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2010 Scientific Program

 

 



This is the preliminary proposed program, please bookmark this page for updates closer to the conference dates.
Click here to donwload a PDF version of the Scientific Program. (updated as of August, 11 2010)
Click here to view all posters.


Wednesday, September 15

2:00-2:15pm Indigenous Welcome
2:15-2:30pm
Welcome Remarks (Toshio Suda and Susie Nilsson)
2:30-2:40pm Meeting Open Professor David De Kretser (Governor of Victoria)
2:40-3:00pm Don Metcalf Lecture Introduction (Don Metcalf)
3:00-4:00pm Don Metcalf Lecture
Dr. Ihor Lemischka, PhD, The Mount Sinai Medical Center

4:00-4:30pm Coffee Break
4:30 - 6:15 pm Session 1: Clinical Application of Cytokines
Chairs: Andrew Elefanty & Toshio Suda
Speakers: Nick Nicola (Aus); Andrew Roberts (Aus);
Geoff Hill (Aus); Glenn Begley (USA)
6:45 - 8:45 pm Welcome Reception




Thursday, September 16

 

 

7:30 - 8:30 am Poster set up

8:30 - 10:15 am

Session 2: Megakaryocytopoiesis and Microenvironment
Chairs: David Haylock & Ben Kile
Speakers: Doug Hilton (Aus); Larry Lasky (USA)
Abstracts:

#75
MEGAKARYOCYTES POSSESS A FUNCTIONAL INTRINSIC APOPTOSIS PATHWAY,
BUT DO NOT USE IT TO PRODUCE PLATELETS
Author: Josefsson, E.C.

#185
COMPONENTS OF THE PROTHROMBINASE COMPLEX ARE EXPRESSED BY
MEGAKARYOCYTES AND THE ENDOSTEAL REGION OF THE BONE MARROW NICHE
Author: Storan, M.J.

#54
MYELOABLATIVE THERAPIES DAMAGE AND ALTER THE COMPOSITION OF THE CELLS
OF THE BONE MARROW MICROENVIRONMENT
Author: Askmyr, M.

Session 3: Molecular Basis of Leukemia
Chairs: James Mulloy & Stefan Karlsson
Speakers: Koichi Akashi (Japan); Toshio Kitamura (Japan)
Abstracts:

#80
LEUKEMIA STEM CELLS OCCUPY NICHES THAT ARE PHYSICALLY DISTINCT AND
INDEPENDENT OF THE NORMAL CONSTRAINTS THAT APPLY TO HEMATOPOIETIC STEM CELLS
Author: Lane, S.W.

#158
FOXO TRANSCRIPTION FACTORS ARE REQUIRED FOR THE MAINTENANCE OF
ACUTE MYELOID LEUKEMIA
Author: Sykes, S.
Steven W. Lane
Kristina M. Brumme
Demetrios Kalaitzidis
Stefan Fröhling
Claudia Scholl
Ronald A. Depinho
Scott A. Armstrong
D. Gary Gilliland
David T. Scadden (Corresponding)

#98
OVEREXPRESSION OF BCL2 RESCUES APOPTOSIS, CYTOPENIAS
AND LEUKEMIC TRANSFORMATION IN MURINE MYELODYSPLASTIC SYNDROME
Author: Slape, C.I.


10:15 - 10:45 am Coffee Break (served in exhibition area)
10:45 - 12:30 am Session 4: Developmental Hemopoiesis (in memory of Greg Johnson)
Chairs: Merv Yoder & Nick Nicola
Speakers: Chung Li (Taiwan); Georges Lacaud (UK);
Elaine Dzierzak (Holland); Paul Gadue (USA)

Session 5: Animal Models of Leukemiagenesis
Chairs: Gerald de Haan & Koichi Akashi
Speakers: Richard Lock (Aus); Graham Lieschke (Aus)
Mineo Kurokawa (Japan)
Abstracts:

#138
MEIS1 ACTS AS A POTENT COLLABORATOR WITH AML1-ETO IN INDUCING ACUTE
LEUKEMIA IN THE MURINE BONE MARROW TRANSPLANTATION MODEL
Author: Vegi, M.N.
12:30 - 1:15 pm Lunch (served in exhibition area) / Board Meeting
1:15 - 2:45 pm Concurrent Oral Presentation 1: Hemopoiesis
Chairs: Keith Humphries & Hanna Mikkola
Abstracts:

#208
NEITHER SMOOTHENED LOSS- NOR GAIN-OF-FUNCTION IN THYMIC EPITHELIUM
ALTERS NORMAL T-CELL DEVELOPMENT
Author: Göthert J.

