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2015 Annual Meeting Program
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Thursday, 17 September 2015
*last updated 19 September 2015

8:00 - 18:00 Foyer/Entrance Hall  Registration Open
9:00 Room A Welcome and Opening Remarks
9:00 - 10:00 Room A Session 1: Donald Metcalf Lecture
*David Traver, University of California San Diego, USA
Elaine Dzierzak, University of Edinburgh, UK (1001)
The AGM and The Regulations of Hematopoietic Stem Cell Development
10:00 - 10:15 Foyer Break
 10:00 - 20:00 Foyer Exhibit Hall Open 
10:15 - 11:45 Room A Session 2: Hematopoiesis I 
*Patricia Ernst
, University of Colorado Denver, USA
*Markus Manz, Universitäts Spital Zürich, Switzerland
Margaret A. Goodell, Baylor College of Medicine, USA (1002)
DNMT3A and TET2 Cooperate and Compete to Prevent Leukemogenesis
Amy J. Wagers, Harvard University, USA (1003)
Local and systemic regulators of aging phenotypes in mammalian tissues
Atsushi Hirao, Kanazawa University, Japan (1041)
Molecular mechanism linking hematopoietic stem cell aging and leukemogenesis 
11:45 - 13:30 Room A Session 3: Sponsored Lunch Session
*Kinuko Mitani
, Dokkyo Medical University , Japan, sponsored by Janssen Pharmaceutical K.K 
*Shinya Kimura
, Division of Hematology, Respiratory Medicine and Oncology, Saga University Faculty of Medicine, Japan, sponsored by Novartis Pharma K.K.
Daniel G. Tenen, National University of Singapore, Singapore (1005), sponsored by Janssen Pharmaceutical K.K.
Noncoding RNA Regulation of Myeloid Transcription Factors, DNA Methylation, and Leukemia
Irving Weissman, Stanford University, USA (1006), sponsored by Novartis
Normal and Neoplastic Stem Cells
13:30 - 15:00 Room A Session 4: Imaging Workshop
*Fumio Arai, Kyushu University, Japan
Fumio Arai,
Kyushu University, Japan (1007), sponsored by Eisai Co., Ltd. 
Introduction of Hematopoietic stem cell niche
Yuya Kunisaki, Kyushu University, Japan (1008), sponsored by Eisai Co., Ltd. 
The Imaging of the Bone Marrow and Hematopoietic Stem Cells
Charles P. Lin, Harvard University, USA (1009), sponsored by Eisai Co., Ltd. 
Optical Techniques for Characterizing the Bone Marrow Microenvironment
15:00 - 16:30 Room A Session 5: Leukemia I
*Catriona Jamieson
, University of California San Diego, USA 
*Eirini Papapetrou, Icahn School of Medicine at Mount Sinai
Koichi Akashi, Kyushu University, Japan (1010)
TIM-3 and its ligand, galectin-9 constitute an autocrine loop to maintain stem cells in most human myeloid malignancies
Iannis Aifantis, New York University, USA (1011)
Modeling the Function of the Cohesin Complex in Hematopoietic Stem Cell Differentiation and Transformation
Sabine Jurado, Research Institute of Molecular Pathology, Austria (2003) 
Short Talk: Rapid formation of B cell leukemia in mice expressing the Pax5-JAK2 fusion protein
Cedric Tremblay, Monash University, Australia (2004)
Short Talk: Overcoming Quiescence by Targeting P21 (CDKN1A) Sensitizes Pre-Leukemic Stem Cells to Chemotherapy 
15:00 - 17:30 Sakura Poster Set-Up: Odd-numbered Abstracts
16:30 - 18:00 Room A Session 6: HSC Niche - ISEH/JSH Joint Session
*Toshio Suda, Cancer Science Institute, National University of Singapore, Singapore
*Paul Frenette, Albert Einstein School of Medicine, USA
Takashi Nagasawa, Kyoto University, Japan (1012)
The Microenvironmental Niches for Hematopoietic Stem and Progenitor Cells in Bone Marrow
Yoshio Katayama, Kobe University, Japan (1013)
Lympho-hematopoietic Microenvironment Regulated by Inter-organ Communication
Tsvee Lapidot, Weizmann Institute, Israel (1014)
Metabolic Regulation of Hematopoietic Stem Cells by the Bone Marrow Microenvironment
Louise Purton, St. Vincent's Institute, Australia (1015)
Cytotoxic Therapies Cause Irreversible Damage to the Niches for Multipotent Progenitor Cells, Resulting in Impaired Long-term Repopulating Potential of Bone Marrow
18:00 - 20:00 Sakura Poster Viewing and Discussion I
(Odd-numbered posters)
20:00 - 21:30 Garden Welcome Reception
Sponsored by the Local Organizing Committee

