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December 2010 ISEH Newsletter
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Connections in Hematology & Stem Cells is supported by a grant from

In the December 2010 issue

Annual Scientific Meeting
2012 Location Announced
2011 Scientific Meeting: Program Categories
2010 Annual Scientific Meeting Delivers: Perspective from Experimental Hematology Editors
Melbourne Experience Top-Notch for Young Investigators
Young Investigator Committee Formed

Society News
ISEH 2011 - Striving for "Fantastic Science", by David Scadden, President
Connect, Explore, Advance, by Kevin Baliozian, Executive Director
Have You Renewed Your Dues?

News from the Field
December Experimental Hematology, Vol.38 No.12

Member Profiles
Anskar Y. Leung, November Experimental Hematology author

Annual Scientific Meeting

2012 Location Announced

The ISEH 2012 Annual Scientific Meeting heads to Holland, and the Scientific Committee chair is Gerald de Haan, PhD, scientific director for ERIBA (European Institute on the Biology of Aging) and professor in the Department of Stem Cell Biology at the University Medical Center Groningen in the Netherlands. Dates and venue to come!

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2011 Annual Scientific Meeting: Program Categories
25-28 August, Westin Bayshore Hotel, Vancouver, Canada

For the fortieth year, ISEH will present ground-breaking research in hematology and stem cells featuring the leaders of the field in a small, focused venue for maximum interaction between colleagues.

Scientific program categories include:

  • Re-programming and epigenetics
  • HSC biology
  • Progenitor cell biology
  • Microenvironment
  • Aging
  • Transplantation/Gene therapy/Regenerative medicine
  • Leukemia
  • Lymphoma
  • Developmental biology
  • Tissue inflammation
  • Genomics

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2011 Scientific Program Committee
David Scadden, MD (chair) – United States
Gerald de Haan, PhD – Netherlands
Elaine Dzierzak, PhD – Netherlands
Tariq Enver, PhD – United Kingdom
Anthony Richard Green, PhD – United Kingdom
David Haylock, PhD – Australia
Peter Lansdorp, PhD, MD – Canada
Kelly McNagny, PhD – Canada
Susie Nilsson, PhD – Australia
Toshio Suda, MD – Japan

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2010 Annual Scientific Meeting Delivers: Perspective from Experimental Hematology Editors
15-18 September, Melbourne, Australia

The results are in and they are good. Nearly 97 percent of 2010 Annual Scientific Meeting attendees completing evaluations indicated they would recommend this meeting to others (122 of 126 responses). Respondents gave the meeting an overall rating of 4.16 on a 5-point scale. The Presidential Symposium: Stem Cell Niche Interactions was the most highly rated session, followed closely by the Young Investigators Career Panel Discussion.

Many completing the meeting evaluation took the time to write comments, including:

  • Fantastic science, top to bottom. New investigator sessions were superb.
  • Good scientific program. Opportunity to meet with colleagues.
  • Very friendly; lots of unpublished data presented.
  • The quality of the science and the invited speakers was excellent and the food was awesome.
  • Good venue, great networking opportunities; good scientific content, well-organized.
  • It was not too big, so I had the chance to interact with colleagues from other labs.
  • The environment, organization and opportunity to meet experts in the field.
  • The combination of a really good scientific program in a fantastic venue and the closeness/intimacy for networking of a relatively small meeting make the ISEH one of my favorite meetings.
  • Excellent science, excellent scientists with whom to interact.

Additionally, some of the editors of Experimental Hematology provided brief wrap-ups of the meeting as follows.

