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ISEH 43rd Annual Scientific Meeting: Schedule of Events
 (as of 22 August 2014)

Thursday, 21 August 2014

1500

Welcome & Opening Remarks

1500 – 1600

Session 1: Donald Metcalf Lecture
Grand Salon Opera
Chair: Paul Frenette

Toshio Suda, Keio University, Japan
Hematopoietic Stem Cells and Niche cells Under the Stress

1600 – 1630

Break 

1630 - 1800

Session 2: Canadian Sampler: Novel approaches for HSC expansion
Grand Salon Opera
Chairs: Paul Frenette and Margaret Goodell

Gordon Keller, Ontario Cancer Institute, Canada
Generation of Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells

Derrick Rossi, Harvard University, USA
Making Hematopoietic Stem Cells: Forwards and Backwards

Guy Sauvageau, University of Montréal/IRIC, Canada
Exploring Small Molecules to Expand Human Stem Cells for Transplantation 

 

1800 – 1930

Welcome Reception
Terrace


Friday 22 August 2014
*Short talks are presented by those whose abstracts are selected for oral abstract presentation

 700-800               New Investigators Meet the                                       Expert Breakfast 
                         
Ovation 
 

                     Grand Salon Opera B

Grand Salon Opera A

800 - 1000

Session 3: Developmental Biology I
Chairs: Elaine Dzierzak and Patricia Ernst 

George Daley, Harvard Medical School, USA

Milestones and Barriers in Hematopoietic Stem Cell Derivation from Pluripotent Stem Cells 

Roger Patient, Oxford, United Kingdom
Programming Blood Stem Cells During Development 

Abstract Presentations 

Ann C. Zovein, , University of California San Fransisco, USA
Balancing Hematopoietic Cell Fate and Endothelial Identity in Hemogenic Endothelium 

Kathleen E. McGrath, University of Rochester, USA
Emergence of the Neutrophil Lineage in the Mammalian Embryo 

Adriana De Le Garza-Sauceda, Albert Einstein College of Medicine, USA
Interactions between the Chromatin Remodeller Chd1 and the Spliceosome are Critical for Hematopoietic Stem and Progenitor Cell Emergence 

Mauricio Cortes, Beth Israel Deaconess Medical Center, USA
Vitamin D Regulates Hematopoietic Stem Cell Maintenance by Two Distinct Mechanisms 


Session 4: ISEH-CNTRP Joint Translational Symposium - Prospects for Cell Therapy 
Chairs: Guy Sauvageau and Hal Broxmeyer

Michel Sadelain, Memorial Sloan-Kettering Cancer Center, USA
Immune Engineering 

Denis-Claude Roy, University of Montréal, Cananda 
Functional T-cells without Alloreactivity 

Abstract Presentations 

Maria Dahl, Lund University, Sweden
Safe Lentiviral Vectors with Cellular and Myeloid Promoters Driving Glucocylceramidase Expression Corrects Tyoe 1 Gaucher Disease 

Fanching Lin, National Cancer Institute, USA
IFN-gamma Causes Aplastic Anemia by Altering HSC Composition and Interrupting Lineage Differentiation 

Simon Haas, German Cancer Research Center, Germany
Inflammation-driven fast-track Differentiation of HSCs into the Megakaryocytic Lineage 

Katherine Y. King, Baylor College of Medicine, USA 
Type II Interferon Promotes Differentiation of Myeloid-Biased Hematopoietic Stem Cells 

1000 – 1030

Break

1030 – 1230

Session 5: Epigenetics I
Grand Salon Opera B
Chairs: Tarik Moroy and Igor Slukvin

Sonia Cellot, CHU Saint Justine, Canada
RNAi Functional Screen Involving Jumonji Family Gene Candidates Identifies Kdm5b/Jarid1b as a Regulator of Mouse Hematopoietic Stem Cell Fate 

Julie Lessard, IRIC, Canada
An Exchange of Alternative ATPasses within BAF Complexes Accompanies the Transition from Hemopoietic Stem Cell Quiescence to Proliferation 

Toshio Kitamura, The University of Tokyo, Japan
Modeling the Hematological Malignancies in Mice 