#27
THE TRANSCRIPTIONAL INTERMEDIARY FACTOR TIF1GAMMA CONTROLS ERYTHROID
CELL FATE BY REGULATING TRANSCRIPTIONAL ELONGATION
Author: Bai, X.

#149
TRANSCRIPTIONAL ANALYSIS OF HSC ONTOGENY REVEALS NOVEL
DEVELOPMENTAL TRANSITIONS
Author: McKinney-Freeman, L. S.

#85
CYCLIN A2 PLAYS A CRITICAL ROLE IN PROLIFERATION OF LYMPHOID PROGENITORS
Author: Kohno, K.

#120
MYELOID LEUKEMIA FACTOR 1 AFFECTS FETAL ERYTHROPOIESIS AND HAEMOPOIETIC DEVELOPMENT
Author: Winteringham, L.N.

#26
USE OF BARCODED RETROVIRAL VECTORS FOR DETAILED TRACKING OF CLONALITY IN THE HEMATOPOIETIC SYSTEM
Author: Verovskaya, E.

Concurrent Oral Presentation 2: Basic HSC Biology
Chairs: Catherine Verfaillie & Carl Walkley
Abstracts:

#62
A CANDIDATE POLARITY GENE SCREEN IDENTIFIES ENDOCYTIC AP2A2 IN ASYMMETRIC CELL DIVISION
AND EXPANSION OF HAEMATOPOIETIC STEM CELLS
Author: Ting, S.

#115
REGULATED EXPANSION OF HUMAN MYELO-ERYTHROID PROGENITORS USING A LIGAND INDUCIBLE SYSTEM
Author: Parekh, C.

#38
CRIPTO SELECTIVELY EXPANDS A DISTINCT POPULATION OF HEMATOPOIETIC STEM CELLS EXPRESSING
CELL SURFACE RECEPTOR GRP78
Author: Miharada, K.

#110
IL-6 PROMOTES ACUTE AND CHRONIC INFLAMMATORY DISEASE IN THE ABSENCE OF SOCS3
Author: Croker, B.A.

#13
EX VIVO MAINTENANCE OF HEMATOPOIETIC STEM CELLS BY QUIESCENCE INDUCTION
THROUGH FBXW7ALPHA-OVEREXPRESSION
Author: Iriuchishima, H.I.

#50
TRISOMY OF ERG IS REQUIRED FOR MYELOPROLIFERATION IN A MOUSE MODEL OF DOWN SYNDROME
Author: Ng, P.

Concurrent Oral Presentation 3: Recent Advances in Clinical Transplantation
Chairs: Pamela Becker and John Pimanda
Abstacts:

#40
THE PRO-APOPTOTIC PROTEIN, BID, IS A POSITIVE REGULATOR FOR LYMPHOID CELL REGENERATION WITHOUT OBVIOUS IMPACT ON HEMATOPOIETIC STEM/PROGENITOR CELLS
Author: Shen, H.

#126
IL-3 MEDIATED ACTIVATION OF ß-CATENIN IN ACUTE MYELOID LEUKAEMIA
Author: Sadras, T.

#31
GENETICALLY REENGINEERED K562 CELLS SIGNIFICANTLY EXPAND CORD BLOOD (CB) NATURAL KILLER (NK) CELLS WITH INCREASED CYTOLYTIC ABILITY FOR POTENTIAL USE IN ADOPTIVE CELLULAR IMMUNOTHERAPY (ACI)
Author: Cairo, M.

#167
AHI-1 AND JAK2 ARE KEY TARGETS FOR IMATINIB NON-RESPONSIVE PATIENTS WITH CHRONIC MYELOID LEUKEMIA
Author: DeGeer, D.D.