"The absolute highlight of the meeting for me was the session with new investigator presentations. I was part of the judging panel and all four Ph.D. and all four post-doc talks ended up with excellent marks. Eight of eight excellent talks made this the true highlight for me. Other highlights for me were the talk by Elaine Dzierzak with the most beautiful pictures of AGM haematopoietic clusters, the talk by Xiaoying Bai characterizing a new mutant that can rescue the zebrafish moonshine mutant and suggested that transcriptional functions of cohesion subunits are important, and the talk by Paul Kincade with his new insights into stem cell heterogeneity and the potential impact of infections."
Bertie Göttgens (Associate Editor)

"The Melbourne meeting will be remembered as a collegial gathering of international scientists in an outstanding venue in one of the most beautiful cities in the world. On Thursday morning, hundreds of colleagues attended the developmental hemopoiesis session that was held in honor of the late Greg Johnson. Dr. Chung Li provided an overview of Dr. Johnson’s career highlighting the contributions he had made to developmental hematopoiesis and stem cell biology. Dr. Georges Lacaud discussed the latest information on the hemogenic endothelial to hematopoietic transition in cultured murine embryonic stem cells. Dr. Elaine Dzierzak revealed new information on techniques that have permitted quantitating the hematopoietic clusters that emerge from the aortic endothelium during the phase of hematopoietic stem cell emergence in the embryo. Dr. Paul Gadue provided an overview for the molecular events that regulate emergence of the first hematopoietic cells from human embryonic stem cells. In sum, this was an outstanding session with cutting edge insights provided by world-class scientists. I would hope Dr. Greg Johnson would have agreed."
Merv Yoder (Associate Editor)

"I truly enjoyed Bertie Göttgens’ talk where he beautifully provided insight into transcriptional networks regulating blood cell development. It was an exemplary case of where biology, genomics, bioinformatics and modeling meet. The meeting was very strong in showing advances in our understanding of the microenvironment. The interaction between macrophages, osteoblasts and LT-HSC was beautifully documented by a talk from Ingrid Winkler (#197). It becomes increasingly clear that hematopoiesis is under control from neuronal input (Paul Frenette's talk) and that diabetes may impact stem cells (David Scadden). This just shows how cross talk between different systems/organs also is relevant for the hematopoietic system. As always, the junior investigator sessions were excellent. The ISEH remains a great meeting for young scientists."
Gerald de Haan (Associate Editor)

"Another stellar meeting – just the right size to allow meaningful interactions, superb plenary talks, a great venue and, perhaps for me most importantly, a huge contingent of young investigators/trainees. The meeting started out on a very high note with a tour de force Metcalf lecture given by Ihor Lemischka introduced by none other than Don Metcalf himself. The posters were well attended and showed that the right number of people, good science and, let’s face it, some nice Australian beer and wine made for stimulating interactions. Another element that made the meeting special was the huge effort from the local organizing committee led by Susie Nilsson and David Haylock. One had a sense that not a single detail from science to the social side was overlooked. The bar has been set very high indeed for next year’s meeting in Vancouver!"
Keith Humphries (Incoming Editor-in-Chief)

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Young Investigators

Melbourne Experience Top-Notch for Young Investigators

ISEH continues to provide opportunities for young scientists to grow in their careers, including facilitating relationships with established ISEH scientists. At the Melbourne meeting, there were several activities planned for young scientists, and the New Investigators Session featured presentations by four Ph.D. students and four post-docs:

  • S.L. Ellis, Peter MacCallum Cancer Centre, East Melbourne, Australia
  • Rebecca Neaves, Australian Stem Cell Centre, Clayton, Australia
  • K. Klauke, University Medical Centre Groningen, Groningen, Netherlands
  • T.C. Luis, Leiden University Medical Center, Leiden, Netherlands
  • F. Ferraro, Harvard Stem Cell Institute, Massachusetts General Hospital, CRM, Boston, United States of America
  • D. Lucas-Alcaraz, Mount Sinai School of Medicine, New York, USA
  • G.L. Swiers, University of Oxford, Oxford, United Kingdom
  • E.S. Yung, BC Cancer Agency, Vancouver, Canada

This session provides exposure for the work of these young scientists and gives them access to those further along in their careers. The opportunity to present their work in such an important venue makes quite an impact for these young scientists. And, in fact, it is equally impactful for the senior scientists to listen to those up and coming.