Abstract Presentations 

Yoshihiro Takihara, Hiroshima University, Japan
Direct Transduction of a Cell-penetrating Form of Geminin, a Molecule Regulating DNA Replication and Chromatin Remodeling 

Matilda Billing, Lund University, Sweden
Identification of a Transcriptional Regulatory Network between TGFβ/Smad4, Gata2, and p57 in Hematopoietic Stem/progenitor Cells 

Linda T. Vo, Boston Children's Hospital, USA
Engineering Hematopoietic Stem and Progenitor Cells from Human Pluripotent Stem Cells for Modeling Congenital Anemias 

Session 13: MPN
Grand Salon Opera
Chairs: Connie Eaves and Ravi Majeti

Ben Ebert, Harvard Stem Cell Institute, USA 
The Molecular Basis of Myelodysplastic Syndromes

Lambert Busque, Hospital Maisonneuve-Rosemont, Canada 
Senescence Dependent Genomic Mutagenesis and the Development of Myeloid Cancers

Keisuke Ito,  Albert Einstein College of Medicine, USA
Metabolic Requirements in the Maintenance of Self-Renewing Stem Cells 

Abstract Presentations

Stephen Shiu-Wah Chung, Memorial Sloan Kettering Cancer Center, USA
CD99 is a Therapeutic Target on Disease Stem Cells in Acute Myeloid Leukemia and the Myelodysplastic Syndromes 

Cyrus Khandanpour, UE, USA
Gfi136N is a Prognostic Marker and Possible Target for the Progression of MDS to AML 

H. Leighton Grimes, Cincinnati Children's Hospital, USA
Single Cell Transcriptome-based Dissection of Lineage Fate Decision in Myelopoiesis

1230 - 1400

Lunch on Own - Explore Montréal 

New Investigator Session 1: Alternative Careers 
Ovation (lunch included in session)

1400-1600

Session 7: Developmental Biology II
Grand Salon Opera B
Chairs: David Traver and Teresa Bowman

James Palis, University of Rochester Medical Center, USA
Early Ontogeny of Hematopoiesis Emergence of Blood before a Blood Stem Cell 

David Traver, University of California, San Diego, USA
Proinflammatory Signaling is Required for Hematopoietic Stem Cell Emergence 

Elaine Dzierzak, University of Edinburgh, United Kingdom
The Program of Endothelial-to-hematopoietic Transtion (EHT) and HSC Generation

Abstract Presentations 

Alaa Alfred Arraf, Technion Israel Institute of Technology, Israel
Generation of Dorsal Aorta Hemogenic Endothelium Involves Replacement of the Ventral Aortic Lining with Cells Derived from the Coelomic Epithelium 

Pedro J. Real, Joseph Carreras Leukemia Research Institute, Spain
RUNX1c Regulates Hematopoietic Specification of Human Embryonic Stem Cells 

Troy Lund, University of Minnesota, USA
Role of tp53 in the Oxidative Stress Response of Erythroid Precursors 

1600-1630

Break - Soprano

1630-1830

Session 8: Controversies in Experimental Hematology Cancer Stem Cell
Grand Salon Opera B
Chair: Sten Eirik Jacobsen

Sean Morrison, UT Southwestern, USA 
Haematopoietic Stem Cell Self-renewal and Leukemogenesis 

Scott Armstrong, Memorial Sloan Kettering Cancer Center, USA
Chasing Leukemia Stem Cells 

Extended Discussion

Abstract Presentations 

Brian Liddicoat, St. Vincent's Institute, Australia 
RNA Editing is the Primary in vivo Function of ADAR1 and is Essential for Hematopoiesis

Céline Moison, IRIC, Canada
E4F1 is an Integral Part of the ATR/Chk1 DNA Damage Pathway


Myriam Grunewald, Hadassah Medical School, Israel 
VEGF Creates Bone-free Extramedullary Niches for Hematopoietic Stem Cells 




1830-2030

Poster Viewing & Discussion (Odd numbered posters)