#136
DETERMINING THE CONTRIBUTION OF B CELLS IN REGULATING T CELL ACTIVITY AND GRAFT-VERSUS-HOST DISEASE
Author: Davis, J.

#118
AMD3100 INCREASES THE PROPORTION OF ACTIVELY CYCLING ALL IN THE
PERIPHERAL BLOOD
Author: Welschinger, R.
2:45 -3:15 pm
Coffee Break
3:15 - 5:00 pm
Session 6: Pluripotency to Blood 1
Chairs: Dominique Bonnet & Ihor Lemishka
Speakers: Andrew Elefanty (Monash University); Jim Palis (New York)
Abstracts:

#216
GENERATION OF MATURE EOSINOPHILS FROM HUMAN EMBRYONIC AND INDUCED
PLURIPOTENT STEM CELLS
Author: Ma, F.

#178
ZEBRAFISH GRANULOCYTE COLONY STIMULATING FACTOR (GCSF) ALLOWS IN
VITRO CLONAL ANALYSIS OF ZEBRAFISH STEM AND PROGENITOR CELLS
Author: Stachura, D.L.

#18
HEMATOPOIETIC STEM CELLS MARKED BY JUNCTIONAL ADHESION MOLECULE 1 (JAM1) ARE LOCALIZED ALONG BILATERAL COLLECTING TUBULES IN ZEBRAFISH KIDNEY
Author: Kobayashi, I.

Session 7: BMTS ANZ Session
Chairs: Mike Berridge & Jeff Szer
Speakers: Peter Browett (New Zealand); Juliet Barker (USA);
David Curtis (Aust)
Abstracts:

#92
IDENTIFICATION OF AML STEM CELL-SPECIFIC THERAPEUTIC TARGETS IN AN IN VIVO
MODEL OF HUMAN PRIMARY AML
Author: Saito, Y.

#32
CORD BLOOD TELOMERE LENGTH PREDICTS TRANSPLANT OUTCOME
Author: Elwood, N.J.
5:30 - 6:30 pm Poster Viewing
6:00 - 6:30 pm Poster panel discussion 1

Poster panel disucssion 2
Poster panel discussion 3





Friday, September 17



7:30am -8:30am
Poster set up
8:30 - 10:15 am
Session 8: Pluripotency and blood development
Chair: Teresa Bowman & Gay Crooks
Speakers: Igor Slukvin (USA); John Yu (Taiwan)
Abstracts:

#204
PLACENTAL TROPHOBLASTS REGULATE BOTH PRIMITIVE AND DEFINITIVE HEMATOPOIESIS DURING DEVELOPMENT
Author: Ueno, M.

#35
A RUNX1-SMAD6 RHEOSTAT CONTROLS RUNX1 LEVELS AND REGULATES HAEMATOPOIESIS IN THE DEVELOPING EMBRYO
Author: Pimanda, J.

#19
IDENTIFICATION OF A NOVEL PROTEIN CRITICAL FOR MYELOPOIESIS
Author: Keightley, M.C.

Session 9: HSC Mobilisation and Microenvironment
Chair: Linda Bendall & Chung Li
Speakers: Jean-Pierre Levesque (Aus) and Song Chou (USA)
Abstracts:

#122
SPHINGOSINE-1-PHOSPHATE MEDIATES THE EGRESS OF HEMATOPOIETIC STEM CELLS FROM THE BONE MARROW INTO THE PERIPHERAL BLOOD
Author: Downey, N.

#197
DEPLETION OF BONE MARROW PHAGOCYTES CAUSES THE MOBILIZATION OF LONG-TERM RECONSTITUTING HEMATOPOIETIC STEM CELLS
Author: Jacobsen, R.N.