"During the meeting it became clear to me that the expectations for the Young Investigator Session were particularly high, which made me more nervous than usual for a presentation,” explains Karin Klauke. "However, I got many positive responses on my presentation from other scientists in the field. The discussions with the scientists that approached me after the presentation were very constructive. Some scientists even proposed starting collaborations to examine our findings in more depth and to explore whether the method we used may have other interesting applications as well.

Besides their presentations during the session, the young investigators took advantage of the many opportunities afforded them throughout the meeting.

"I enjoyed all of the sessions I attended,” reports Sarah Ellis. "The two highlights for me looking back were the early morning careers session and the annual dinner. The former provided valuable insight into what careers are out there for scientists and the pros and cons of each career choice. The conference dinner was most enjoyable as I sat at a table with few people I knew. Discovering their great variety in career paths and chatting in a relaxed atmosphere was enlightening.

All in all, facilitating exchange between new and more established scientists is a win for both sides of the equation.

"My goals for the ISEH meeting were to discuss my results with leaders in the field and to obtain a complete overview of ongoing and forthcoming research and new innovative ideas. I achieved these goals during the ISEH 2010 meeting,” Klauke concludes. "Discussing research during congresses is an important aspect of doing science. ISEH scheduled many occasions for this in their program, which I really enjoyed.

"My goals for attending were accomplished,” Ellis adds. "I would have liked to meet some of the more senior scientists in my research field to discuss current and future studies in a more relaxed setting. Some attendees did approach me after the session and congratulated me on giving a good talk. I would really have welcomed some interactive discussions on future directions and thoughts on whether or not my research was cutting-edge."

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Young Investigators Committee Formed

Building on the momentum of young investigator activity at the 2010 Annual Scientific Meeting and supporting the ISEH mission statement, the ISEH Board of Directors established the Young Investigators Committee. This committee is responsible for representing the needs and ensuring the development of junior investigators within ISEH.

Committee members are:
Teresa Bowman (USA)
Marie-Dominique Filippi (USA)
Jochen Grassinger (Germany)
Zhenyu Ju (China)
Isao Kobayashi (Japan)
Florian Kuchenbauer (Germany)
Shannon McKinney-Freeman (USA)

Watch the ISEH website for news from this new committee.

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Society News

ISEH 2011 - Striving for "Fantastic Science"

By David Scadden, MD
ISEH President

One attendee from the Melbourne meeting wrote this in his or her meeting evaluation:

"Fantastic science, top to bottom.” That sums it up, doesn’t it? And, I believe it validates that we are effectively meeting the mandate of our mission statement: The mission of ISEH is to promote the scientific knowledge and clinical application of basic hematology, immunology, stem cell research, cell and gene therapy, and all related aspects through research, publications, discussion, support of young investigators and organization of scientific meetings.

With the objective of "fantastic science” as our guide, the ISEH Board of Directors can lead the Society through the opportunities and challenges that present themselves throughout any given year. And, we can do it with confidence that we have the best interests of our members in mind.

The Society continues to operate from a position of financial strength due to proper management and success of our yearly meetings. Based on the evaluations gathered following Melbourne, we continue to be "in tune” with member needs relating to education and networking.

But, we want to do more. We’ve taken very significant steps to build upon that once-a-year experience at a scientific meeting. To that effort, we have redesigned the ISEH website to be a comprehensive vehicle for content distribution with you, the member, at the center. Looking for the latest research published in Experimental Hematology? It’s available through www.iseh.org. Looking for an expert in hematopoietic stem cells? Search the term on the website. Want some input from your peers? Use a website forum to pose a question. The goal of the site is to make relevant information available to you when and how you want it. By doing so, we continue to build the ISEH community.

Another way we are working to build the community is by listening to you. Tell us what you want from the Society and at your Annual Scientific Meeting. Tell us where you would like a meeting to be held and why – be sure to describe for us the local support available to make this location successful. We have locations booked through 2012, but invite your input for 2013 and beyond.

You have entrusted your elected board with shaping ISEH in 2011 and beyond. On behalf of the full board listed below, thank you for that trust and feel free to contact any of us at any time with your thoughts.