2030 - 2130

New Investigator Networking Event
SIX Resto Lounge

Saturday 23 August 2014

800 - 1000

Session 9: Leukemia 
Grand Salon Opera
Chairs: Tim Ley and Uli Steidl 

Claus Nerlov, University of Edinburgh, United Kingdom 
Lessons from Modeling CEBPA Mutant Acute Myeloid Leukemias 

Tarik Moroy, IRCM, Canada 
The Zinc Finger Protein Gfi1 Maintains Development and Progression of Lymphoid Leukemia by Blocking the Activation of the Tumor Suppressor 

Ravi Majeti, Stanford University, USA
Clonal Evolution of Pre-Leukemic Hematopoietic Stem Cells in Human Acute Myeloid Leukemia 

Abstract Presentations 

Christos Gekas, IMIM, Spain
Suppression of Notch1-dependent T-cell leukemia by β-catenin Inhibition 

Cedric Stevens Tremblay, Monash University, Australia 
CDKN1A (p21) is Required for Quiescence, Therapeutic Resistance and Clonal Evolution of Pre-leukemic Stem Cells 

Patricia Ernst, Dartmouth, USA
The Histone Methyltransferase Activity of MLL1 is Dispensable for Hematopoiesis and Leukemogenesis 

1000 - 1030

Break - Soprano

1030 - 1200

Session 10: Stem Cell Niche
Grand Salon Opera
Chairs: Toshio Suda and Francois Mercier 

Andreas Trumpp, German Cancer Research Center, Germany
Mesenchymal and MDS Stem Cells Shape an Interactive Disease Unit in the Bone Marrow 

Linheng Li, Stowers Institute for Medical Research, USA
Comprehensive Analyses of Hematopoietic Stem Cell Niches

Abstract Presentations 

Diana Ramirez-Bergeron, Case Cardiovascular Research Institute, USA
Endothelial-ARNT is Critical for the Maintenance and Regeneration of the Bone Marrow

Ingmar Bruns, AECOM, USA
Megakaryocytes Regulate Hematopoietic Stem Cell Quiescence via CXCL4 Secretion 

Andreas Reinisch, Stanford University, USA
An In Vivo Model of Primary Myelofibrosis using a Humanized Bone Marrow Niche Reveals Disease-initiating Cells Enriched in the CD34+/CD38-/CD90+ Hematopoietic Compartment 

1200 – 1330

Janssen Lunch Symposium pre-registration require 
(lunch provided)
Grand Salon Opera

Yusri Elsayed,
MD, MHSC, PhD, Vice President, Hematological Malignancy Group and Aleksandra Rizo, MD, PhD, Senior Director, Clinical Research
An overview of Janssen Research & Development, with a focus on the Hematological Malignancies Group

1330 - 1530

Session 11: New Investigator Session
Chair: Teresa Bowman

Simón Mendéz-Ferrer, Spanish National Center for Cardiovascular Reseach, Spain
Novel Neuroendocrine Regulation of Bone Marrow Stem Cells Provides Potential Combines Therapeutic Targeting of Leukaemic Stem Cells and their Microenvironment 

Student Award Abstract Presentations 

Jeffery Bernitz, Mount Sinai, USA
Label Retention Selects for Hematopoietic Stem Cells in Aged Bone Marrow and Distinguishes HSCs from Myeloid Restricted Progenitors 

Albert D. Kim, University of California, San Diego, USA
Notch3 is Required in the Somitic Microenvironment for the Specification of Hematopoietic Stem Cells 

Jalal Ahmed, Mount Sinai, USA
Ductus Venosus-associated Pericytes form a Niche Regulating Hematopoietic Stem Cell Proliferation in the Fetal Liver

Post-Doc Award Abstract Presentations

Magali Humbert, IRIC, Canada
LMO1/2 Regulates DNA Replication in Hematopoietic Cells 

Yoshihiro Hayashi, Cincinnati Children's Hospital Medical Center, USA
Modeling and Targeting MLL-PTD/RUNX1 Related MDS/AML in Mouse

Daniel D. Lipka, German Cancer Research Center, Germany
Whole-genome Bisulfite Sequencing of HSCs and their Immediate Progeny Identifies Novel Regulatory Elements Involved in Self-renewal and Early Hemotopoietic Commitment 

