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March 2011 ISEH Newsletter
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Connections in Hematology & Stem Cells is supported by a grant from

In the March 2011 issue

Fellowship Launched!
Young investigators invited to submit applications for $50,000 fellowship.

Meeting Update
Abstract and registration sites are open for the 25-28 August 2011 meeting in Vancouver.

Experimental Hematology
Meet the publishing team and review the February issue table of contents.

Young Investigators
New Young Investigators Committee outlines plans.

Society News
In memory: Dr. Eugene Goldwasser and Dr. Ernest McCulloch
Your ISEH membership provides many benefits.

News from the Field
What do you want from this Connections in Hematology & Stem Cells e-newsletter?

Member Profile
Get to know Experimental Hematology Editor-in-Chief Keith Humphries.


Fellowship Launched to Support Young Investigator

 

ISEH is proud to announce The ISEH Eugene Goldwasser Fellowship, supported by Amgen for an outstanding young investigator in the field of hematology. The Society gratefully acknowledges Amgen for their funding.

"The ISEH Awards Committee is extremely excited to add this impressive fellowship to our menu of awards recognizing significant contributions to the experimental hematology field,” states Gay Crooks, PhD, chair of the committee. "The ISEH mission directs us to support the young investigator and enhance scientific knowledge. The ISEH fellowship provides a concrete means of helping a young investigator in his or her career path.”

This fellowship celebrates the stunning career of Dr. Goldwasser, who died December 17, 2010. He joined ISEH in 1972 and continuously promoted efforts to involve, energize and mentor young investigators. A major contributor to the field, Dr. Goldwasser is best known for isolating and purifying erythropoietin, or EPO, a protein that spurs the body to produce red blood cells. He shared this material with a young biotechnology company, which discovered how to use genetic engineering to produce larger amounts of the protein. That company was Amgen.

The fellowship will be a one-year, non-renewable $50,000 grant payable to the awardee's institution for salary and/or other research support. The investigator's research may be basic or translational with a focus on experimental hematology, hematologic malignancies, hematopoiesis or stem cell biology as it relates to hematology.

Applications will be accepted from March 10 through May 10 and applicants must be post doctoral fellows at an academic institution, two to five years since beginning the research dimension of their postgraduate training if MD, MD/PhD, DDS or DVM or postgraduate if PhD degree. The applicant and the lab principal investigator must be ISEH members to be considered. Not a member? Join ISEH by clicking here.

Application Format

Applicants should submit a research proposal that should be no more than three pages, excluding references, as well as a one-page personal statement. A proposed budget for the research fellowship should be included, along with the candidate's curriculum vitae, a supporting letter and biosketch from a mentor plus an additional reference letter. Watch www.iseh.org for additional information.

Review Criteria

Submissions will be reviewed by the ISEH Awards Committee and rated according to the qualifications of the candidate and the scientific value of the proposed project. Preference will be given to applications demonstrating novelty or initiative on the part of the applicant, either to achieve progress in a specific project or to master new technology. The final decision will be made by the ISEH Executive Committee by June 15, and the award will be presented at the ISEH Annual Scientific Meeting in Vancouver, 25-28 August 2011.

"We invite all ISEH young investigators to apply for this fellowship," Dr. Crooks encourages. "Being selected would be a great next step in your career."

Click here to view the fellowship information page.


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Annual Scientific Meeting

25-28 August, Westin Bayshore Hotel, Vancouver, Canada
Register
Submit an Abstract
Meeting Information

Registration is open and ISEH is accepting abstracts for the ISEH 40th Annual Scientific Meeting, 25-28 August 2011, in Vancouver, Canada. This exclusive meeting is the annual forum for the exchange and discussion of original, unpublished and significant research advances in the areas of hematology and stem cell biology. Take action today to participate.

"The Vancouver meeting will attract the very best in the field of hematology and stem cell biology,” touts David Scadden, MD, meeting chair. This international meeting is the ideal mix of intimate size and groundbreaking science. It has a casual, friendly atmosphere that's just right for exchanging ideas between experienced scientists and young investigators alike.”