20:00 - 21:00 Sakura Poster Take Down: Odd-numbered Abstracts

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Friday, 18 September 2015

8:00 - 17:00 Foyer/Entrance Hall Registration Open
9:00 - 10:30 Room A Session 7: Hematopoiesis II
*Hideo Ema
, Keio University, Japan
*Amy J. Wagers, Harvard University, USA
Timm Schroeder, ETH Zurich, Switzerland (1016)
 Long-term Single Cell Quantification: New Tools for Old Questions
Juan Carlos Zuniga-Pflucker, University of Toronto, Canada (1017)
From Stem Cells to T cells, in Vitro Applications and in Vivo Implications
Marieke Essers, DKFZ/HI-STEM, Germany (2005)
Short Talk: Extracellular matrix protein Matn4 regulates HSC stress response
Ayako Nakamura-Ishizu, National University of Singapore, Singapore (2006)
Short Talk: CLEC-2 signaling is crucial for the production of thrombopoietin in the megakaryocyte niche
9:00 - 10:30 Sakura  Poster Set-Up: Even-numbered Abstracts
10:30 - 10:45 Foyer Break
10:30 - 19:30  Foyer  Exhibit Hall Open
10:45 - 12:30 Room A Session 8: Sponsored Lunch Session
*Toshio Kitamura
, Division of Cellular Therapy / Division of Stem Cell Signaling, Institute of Medical Science, Japan, sponsored by CHUGAI PHARMACEUTICAL CO., LTD.
 *Koichi Akashi, Kyushu University School of Medicine, Japan, sponsored by Bristol-Myers K.K.
David Scadden, Harvard University, USA (1018), sponsored by CHUGAI PHARMACEUTICAL CO., LTD.
Making blood: the organized labor of multiple niches
John E. Dick, University of Toronto, Canada (1019), sponsored by Bristol-Myers K.K.
Stem Cell in Cancer: Do They Matter?
12:30 - 14:00 Room A Session 9: New Investigator Career Panel- How to Prepare for a Job Interview
*Eugenia Flores-Figueroa, Oncological Research Unit at the Mexican Institute of Social Health, Mexico 
*Isabel Beerman, Boston Children’s Hospital/Harvard Medical School, USA
Margaret A. Goodell, Baylor College of Medicine, USA
Takashi Nagasawa, Kyoto University, Japan
Harmut Geiger, Cincinnati Children's Hospital Medical Center, USA
Daniel Lucas, University of Michigan, USA

