novel therapeutic approaches. One current focus is on leukemia predisposition syndromes and clonal hematopoiesis. We utilize a variety of approaches including biochemical, genomic, genome editing, mouse modeling, human primary cell systems, iPS cell systems, and human genetics to study these questions.
Candidates should have recently (within ~1 year) obtained a PhD or an MD/PhD degree in the fields of Molecular Biology, Cellular Biology, Biochemistry, Development, or Genetics. The candidate should have evidence of prior productive scientific work in the form of publications in peer-reviewed journals. Prior experience in the study of gene regulation, hematopoiesis, DNA damage response/repair, genotoxic stress, and/or use of mouse models is preferred.
U.S. citizenship or Permanent Resident status (i.e., “Green Card” holders) is not necessary, but is preferred.
Location: Germany Position: Postdoctoral or Group Leader Position (based on the applicant`s qualification) Topic: Mechanisms Operating During Hematopoiesis and Leukemogenesis
A POSTDOCTORAL or GROUP LEADER position (based on the applicant`s qualification) is open in the Division of Translation Oncology, Department of Hematology, Oncology and Immunology, University Hospital Tuebingen, University of Tuebingen, Germany starting as soon as possible. The Division is led by Prof. Julia Skokowa MD, PhD in a tight collaboration with Prof. Karl Welte MD.
The project is focused on the investigations of the cellular and molecular mechanisms operating during myeloid differentiation and leukemogenic transformation of hematopoietic stem cells. Study includes cell- and molecular biology investigations on human and mouse primary hematopoietic cells, cells of patients with congenital neutropenia, de novo AML and CML blasts, patients-derived iPSCs as well as mouse and zebrafish models. Main technologies of the lab are CRISPR/Cas9-based gene modifications of primary cells and cell lines, RNA-Seq, ChIP-Seq, NGS incl. Exome- and Deep-Seq., protein biochemistry. Long tirm goal of the project is to define novel therapeutic strategies for hematological malignancies and novel tools for high-scale generation of blood cells in vitro and in vivo.
The group offers an active English-speaking international environment with the opportunity to carry out high level translational research in an exciting and rapidly moving field. The required up-to-date equipment and methodology (incl. CRISPR/Cas9-based gene modifications of primary cells and cell lines, RNA-Seq, ChIP-Seq, NGS incl. Exome and Deep-Seq. and protein biochemistry) as well as lab and office space in a new research building will be provided. Successful applicants will have the possibility to apply their research skills in a broad collaborative environment in the fields of genetics, cell and molecular biology, biochemical studies of protein deacetylation, iPS cell models, mouse models, and zebrafish models in a tight cooperation with the phisicians from the Department of Hematology, Oncology and Immunology as well as with the Severe Chronic Neutropenia International Registry. We also offer a possibility of the tight collaboration with the Max-Planck Institute (MPI) of Developmenta Biology in Tübingen.
We are seeking a highly motivated applicant with a PhD degree, preferably in Hematology, Oncology or Immunology. Specific proven experience in blood cell biology and molecular biology and/or experience in mouse or zebrafish models of hematopoiesis and leukemogenesis would be of benefit. A strong publication record will be appreciated. Good knowledge of English (oral and written), self-motivation and ability to work independently as well in a group are essential.
The initial contract will be for a three years period, with the opportunity to get a tenure position after internal evaluation. Salary is based on the experience.
Please send your application with a CV, list of publications, short description of research accomplishments and 3 reference letters or the names of 3 references to firstname.lastname@example.org
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