Your 2011 ISEH Board of Directors:
President: David Scadden, MD (USA)
President-Elect: Gerald de Haan, PhD (Holland)
Vice President: Elaine Dzierzak, PhD (The Netherlands)
Treasurer: Tao Cheng, MD (China)
Editor: R. Keith Humphries, MD, PhD (Canada)
Past President: Toshio Suda, MD (Japan)

Directors:
Mitchell Cairo, MD (USA)
Margaret Goodell, PhD (USA)
Toshio Kitamura, PhD (Japan)
Hanna Mikkola, MD, PhD (USA)
Susie Nilsson, PhD (Australia)
Emmanuelle Passegué, PhD (USA)
Louise Purton, PhD (Australia)
Timm Schroeder, PhD (Germany)
David Traver, PhD (USA)

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Connect. Explore. Advance.

By Kevin Baliozian
ISEH Executive Director

Connect. Explore. Advance. These words are prominently placed at the top of every page of our newly redesigned ISEH website for a very important reason – they succinctly describe the basis of, and provide direction for, the Society for Hematology and Stem Cells.

Connect. Collaboration is inherent in the life of a scientist, and membership in ISEH affords you additional opportunities to easily interact with other leaders in our field.

Explore. Where would science be without the curiosity that is a driving factor in your work? At ISEH, you can easily share your discoveries and also learn from the exploration of others.

Advance. Each of you works daily to move your research forward for the good of all. By sharing freely with one another, you can likely achieve your goals more efficiently.

Your ISEH Board of Directors and other volunteer leaders, as well as your professional staff team, take very seriously the Society’s role in promoting the knowledge and clinical application of this scientific specialty. Wherever you are in your career path – from the most experienced to those just beginning the journey – you can rely upon ISEH to be at the forefront, helping you stay focused and drive to great achievement.

Let us know how we can help.

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Have You Renewed Your Dues?

Renew your ISEH membership for 2011 so that you can continue to connect with more than 800 researchers in your field, explore the field together and advance your profession.

Your membership benefits include:

  • NEW Enhanced website! You are now connected through instant messaging to members who are online, posting to colleagues’ walls, reading articles on featured membership profiles and responding to discussion forums.
  • A personal subscription and exclusive full-text online access to the journal, ExperimentalHematology, including supplements and abstracts for ISEH-supported meetings.
  • No manuscript submission fee for Experimental Hematology, the official Society journal. This offer is valid for corresponding authors of submitted manuscripts.
  • ISEH Connections in Hematology & Stem Cells, your ISEH electronic newsletter, the exclusive source for Society, member and industry news.
  • Reduced registration fees at the ISEH Annual Scientific Meeting and other selected educational events organized or supported by ISEH.
  • Eligibility for ISEH awards and travel grants.
  • An opportunity to serve on ISEH Committees and the Board of Directors.

Be sure to also update your member profile, so that members and staff know how to reach you. It is easy to do with the new web platform.

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News from the Field

Experimental Hematology keeps you up-to-date on the latest research emerging in our field. Scan the current issue contents below, clicking through to articles of interest to you. All issues are available to you on the Experimental Hematology website

December 2010, Vol. 38 No. 12

Review Article:
Serum microRNAs as a novel class of biomarkers: a comprehensive review of the literature
Nathalie Schöler, Christian Langer, Hartmut Döhner, Christian Buske, Florian Kuchenbauer

Clinical Investigation:
Evidence of mobilization of pluripotent stem cells into peripheral blood of patients with myocardial ischemia
Ahmed Abdel-Latif, Ewa K. Zuba-Surma, Khaled M. Ziada, Magdalena Kucia, Donald A. Cohen, Alan M. Kaplan, Gary Van Zant, Samy Selim, Susan S. Smyth, Mariusz Z. Ratajczak

Cytokines:
Cdc25A-driven proliferation regulates CD62L levels and lymphocyte movement in response to interleukin-7
Christina Kittipatarin, Wenqing Li, Scott K. Durum, Annette R. Khaled