#212
DIFFERENTIAL ABILITY OF PRE-OSTEOBLASTS AND MATURE OSTEOBLASTS TO SUPPORT ADULT HEMATOPOIETIC STEM CELL SYMMETRIC SELF-RENEWAL
Author: Klug, A. C.
10:15 -10:45 am Coffee Break
10:45 - 12:30 pm Session 10: Vascular Biology
Chair: David Traver & Paul Frenette
Speakers: Merv Yoder (USA); Gay Crooks (USA);
Gou Young Koh (Korea)
Abstracts:

#162
HEMATOPOIETIC STEM AND PROGENITOR CELLS ARE ASSOCIATED WITH STRUCTURALLY DIVERSE TYPES OF BONE MARROW MICROVESSELS
Author: Nombela-Arrieta, C.

Session 11: HSC Homing/Trafficking
Chair: Jochen Grassinger & JP Levesque
Speakers: Steffen Massberg (USA); Amy Wagers (USA)
Abstracts:

#20
BMP4 IMPROVES HEMATOPOIETIC STEM CELL HOMING BY UP-REGULATION OF INTEGRIN-a4 THROUGH SMAD INDEPENDENT PATHWAY
Author: Khurana, S.

#209
INTEGRIN ALPHAIIB (CD41) IS REQUIRED FOR HEMATOPOIETIC STEM CELL DIFFERENTIATION AND ENGRAFTMENT
Author: Gekas, C.

#4
THE FETAL LIVER IS COLONIZED BY AN IMMATURE CELL POPULATION THAT MATURES TO FORM DEFINITIVE HEMATOPOIETIC STEM CELLS
Author: Kieusseian-Grunet de la Grange, A.

12:30 - 1:15 pm Lunch (served in exhibition area) / Journal Editorial Meeting
1:15 - 3:15 pm New Investigator Presentations
Chairs: Ivan Bertoncello & Paul Kincade
PhD Student Abstracts:

#184
HAS3-SYNTHESISED HYALURONAN PARTICIPATES IN DIRECTING THE PREFERENTIAL HOMING OF TRANSPLANTED HEMOPOIETIC STEM CELLS TO THE METAPHYSIS DURING THE INITIAL STAGES OF HOMING
Author: Ellis, S.L.

#55
THE ROLE OF FRESHLY ISOLATED MATURE MEGAKARYOCYTES IN REGULATING HSC FUNCTION IN VITRO AND IN VIVO
Author: Neaves, R.

#79
OVEREXPRESSION OF POLYCOMB GENE CBX7 IN HEMATOPOIETIC CELLS INDUCES DISTINCT TYPES OF LEUKEMIA
Author: Klauke, K.

#200
CANONICAL WNT SIGNALING REGULATES HEMATOPOIESIS IN A DOSAGE-DEPENDENT FASHION
Author: Luis, T.C.

Post-Doc Abstracts:

#169
DIABETES IMPAIRS HEMATOPOIETIC STEM CELL TRAFFICKING
Author: Ferraro, F.

#152
PREVENTION OF CHEMOTHERAPY-INDUCED DAMAGE IN THE HEMATOPOIETIC MICROENVIRONMENT BY NEUROPROTECTION
Author: Lucas-Alcaraz, D.

#87
COMMITMENT OF ENDOTHELIAL CELLS TO A HEMATOPOIETIC FATE IN THE AGM OCCURS BEFORE E10.5
Author: Swiers, G.L.

#188
CHANGES IN THE EPIGENOME ASSOCIATED WITH MEIS1 INDUCED LEUKEMIC TRANSFORMATION
Author: Yung, E.S.
3:15 - 3:30 pm Coffee Break (served in exhibition area)
3:30 - 5:30 pm Presidential Symposium: Stem Cell Niche Interactions
Chair: Toshio Suda
Speakers: Paul Frenette (USA); Susie Nilsson (Aus);
Kateri Moore (USA): David Scadden (USA)
5:30 - 6:30 pm
Poster viewing
6:00 - 6:30pm
Poster panel discussion 4
Poster panel discussion 5
Poster panel discussion 6
7:30 pm Gala Dinner





Saturday, September 18

8:30 - 9:00 am Annual General Meeting
9:00 - 10:00 am McCulloch & Till Lecture
Chair: David Scadden
Bertie Gottgens, DPhil, University of Cambridge
10:00 - 10:30 am Coffee Break
10:30 - 12:15 pm Session 12: Microenvironment
Chairs: Susie Nilsson & Timm Schroeder
Speakers: Paul Kincade (USA); Thalia Papayannopoulou (USA)
Abstracts:

#12
THE ROLE OF TISSUE INHIBITOR OF METALLOPROTEINASE-3 (TIMP-3) IN HAEMATOPOIESIS
Author: Shen, Y.