1530 - 1600

Break - Soprano 

1600 - 1730

Session 12: Presidential Symposium
Grand Salon Opera
Chair: Margaret Goodell

Connie Eaves, BC Cancer Agency, Canada 
New Insights on Clonal Growth In Vivo from Barcoded Transplants 

Tony Green, Cambridge Institute for Medical Research, United Kingdom
MPN Tales and a Point of Order 

Timothy Ley, Washington University School of Medicine, USA
The AML Genome(s)


1730 - 1745

1745 - 1945

Presentation of the New Investigator Awards
Grand Salon Opera
Posters Viewing & Discussion


 

2030 - 2400

Social Event (pre-registration required)
Grand Salon Opera

Sunday 24 August 2014

830 – 1030

Session 6: Immunology of Transplantation
Grand Salon Opera A
Chairs: H. Leighton Grimes and Hideo Ema

Marcel Ven Der Brink, Memorial Sloan-Kettering Cancer Center, USA
Epithelial Regeneration During Graft-versus-Host Disease 

Marie-Josee Hebert, University of Montréal, Canada 
Extracellular Vesicles as Modulators of Humoral Auto-immune Responses: Relevance to Transplantation 

Claude Perrault, IRIC, Canada 
The immunopeptidome of normal and neoplastic cells 


Abstract Presentations 

Anna E. Beaudin, University of California, Santa Cruz, USA
Developmental Layering of Immune Cell Production is Regulated by a Developmentally Restricted Hematopoietic Stem Cell

Sandrine Sarrazin, Centra d'Immunologie de Marseille-Luminy, France
Integration of Cell Cycle Control and Cell Fate Choice in M-CSF-instructed Myeloid Lineage Commitment of Hematopoietic Stem Cells


Hao Yuan Kueh, California Institute of Technology, USA
Macrophage and T-cell fate control: insights from tracking transcription factor dynamics in single cells 

1030 – 1100

Break - Grand Salon Opera Foyer

1100 – 1200

Session 14: Stem Cell Aging
Grand Salon Opera
Chairs: Emanuelle Passagué and Chris Park

Hartmut Geiger, Cincinnati Children's Hospital, USA
Stem Cell Epipolarity: Aging, Wnt, Cdc42 and Beyond

Abstract Presentations

Christopher Y. Park, Memorial Sloan-Kettering Cancer Center, USA
Anti-aging Interventions Reverse Hematopoietic Stem Cell Aging via Regulation of MicroRNAs 

Monika S. Kowalczyk, The Board Institute, USA
Single Cell RNA-Seq of Hematopoietic Stem Cells Reveals a Cell Cycle-dependent Interplay between Aging and Differentiation 

1200 - 1330

Lunch on Own  - Explore Montréal  

New Investigator Session 2: OMICS: A Practical Guide 

Ovation (lunch included in session)

1330 - 1515

Session 15: Lineage Specification II
Grand Salon Opera
Chairs: Toshio Suda and Britta Will

Sten Eirik Jacobsen, University of Oxford, United Kingdom
Emergence of Fetal Immune Restricted Lympho-myeloid Progenitors prior to Definitive Hematapoietic Stem Cells

Trang Hoang, IRIC, Canada
Oncogenic Transcription Factors, from Hematopoietic Stem Cells to Thymocyte Reprogramming 

Jonas Larsson, Lund Stem Cell Center, Sweden
Defining Novel Regulators of Human Hematopoietic Stem/progenitor Cells 

Abstract Presentation

Larry Luchsinger, Columbia University, USA
Prdm16 Regulates Mitochondrial Dynamics and Hematopoietic Stem Cell Function

1515 – 1545

Break - Grand Salon Opera Foyer

1545 – 1600


1600 - 1700

Annual General Meeting 
Grand Salon Opera

Session 16: McCulloch & Till Lecture
Grand Salon Opera
Chair: Margaret Goodell

Emmanuelle Passegué, University of California San Francisco, USA 
De-constructing Hematopoietic Stem Cell Biology  

1700

Closing Remarks - Grand Salon Opera

 

 

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