Submit an Abstract

The abstract submission page is open and ISEH will accept abstracts until 15 April 2011. Members and non-members are invited to submit, although there will be a $50 fee for non-members. ISEH members can submit free of charge. Submit now.

Scientific program categories include:

  • Re-programming and Epigenetics
  • HSC Biology
  • Progenitor Cell Biology
  • Microenvironment
  • Aging
  • Transplantation/Gene Therapy/Regenerative Medicine
  • Leukemia: Clinical/Experimental
  • Lymphoma
  • Developmental Biology
  • Genomics
  • Signaling
  • Transcriptional Control

See confirmed speakers.

From 10 June to 8 July, ISEH will accept late breaking abstract submissions.

Register for Meeting

Get ahead of your calendar and register today for the meeting. All registrations received before 24 June are highly discounted. Check out the discounts for member, associate/student and day rate.

Make Hotel Reservations

Secure the ISEH hotel rate of CAD $199 at the Westin Bayshore Vancouver, site of all meeting activities.

Vancouver

The vibrant local hematology and stem cell community make this thriving international city a great spot for the ISEH Annual Scientific Meeting. It is convenient for our members traveling from Asia Pacific and North America, and the August timeframe allows our European members to attend at the end of holiday season.

Watch for additional information on special ISEH events, like the ISEH Social Event: cruising the Vancouver Harbour aboard the Harbour Princess on Saturday night with drinks, hors d'oeuvres, music, and dancing. The ISEH Social Event is supported by STEMCELL Technologies, Inc.

Get Involved with Fellow Attendees Now!

One feature of our new ISEH website is to display names of those who have registered for the Annual Scientific Meeting. This allows the community to connect before the meeting, plan agendas, share travel, etc. Don't see a name of a colleague you know would benefit from the meeting? Send them and note and encourage them to attend!

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Experimental Hematology

Experimental Hematology keeps you up-to-date on the latest research emerging in our field.

"Experimental Hematology is where you should be published if you are working on hematopoietic stem cells, hematologic malignancies and the exciting emerging areas of model organisms and genomics as applied to normal and malignant hematopoiesis,” explains Keith Humphries, MD, PhD, editor-in-chief.

Dr. Humphries began the editor's role in January 2011 and announced his associate editors:

Koichi Akashi, MD, PhD
Dept. of Medicine and Biosystemic Science, Kyushu University, Japan

Gerald de Haan, PhD
Department of Stem Cell Biology, University Medical Centre, Groningen, The Netherlands

Bertie Göttgens, PhD
Cambridge Institute for Medical ResearchCambridge University, United Kingdom

Toshio Kitamura, PhD
The Institute of Medical Science, University of Tokyo, Japan

Susie Nilsson, PhD
Commonwealth Scientific and Industrial Research Organisation, Material Science and Engineering, Melbourne, Australia

David Traver, PhD
Division of Biological Science, UC San Diego, USA

Mervin Yoder, MD
Dept. of Pediatrics and Dept. of Biochemistry and Molecular Biology, Indiana University, USA

Axel Zander, MD
Bone Marrow Transplantation Center, University Hospital Hamburg-Eppendorf / Germany

Esmail Zanjani, PhD
Department of Animal Biotechnology University of Nevada, USA

The publishing team seeks manuscripts describing research involving in vivo and ex vivo studies in the following areas: cell cycle regulation, cytokines, erythropoiesis, gene therapy, general hematopoiesis, granulopoiesis, hematological malignancies, immunobiology, immunotherapy, lymphopoiesis, megakaryocytopoiesis, microenvironment, monocyte development, molecular genetics, signal transduction, stem cell biology, and experimental as well as clinical stem cell transplantation.

View the full Editorial Board. Also, you can read more about Dr. Humphries in this issue's profile.

February 2011 – Volume 39, Issue 2

Scan the current issue's contents below, clicking through to articles of interest to you. All issues are available to ISEH members on the Experimental Hematology website.