14:00 - 15:30 Room A Session 10: Presidential Symposium
*Paul Frenette
, Albert Einstein School of Medicine, USA
Peter Carmeliet, Vlaams Instituut voor Biotechnologie, Belgium (1020)
Angiogenesis Revisited: Endothelial Cell Metabolism as a Target?
Hiromitsu Nakauchi, Stanford University, USA (1021)
Dietary Created Niche for Non-myeloablative Hematopoietic Stem Cell Transplantation
Shahin Rafii, Cornell University, USA (1022)
Pxecutive functions of the vascular niche in hematopoietic specification maintenance and regeneration
15:30 - 16:00 Foyer Break
16:00 - 17:30 Room B-1 Session 11A: Developmental Hematopoiesis I
*James Palis,
University of Rochester Medical Center, USA
*Wilson Clements,
St. Jude Children's Research Hospital, USA
Utpal Banerjee, University of California Los Angeles, USA (1023)
Local and Systemic Signaling in Maintenance of Hematopoietic Progenitors
Anna Bigas, Institut de Recerca de Hospital del Mar, Spain (1024)
Notch Signal Strength Controls Endothelial to Hematopoietic Transition
Trista North, BIDMC/Harvard Medical School, USA (2007)
Short Talk: Serotonin Regulates HSC Formation via Glucocorticoid Production from the Hypothalamic-Pituitary-Interrenal Axis
Vashe Chandrakanthan, University of New South Wales, Australia (2008)
Short Talk Genetic Fate Mapping of Mesenchymal Stem-Like Cells in the Aorta-Gonad Mesonephros (AGM) and Their Contribution to Developmental Hematopoiesis 
16:00 - 17:30 Room B-2 Session 11B: Cell and Gene Therapy
*Stefan Karlsson,
Lund University, Sweden
*Andrew Elefanty,
Murdoch Children's Research Institute, Australia 
Edward Rebar,
Sangamo BioSciences, Inc., USA (1039)
Genome Editing with Engineered Zinc Finger Nucleases
Ute Koch, Ecole Polytechnique Federale de Lausanne (1040)
Dicer1 Imparts Essential Survival Cues in Notch Driven T-ALL via miR-21 Mediated Tumor Suppressor Pdcd4 Repression
Claudia Waskow, TU Dresden, Germany (2009)
Short Talk: Kit deficiency regulates stable human hematopoietic stem cell engraftment in mice
Elizabeth Ng, MCRI/Monash University, Australia (2010)
Short Talk: HOXA Gene Expression Defines Definitive Fetal Hematopoietic Cells Differentiated from hESCs
17:30 - 19:30 Sakura Poster Viewing and Discussion II
(Even-numbered posters)
19:30 - 20:30 Sakura  Poster Take Down: Even-numbered Abstracts 
19:30 - 21:00 Cocktail Lounge New Investigator Meet the Expert Mixer
(pre-registration required)

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Saturday, 19 September 2015

8:00 - 18:00 Foyer/Entrance Hall  Registration Open
9:00 - 12:00 Foyer  Exhibit Hall Open
9:00 - 10:30 Room B-1 Session 12A: Epigenetics and Genomics
*Margaret A. Goodell
, Baylor College of Medicine, USA
Bertie Göttgens, University of Cambridge, UK (1027)
Defining Stem Cells and Regulatory Networks by Single Cell Profiling
Marnie Blewitt, The Walter and Eliza Hall Institute of Medical Research, Australia (1028)
iHstone H3 Lysine 9 Methylation is Involved Not Only in Maintaining Epigenetic Silencing, but is Essential for Setting up Gene Silencing
Judith Schütte, University of Cambridge, Germany (2011)
Short Talk:  A fully validated blood stem/progenitor cell regulatory network reveals mechanisms of cell state stabilisation
Nina Cabezas-Wallscheid, German Cancer Research Center (DKFZ), Germany (2012)
Short Talk: Identification of Regulatory Networks in HSCs and Their Immediate Progeny via Integrated Proteome, Transcriptome, and DNA Methylome Analysis
9:00 - 10:30 Room B-2 Session 12B: Leukemia II
*Andreas Trumpp, DFFZ/HI-STEM, Germany
*Claudia Lengerke
, University of Basel, Switzerland
Catriona Jamieson, University of California San Diego, USA (1029)
Non-coding RNA Editase Deregulation as a Driver of Leukemia Stem Cell Generation
Eirini Papapetrou, Icahn School of Medicine at Mount Sinai, USA (1030)
Modeling Myeloid Malignancies with Human Induced Pluripotent Stem Cells
Daniel Lipka, German Cancer Research Center (DKFZ), Germany (2013)
Short Talk: Genome-wide DNA methylation profiling reveals two prognostically distinct subgroups of juvenile myelomonocytic leukemia
Takahiro Ito, University of Georgia, USA (2014)
Short Talk:  Post-transcriptional regulation of AML propagation by oncogenic RNA binding proteins

10:30 - 10:45 Foyer Break
10:45 - 12:30 Room A Session 13: Sponsored Lunch Session
*Keiya Ozawa
, The Institute of Medical Science, The University of Tokyo, Japan, sponsored by Kyowa Hakko Kirin Co., Ltd.
*Masahiro Kizaki, Department of Hematology, Saitama Medical Center, Saitama Medical University, Japan, sponsored by Celegene K.K
Alan D'Andrea, Dana-Farber Cancer Institute, USA (1031), sponsored by Kyowa Hakko Kirin Co., Ltd.
Fanconi Anemia and Bone Marrow Failure
Toshio Suda, Cancer Science Institute, National University of Singapore, Singapore (1032)
Hematopoiesis under Stress
Akiko Shimamura, Fred Hutchinson Cancer Research Center (1026)
Genomic Studies of Marrow Failure