#146
ABSENCE OR BLOCKAGE OF E-SELECTIN, A COMPONENT OF THE BONE MARROW ENDOTHELIAL NICHE, DELAYS HEMATOPOIETIC STEM CELL (HSC) TURN-OVER AND ENHANCES BONE MARROW CHEMORESISTANCE
Author: Winkler, G.

#170
DISSECTING THE COMPLEXITY OF THE OSTEOBLASTIC CELLS AND THEIR ROLE IN THE HSC NICHE
Author: Lymperi, S.

Session 13: Clinical Immunotherapy
Chairs: Mitchel Cairo & Geoff Hill
Speakers: Richard Boyd (Aust); Phil Darcy (Aus)
Abstracts:

#193
IMMUNE REGENERATION MEDIATED BY ENHANCED HEMATOPOIETIC STEM AND PROGENITOR CELL FUNCTION
Author: Dudakov, A.

#119
EX VIVO TRANSDUCTION AND EXPANSION OF CHIMERIC ANTIGEN RECEPTOR T CELLS GENERATES FUNCTIONAL CD8+ T CELLS WITH EFFECTOR AND CENTRAL MEMORY-LIKE PHENOTYPE
Author: Neeson, P.J.

#76
DENDRITIC CELL VACCINATION AS POST-REMISSION THERAPY FOR ACUTE MYELOID LEUKEMIA: RESULTS OF A PILOT PHASE I/II CLINICAL TRIAL
Author: Anguille, S.
12:15 - 1:00 pm Lunch
1:00 - 2:30 pm Concurrent Oral Presentation 4: Leukemic Stem Cell Biology
Chairs: Toshio Kitamura & Tim Hughes
Abstracts:

#6
BMI1 IS ESSENTIAL FOR LEUKEMIC REPROGRAMMING OF MYELOID PROGENITOR CELLS
Author: Yuan, J.

#56
LMO2 INDUCES PRECANCEROUS STEM CELLS IN A MOUSE MODEL OF T CELL LEUKEMIA
Author: McCormack, M.P.

#83
RAD51 AND XRCC3 POLYMORPHISMS: IMPACT ON THE RISK AND PROGNOSIS OF INV(16)/T(16;16)/CBFbMYH11(+) ACUTE MYELOID LEUKEMIA
Author: Liu, L.

#52
OVEREXPRESSION OF FULL LENGTH HOXA1 CAN DEVELOP INTO MYELOPROLIFERATIVE SYNDROMES AND LEUKEMIA WHEN THE NATURALLY OCCURRING TRUNCATED FORM OF HOXA1 IS INACTIVE
Author: Hendy, J.

#105
THE THROMBOPOIETIN/C-MPL PATHWAY IS REQUIRED IN AML1-ETO EXPRESSING HUMAN HEMATOPOIETIC CD34+ CELLS TO PROMOTE SELF-RENEWAL AND TO PREVENT APOPTOSIS
Author: Chou, F.C.

#132
THE VENT-LIKE HOMEOBOX GENE VENTX PROMOTES HUMAN MYELOID DEVELOPMENT AND IS HIGHLY EXPRESSED IN ACUTE MYELOID LEUKEMIA
Author: Rawat, V.P.S.

Concurrent Oral Presentation 5: MicroRNAs in Hemopoiesis and HSC Biology
Chairs: Thalia Papayannopoulou & Robert Oostendorp
Abstracts:

#89
MICROARRAY-BASED GENETIC SCREENS FOR MRNAS AND MICRORNAS THAT MODULATE HEMATOPOIETIC STEM/PROGENITOR CELL TRAITS
Author: Gerrits, A.

#161
HEMATOPOIETIC PROGENITOR CELL PROLIFERATION REQUIRES ERK
Author: Staser, K.W.