HIV-1 infection inhibits cytokine production in human thymic macrophages
Tomasz Rozmyslowicz, Samuel L. Murphy, Dareus O. Conover, Glen N. Gaulton

Hematological Malignancies:
Dipeptidyl peptidase 2 apoptosis assay determines the B-cell activation stage and predicts prognosis in chronic lymphocytic leukemia
Alexey V. Danilov, Olga V. Danilova, Jennifer R. Brown, Arthur Rabinowitz, Andreas K. Klein, Brigitte T. Huber

Inhibition of the redox function of APE1/Ref-1 in myeloid leukemia cell lines results in a hypersensitive response to retinoic acid-induced differentiation and apoptosis
Melissa L. Fishel, E. Scott Colvin, Meihua Luo, Mark R. Kelley, Kent A. Robertson

MYEOV is a prognostic factor in multiple myeloma
Jerome Moreaux, Dirk Hose, Amélie Bonnefond, Thierry Reme, Nicolas Robert, Hartmut Goldschmidt, Bernard Klein

NF-κB mediates aberrant activation of HIF-1 in malignant lymphoma
Qiao Qiao, Yumi Nozaki, Kumi Sakoe, Norio Komatsu, Keita Kirito

Naturally occurring CD4+ CD25+ FOXP3+ T-regulatory cells are increased in chronic myeloid leukemia patients not in complete cytogenetic remission and can be immunosuppressive
Jose M. Rojas, Lihui Wang, Sally Owen, Katy Knight, Sarah J. Watmough, Richard E. Clark

Chronic lymphoid leukemia cells are highly sensitive to the combination of prednisolone and daunorubicin, but much less to doxorubicin or epirubicin
Henriette Skribek, Rita Otvos, Emilie Flaberg, Noemi Nagy, Laszlo Markasz, Staffan Eksborg, Tamas Masszi, Andras Kozma, Emma Adam, Attila Miseta, Eva Klein, Laszlo Szekely

Stem Cell Biology:
Acquisition of G0 state by CD34-positive cord blood cells after bone marrow transplantation
Haruko Shima, Keiyo Takubo, Naoko Tago, Hiroko Iwasaki, Fumio Arai, Takao Takahashi, Toshio Suda

Stem Cell Transplantation:
Reduced-intensity conditioning with Fludarabin, oral Busulfan, and thymoglobulin allows long-term disease control and low transplant-related mortality in patients with hematological malignancies
Didier Blaise, Laure Farnault, Catherine Faucher, Nicholas Marchetti, Sabine Fürst, Jean El Cheikh, Patrick Ladaique, Norbert Vey, Reda Bouabdallah, Anne-Marie Stoppa, Claude Lemarie, Boris Calmels, Thomas Prebet, Luca Castagna, Christian Chabannon, Mohamad Mohty, Benjamin Esterni

Intrinsic and extrinsic effects of mafG deficiency on hematopoietic recovery following bone marrow transplant
Xiao-Miao Li, Zhongbo Hu, Abu-Bakr Zafar, Marda L. Jorgensen, Jorg Bungert, William Slayton

Chimerism studies with quantitative real-time PCR in stem cell recipients with acute myeloid leukemia
Bettina Wiedemann, Evgeny Klyuchnikov, Nicolaus Kröger, Tatjana Zabelina, Tanja Stahl, Silke Zeschke, Anita Badbaran, Francis Ayuk, Haefaa Alchalby, Christine Wolschke, Carsten Bokemeyer, Boris Fehse, Axel Rolf Zander, Ulrike Bacher
news

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Member Profile...

ISEH, comprised of industry leaders in hematology, immunology, stem cell research, and cell and gene therapy, connects members worldwide for the opportunity to advance scientific knowledge. Each issue of Connections in Hematology & Stem Cells will introduce you to a few of those members. This issue, meet Anskar Y.H. Leung.

Anskar Yu-Hung Leung, November Experimental Hematology author
Associate Professor, Department of Medicine
The University of Hong Kong

Dr. Anskar Yu-Hung Leung is a specialist in haematology and haematological oncology. His article in the November 2010 issue of Experimental Hematology, "Role of a novel zebrafish nup98 during embryonic development,” with fellow authors Tsz-Kan Fung, Martin I.S. Chung and Raymond Liang, has been met with great interest.