12:30 - 13:30 Foyer Informal Networking Break
13:30 - 15:00 Room B-1 Session 14A: Developmental Hematopoiesis II
*Hanna Mikkola
, University of California Los Angeles, USA
*Trista North, BIDMC/Harvard Medical School, USA
Catherine Robin, Hubrecht Institute, The Netherlands (1033)
Hematopoietic Stem Cell Production and Regulation in the Embryo Aorta
Georges Lacaud, University of Manchester, UK (1034)
New Insights into the Endothelial-to-Haematopoietic Transition leading to HSC Emergence
Feng Liu, Institute of Zoology, Chinese Academy of Sciences, China (2015)
Short Talk: p53 mediates loss of hematopoietic stem cells in miR-142a-3p mutants
Tiago Luis, University of Oxford, UK (2016)
Short Talk: Embryonic thymopoiesis is initiated by immune-restricted lympho-myeloid progenitor independently of Notch signaling

13:30 - 15:00 Room B-2 Session 14B: Xenotransplantation Models
*Claudia Waskow
, TU Dresden, Germany
*Koichi Akashi, Kyushu University School of Medicine, Japan
Markus Manz, UniversitätsSpital Zürich, Switzerland (1035)
Improving Humanized Mice for Hematology/Hemato-Oncology Research
Fumihiko Ishikawa, RIKEN, Japan (1036)
Developing Therapeutic Strategies Targeting Poor Prognosis Acute Myeloid Leukemia
Ayano Yurino, Kyushu University, Japan (2017)
Short Talk: Kit mutation enhanced human megakaryo-erythroid reconstitution in xenotransplantation system
Satoshi Yoshihara, Hyogo College of Medicine, Japan (2018)
Short Talk: Stem cell factor, GM-CSF, and IL-3-transgenic humanized mice develop fatal hemophagocytic lymphohistiocytosis;
15:00 - 17:00 Room A Session 15: New Investigator Award Session
*Michael Milsom
, DKFZ/HI-STEM, Germany
*Sofie Singbrant Soderberg, Lund University Sweden
Fernando Camargo, Boston Children's Hospital, USA (1037)
Clonal Analysis of Native Hematopoiesis
Roman Galeev, Lund University, Sweden (2019)
Short Talk: Cohesin genes are critical regulators of HSC renewal
Julien Patenaude, Institute for Research in Immunology and Cancer (IRIC). Canada (2020)
Short Talk: Elucidating the post-natal role of SCA1+ thymic mesenchymal cells

Diana Dou, Broad Stem Cell Research Center, UCLA, USA (2021)
Short Talk: Medial HOXA gene expression is required for establishing “stemness” in human HSCs
Isabel Beerman, Harvard University/Boston Children's Hospital, USA (2022)
Short Talk: Age-associated Clonal Dominance of Myeloid-biased HSC is Underwritten by Unique Transcriptional and Epigenetic Alterations
Bastien Gerby, Institute of Research in Immunology and Cancer (IRIC), Canada (2023)
Short Talk: Targeting pre-leukemic stem cells in T-acute lymphoblastic leukemia
Amelie Guitart, MRC Centre for Regenerative Medicine, University of Edinburgh, UK (2024)
Short Talk: Dual function of fumarate hydratase in haematopoietic stem cell fates
17:00 - 17:15 Foyer Break
17:15 - 17:30 Room A ISEH Annual Business Meeting
17:30 - 18:15 Room A Session 16: McCulloch & Till Lecture
*Paul Frenette
, Albert Einstein School of Medicine, USA
Andreas Trumpp, DKFZ/HI-STEM, Germany (1038)
Global Regulatory Networks and Myc regulation in HSCs and early Progenitors;
18:15 - 18:30 Room A Closing Remarks
19:00 - 22:00 Swan Annual Social Event
(pre-registration required)

* indicates Session Chair
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Funding for this conference was made possible (in part) by 1R13HL129731-01 from the National Institutes of Health. The views expresses in written conference materials or publications and by the speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

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