Review Article
Regulation and deregulation of mRNA translation during myeloid maturation
Arati Khanna-Gupta

Cytokines
Transient neutropenia after granulocyte-colony stimulating factor administration is associated with neutrophil accumulation in pulmonary vasculature
Catherine E. DeJesus, Jackson Egen, Mark Metzger, Xavier Alvarez, Christian A. Combs, Daniela Malide, Zu Xi Yu, Xin Tian, Robert E. Donahue

General Hematopoiesis
Annexin-2 is a regulator of stromal cell-derived factor–1/CXCL12 function in the hematopoietic stem cell endosteal niche
Younghun Jung, Yusuke Shiozawa, Jingcheng Wang, Lalit R. Patel, Aaron M. Havens, Junhui Song, Paul H. Krebsbach, G. David Roodman, Russell S. Taichman

MicroRNA-146a disrupts hematopoietic differentiation and survival
Daniel T. Starczynowski, Florian Kuchenbauer, Joanna Wegrzyn, Arefeh Rouhi, Oleh Petriv, Carl L. Hansen, R. Keith Humphries, Aly Karsan

Hematological Malignancies
High expression of 67-kDa laminin receptor relates to the proliferation of leukemia cells and increases expression of GM-CSF receptor
Koji Ando, Yasushi Miyazaki, Yasushi Sawayama, Shinya Tominaga, Emi Matsuo, Reishi Yamasaki, Yoriko Inoue, Masako Iwanaga, Daisuke Imanishi, Hideki Tsushima, Takuya Fukushima, Yoshitaka Imaizumi, Jun Taguchi, Shinichiro Yoshida, Tomoko Hata, Masao Tomonaga

Leukemia cells invading the liver express liver chemokine receptors and possess characteristics of leukemia stem cells in mice with MPD-like myeloid leukemia
Alexey E. Bigildeev, Irina N. Shipounova, Daria A. Svinareva, Nina J. Drize

Telomere deregulations possess cytogenetic, phenotype, and prognostic specificities in acute leukemias
Valérie Capraro, Linda Zane, Delphine Poncet, David Perol, Perrine Galia, Claude Preudhomme, Nathalie Bonnefoy-Berard, Eric Gilson, Xavier Thomas, Mohamed El-Hamri, Youcef Chelghoun, Mauricette Michallet, Eric Wattel, Franck Mortreux, David Sibon

Stem Cell Biology
Development of a high-resolution purification method for precise functional characterization of primitive human cord blood–derived CD34–negative SCID-repopulating cells
Mari Ishii, Yoshikazu Matsuoka, Yutaka Sasaki, Ryusuke Nakatsuka, Masaya Takahashi, Tsuyoshi Nakamoto, Katsuhiko Yasuda, Kazuo Matsui, Hiroaki Asano, Yasushi Uemura, Takashi Tsuji, Shirou Fukuhara, Yoshiaki Sonoda

Human adipose tissue−derived mesenchymal stem cells facilitate the immunosuppressive effect of cyclosporin A on T lymphocytes through Jagged-1−mediated inhibition of NF-κB signaling
Dan Shi, Lianming Liao, Bin Zhang, Rui Liu, Xiaowei Dou, Jing Li, Xishan Zhu, Limei Yu, Daixiong Chen, Robert C.H. Zhao

Stem Cell Plasticity
Adult murine bone marrow-derived very small embryonic-like stem cells differentiate into the hematopoietic lineage after coculture over OP9 stromal cells
Janina Ratajczak, Marcin Wysoczynski, Ewa Zuba-Surma, Wu Wan, Magda Kucia, Mervin C. Yoder, Mariusz Z. Ratajczak

Stem Cell Transplantation
Steroid treatment alters adhesion molecule and chemokine expression in experimental acute graft-vs.-host disease of the intestinal tract
Abdellatif Bouazzaoui, Elena Spacenko, Gunnar Mueller, Elisabeth Huber, Thomas Schubert, Ernst Holler, Reinhard Andreesen, Gerhard C. Hildebrandt

Differential survival of AML subpopulations in NOD/SCID mice
Mario Schubert, Nicolás Herbert, Isabel Taubert, Dan Ran, Rahul Singh, Volker Eckstein, Mario Vitacolonna, Anthony D. Ho, Margot Zöller

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Young Investigators

Committee Takes Its First Steps

Late last year, ISEH formed a Young Investigators Committee to direct the Society's efforts with this important niche of the membership. The committee is responsible for representing the needs and ensuring the development of young scientists as they move forward in their careers.