According to the paper’s objectives section, "the nucleoporin NUP98 is a component of the nuclear pore complex that regulates nucleocytoplasmic trafficking. It has been characterized in acute myeloid leukemia as a fusion partner during chromosomal translocation. In this study, we identified a zebrafish nup98 gene and examined its role in embryonic development.

The results found that "a novel zebrafish nup98 was identified and it serves a role in nucleocytoplasmic trafficking similar to human NUP98. During development, it modulates hematopoietic stem cell and early myeloid development and maintains the integrity of cranial vasculature in the developing central nervous system.

"The work on zebrafish nup98 has provided us with grounds to develop a model whereby the pathogenetic role of human leukemia fusion gene in zebrafish can be characterized in zebrafish,” Dr. Leung reports. "Patients with acute myeloid leukemia carrying NUP98-HOXA9 have a very grave prognosis with conventional treatment. The model which we are going to develop will enable us to screen novel agents targeting this particular leukemia type.

Working with zebrafish for his science was a logical progression for this fish hobbyist.

"Keeping an aquarium as a hobby has always been part of my life since I was a kid,” he shares. "As a clinical hematologist, I manage patients with hematological malignancies in my practice. When I learned a few years ago that zebrafish can be useful in modeling human blood diseases, it instantly became my focus of research.

Dr. Leung is a widely published author. In addition to the Experimental Hematology piece mentioned above, his 2010 manuscripts include:

  • A DEAB-sensitive aldehyde dehydrogenase regulates hematopoietic stem and progenitor cells development during primitive hematopoiesis in zebrafish embryos. Leukemia.
  • Differential NOD/SCID mouse engraftment of peripheral blood CD34(+) cells and JAK2V617F clones from patients with myeloproliferative neoplasms. Leuk Res.
  • Successful engraftment by leukemia initiating cells in adult acute lymphoblastic leukemia after direct intrahepatic injection into unconditioned newborn NOD/SCID mice. Exp Hematol.
  • FLT3/internal tandem duplication subclones in acute myeloid leukemia differ in their engraftment potential in NOD/SCID mice. Leuk Res.
  • Haematopoietic stem cell transplantation: current concepts and novel therapeutic strategies. Br Med Bull.
  • Occult autologous haematopoietic regeneration without disease relapse following myeloablative allogeneic haematopoietic SCT for lymphomas. Bone Marrow Transplant.
  • Mediastinal cryptococcosis masquerading as therapy-refractory lymphoma. Ann Hematol.
  • CD20 expression in natural killer T cell lymphoma. Histopathology.
  • Metabolic activity measured by F-18 FDG PET in natural killer-cell lymphoma compared to aggressive B- and T-cell lymphomas. Clin Nucl Med.
  • Spontaneous central venous catheter fracture: relevance of the pinch-off sign. J Hosp Med.
  • Sweet Syndrome due to Myelodysplastic Syndrome: Possible Therapeutic Role of Intravenous Immunoglobulin in Addition to Standard Treatment. Adv Hematol.
  • T-cell large granular lymphocyte leukemia: an Asian perspective. Ann Hematol.

Dr. Leung relates some challenges facing him in his professional life today.

"With conventional chemotherapy and even hematopoietic stem cell transplantation, the treatment outcome of most patients with acute myeloid leukemia is not satisfactory,” Dr. Leung states. "As a practicing hematologist, I feel the need and urgency to look for novel treatment for these diseases. Until recently, biomedical research has not been the focus of government policy in Hong Kong and local research has been limited by the availability of resources. Fortunately, the condition may improve as the public awareness of stem cell research has increased locally and we all expect more resources to be invested from government.

Another challenge facing this scientist is on the home front where he is instructing his sons, ages eight and 10, to clean the home aquarium.

"I believed the trait of keeping up the aquarium should be inherited, but it isn’t,” he sadly concludes."

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