#137
THE CORE AUTOPHAGY REGULATOR ATG7 IS CRITICAL FOR ENGRAFTMENT ACTIVITY OF HEMATOPOIETIC STEM CELLS\
Author: Yamada, W.

#211
ACTIVIN SIGNALLING MODULATION IS CRITICAL FOR NORMAL HEMATOPOIESIS IN ADULT MOUSE
Author: Loveland, KL

#157
A DOMINANT ROLE OF PUMA OVER P21 IN HEMATOPOIETIC STEM CELLS AFTER EXPOSURE TO G-IRRADIATION
Author: Yu, H.

#179
HEMATOPOIETIC STEM AND PROGENITOR CELLS FAIL TO ACTIVATE A G1 CHECKPOINT IN RESPONSE TO DNA DAMAGE
Author: Ryan, M.

Concurrent Oral Presentation 6: HSC Microenvironment
Chairs: Kateri Moore & Shannon McKinney-Freeman
Abstracts:

#53
CILIARY NEUROTROPHIC FACTOR HAS SEX AND AGE-DEPENDENT EFFECTS ON B LYMPHOPOIESIS THAT ARE MEDIATED BY CHANGES IN THE BONE MARROW MICROENVIRONMENT
Author: White, K.E.

#186
LINKING THE BONE MARROW AND THYMUS STROMAL CELL NICHES IN IMMUNE REGENERATION ..
Author: Chidgey, A.P.

#194
HEMATOPOIETIC STEM CELLS ARE REGULATED THROUGH THE INTERACTION OF ALPHA9 BETA1 AND OSTEOPONTIN
Author: Grassinger, J.

#36
ENGRAFTMENT DEFECT OF CYTOKINE-ACTIVATED HUMAN CD34+ CELLS IS RELATED TO REDUCED ADHESION TO BONE MARROW (BM) ELEMENTS
Author: Kallinikou, K.

#7
THREE-DIMENSIONAL HYDROGEL-BASED CULTURES OF MESENCHYMAL STEM CELLS CLOSELY MIMIC THE IN VIVO HEMATOPOIETIC STEM CELL REGULATORY-NICHE
Author: Kale, V.P.

#43
TELOMERE DYSFUNCTION REGULATES HEMATOPOIETIC STEM CELL AGING VIA SYSTEMIC FACTORS
Author: Ju, Z.
2:30 - 3:00 pm Coffee Break
3:00 - 4:45 pm Session 14: Transplantation
Chair: David Curtis & Ngaire Elwood
Speakers: Kelli MacDonald (Aust); Silviu Itescu (Aust)
Abstracts:

#111
GSK-3BETA INHIBITION PROMOTES ENGRAFTMENT OF EX VIVO EXPANDED HEMATOPOIETIC STEM CELLS AND MODULATES GENE EXPRESSION
Author: Dr.Dolnikov

#74
STIMULATION OF INTESTINAL STEM CELLS WITH R-SPONDIN1 REGULATES SYSTEMIC GRAFT-VERSUS-HOST DISEASE
Author: Takashima, S.

#73
INVESTIGATING THE POTENTIAL OF PHARMACOCHEMICAL INHIBITION OF GSK3-BETA TO REDUCE THE BURDEN OF GVHD AFTER ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION
Author: Klamer, G.D.H.

Session 15: Therapeutic Drug Development
Chairs: Jim Palis & Andrew Roberts
Speakers: Tim Hughes (Aus); Grant McArthur (Aus)
Abstracts:

#81
INHIBITION OF AURORA-A KINASE ENHANCES THE CELL DEATH IN THE ARA-C-RESISTANT LEUKEMIA CELLS BY INDUCING MITOTIC CATASTROPHE
Author: Park, H.S.

#94
DELETION OF THE PROLINE-RICH REGION OF HOXB4 LEADS TO MYELOID LEUKEMIA IN MICE
Author: Cusan, M.

#116
REPRESSION OF GADD45A BY DNA METHYLATION IN ACUTE MYELOID LEUKAEMIA (AML)
Author: Perugini, M.
4:45 - 5:00 pm Closing Remarks
Chairs: Toshio Suda & David Scadden









 

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