The committee currently is comprised of seven young investigators who will take their combined insights and develop plans for this membership segment. Committee Chair Shannon McKinney-Freeman, PhD, assistant member, Department of Hematology at St. Jude Children's Research Hospital in Memphis, Tenn., USA, sees the committee's primary responsibilities as two-fold.

"Our immediate priorities include developing useful website content and meaningful Annual Scientific Meeting experiences for young investigators,” McKinney-Freeman explains. "As with all areas of ISEH, we will be mindful of the truly global audience and strive to make connections between young and senior investigators.”

For example, the committee plans to develop a list of grant opportunities for the website, organized by different levels and reaching beyond the North American focus of most current lists. Most visible to all members will be the committee's Annual Scientific Meeting efforts.

"Helping structure young investigator events for the Annual Scientific Meeting is the biggest opportunity our committee has to have the greatest impact,” she adds. "There is a hunger from young investigators to have more information about career paths and the job search process and to have meaningful interaction with senior investigators.”

To that end, there are plans to once again offer the "Meet the Professor Breakfast” at the 2011 meeting in Vancouver, as well as other events that provide access for young investigators to interact with one another and with those more advanced in their careers.

The Young Investigators Committee includes McKinney-Freeman (USA), Teresa Bowman (USA), Marie-Dominique Filippi (USA), Jochen Grassinger (Germany), Zhenyu Ju (China), Isao Kobayashi (Japan) and Florian Kuchenbauer (Germany).

"We invite the input of other young investigators,” McKinney-Freeman states. "If you have ideas and energy, please get in touch!”

 

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Society News

In Memory: Dr. Eugene Goldwasser and Dr. Ernest McCulloch

ISEH acknowledges with sadness the passing of Dr. Eugene Goldwasser on December 17, 2010 and Dr. Ernest McCulloch on January 19, 2011. These two ISEH greats were pioneers in hematopoiesis and stem cells.

Dr. Goldwasser was widely considered to be the "father of EPO” with his epic work that led to the purification of erythropoietin and subsequent cloning and widespread use of EPO clinically. He was a founding member of ISEH in 1972 and always leant his insight and support to the Society, even as an emeritus member. To honor his ISEH contributions, The ISEH Eugene Goldwasser Fellowship, supported by Amgen, will be awarded for the first time in 2011.

Dr. McCulloch, with his long time collaborator Dr. James Till, is credited as ushering in the modern era of stem cell biology with the discovery of the CFU-S assay and enormous conceptual advances in the nature and regulation of both normal and leukemic stem cells. He joined ISEH in 1992 and also stayed actively involved with the Society as an emeritus member. The annual McCulloch and Till Award for a young investigator bears his name.

Complete obituaries will be included in the March issue of Experimental Hematology. Links to additional information are provided below.

http://www.nytimes.com/2010/12/21/health/21goldwasser.html

http://www.news.utoronto.ca/health-and-medicine/remembering-ernest-mcculloch.html

Membership = Eligibility & Discounts

ISEH members are entitled…you are entitled to apply for the new ISEH Eugene Goldwasser Fellowship, supported by Amgen (and be considered for other ISEH awards). You are entitled to submit abstracts for the Vancouver meeting at no charge. You are entitled to register for the meeting at discounted rates. Mostly, you are entitled to interact with one another throughout the year.

Be sure your ISEH membership is paid, so you can take advantage of all the Society has to offer to connect with more than 800 researchers in your field. Questions? Contact Laura Williams at membership@iseh.org or +1.312.321.5114. Office hours are 9 a.m. 5 p.m., CST. Members in other time zones are invited to leave a message for prompt response by staff.

Be sure to also update your member profile, so that members and staff know how to reach you. It is easy to do with the new web platform.

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News from the Field

Is there a meeting you had hoped to attend? Or, is there a topic you would like ISEH to address? Send your ideas to editor@iseh.org and perhaps our scientific editor can respond.


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Member Profile...

ISEH, comprised of industry leaders in hematology, immunology, stem cell research, and cell and gene therapy, connects members worldwide for the opportunity to advance scientific knowledge. Each issue of Connections in Hematology & Stem Cells will introduce you to a few of those members. This issue, meet Keith Humphries.

Keith R. Humphries, MD, PhD
Director/Senior Scientist, Terry Fox Lab, BC Cancer Agency
Professor, University of British Columbia
Editor-in-chief, Experimental Hematology

 

Keith Humphries is an accomplished scientist who, like many in our field, came upon a project and colleagues who helped shape his career path.

"My undergraduate degree was in physics and math and I was fully committed, I thought, to build on this with my enrollment in the medical biophysics graduate program at the Ontario Cancer Institute (OCI),” Dr. Humphries recalls. "These were the heady days, 1970-71, when Jim Till, Ernest McCulloch, Rick Miller (my supervisor) and a host of others (e.g., Connie Eaves, Norman Iscove, Alan Bernstein, Makio Ogawa to name just a few) at the OCI were carrying out pioneering studies in cell purification, hematopoietic assays, stem cells and transplantation. I caught the stem cell bug and said goodbye to physics and hello to working on hematopoietic stem cells. I took the plunge into medicine, followed this up with PhD studies with Connie Eaves who had started an exciting new lab in Vancouver and then postdoctoral work with Art Nienhuis at the National Institutes of Health. Since returning to Vancouver in 1984, I have been incredibly fortunate to work along side an incredibly collaborative and collegial group at the Terry Fox Laboratory and have been able to indulge my passion for stem cells of both the normal and leukemic variety.”

His research focuses on understanding the genetic determinants of normal and leukemic hematopoietic stem cell properties with the goal of developing new methods to enhance expansion of normal stem cells for transplantation based therapies and new targets to suppress leukemic stem cell growth. To that end, he has published nearly 200 articles in leading scientific publications such as Blood, Cell Cycle, Experimental Hematology and Science.

An ISEH past president, Dr. Humphries recently became editor-in-chief of Experimental Hematology.

"ISEH has been a big part of my professional life since my first attendance as a graduate student at the annual meeting held in Basel, Switzerland in the late ‘70s,” he shares. "I was immediately impressed by the intimacy of the meeting and the ability to ‘rub shoulders' with senior people like Don Metcalf and also make life-long connections with more many others. Beyond the annual meeting, the journal Experimental Hematology was already running full tilt and was a must read for me as well as a conduit for many of my papers over the years. Taking on the role of editor-in-chief after several years as an associate editor gives me a chance to work with a large number of enthusiastic people who value our journal's role as a major publication in the stem cell and hematology field and as a major force in our society. There are challenges to keeping the journal vibrant in face of growing competition but the track record, importance to the Society and quality of the journal encouraged me to take this on.”

He indicates that this strong Experimental Hematology team will help attract articles and further define the scope and emphasis of the journal on hematopoietic stem cells, hematologic malignancies and the exciting emerging areas of model organisms and genomics as applied to normal and malignant hematopoiesis.

Strong journals help many in the field face their professional challenges.

"Thank goodness for Google searches, PubCrawler, PubMed, online access to journals, all of which make it (slightly) possible to keep up in our incredibly rapidly moving field,” Dr. Humphries muses. "Indeed I would say that the success of our field in continuing to provide seminal breakthroughs in stem cells, regenerative medicine, targeted therapies for cancer, systems biology and gene therapy creates a pace that is stimulating but demanding if one is to keep up and remain a competitive force. I also sense a growing trend towards ‘big science' and the need to embrace new technologies such as next generation sequencing and to work as collaborative teams. Embracing this is an exciting challenge. Of course we can all point to the challenge of funding not just our own research programs but in ensuring that we can support the next generation of bright stars.”

Dr. Humphries is a hard worker, but has never considered what he does at the lab as a job, but rather as an incredibly rewarding passion.

"But, there is life outside the lab that revolves around my wife, three fantastic daughters and now many grandchildren. Sailing, fly-fishing, bike riding and the odd trip to my wife's family home in France fill in the remaining bits of time.”

Join Dr. Humphries in his quest to elevate Experimental Hematology to an even higher level. Go to http://ees.elsevier.com/exphem/ for more information on how you can submit.

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