January 2014

About ISEH

The mission of ISEH is to promote the scientific knowledge and clinical application of basic hematology, immunology, stem cell research, cell and gene therapy, and all related aspects through research, publications, discussion, support of young investigators and organization of scientific meetings.

In this Issue

New Investigator Digest

News from the Field

Member Profile

Society News

Don't Miss These Meetings

Experimental Hematology


Members' Corner

Interested in reaching your target audience? For only $500 you can place a banner advertisement in ISEH Connections Newsletter. Contact ISEH at info@iseh.org

President’s Message: Focus on membership

Why are we members of ISEH? Why are we members of any scientific society? As we call for membership renewal and launch our new membership drive, it is worth reflecting on this question. The Geological Society of London, one of the oldest scientific societies, was founded in 1807 with the goal of "Making geologists acquainted with each other, stimulating their zeal, … facilitating the communication of new facts and ascertaining what is known in their science and what remains to be discovered".

This mission statement could equally apply to ISEH today. Indeed, ISEH was founded in 1950 to promote basic and translational hematology research through publications and annual meetings- this remains our raison d’être. One strategy we have recently adopted is to cultivate the "zeal” of our trainees through many special opportunities for junior investigators.

There are other societies that may compete for our attention (ASH and ISSCR, for example), but these are much more diverse than ISEH, and the fellowship and personal interactions that most members find so satisfying at ISEH meetings is not replicated at these larger conferences. ISEH is really a unique forum that promotes your interests most effectively.

So, why do we join and remain members? --largely because we find at ISEH other investigators with similar interests. Being a member shows our support of the field, and in turn our membership supports the growth and stability of our field, which has never been more important.

With this in mind, please renew your membership and urge your colleagues to renew or join.

Best wishes,

Margaret (Peggy) Goodell
ISEH President

New Investigator Digest

Why belong to ISEH? New Investigators share their experiences

Meet the New Investigator Committee members and their top reasons for being involved with ISEH. "I'm a member of ISEH because I feel like my voice is heard." Read more on website

News From the Field

News roundup: December 2013

A collection of industry, policy, government and other hot news from the field of hematology and stem cell.

OMP-54F28 (Fzd8-Fc) Program Reaches Dose Escalation Milestone in Phase 1a Clinical Trial; Triggers $15 Million Payment From Bayer Pharma AG

$100 Million Gift Launches Sanford Stem Cell Clinical Center

ViGene Biosciences Introduces World's Largest Collection of Pre-Made Human Full-Length cDNA ORF and miRNA Adenoviruses

Actinium Pharmaceuticals Announces Plans for Iomab™-B Phase III Pivotal Trial Following Meeting with FDA

Americord Advances Method of Obtaining Mesenchymal Stem Cells from the Placenta

Polaris Group Announces Treatment of First Patient in Phase II Study of ADI-PEG 20 in Acute Myeloid Leukemia

The Leukemia & Lymphoma Society Applauds FDA's Approval of Gazyva® as First-Line Treatment for Patients with Chronic Lymphocytic Leukemia

Kiadis Pharma Provides Positive Update on its Phase II Clinical Program with Blood Cancer Treatment ATIR™

New HHS Rule: Blood Stem Cells Aren't for Sale

ERYTECH Announces Positive DSMB Review of its Phase IIb Study in Acute Myeloid Leukemia


Member Profile

Meet Anna E. Beaudin - New Investigator Award
Winner 2013

Anna Beaudin has spent three years studying hematology and stem cells as a Postdoctoral Fellow in the Department of Biomolecular Engineering at UC Santa Cruz. She has been an ISEH member for two years, beginning in 2011 when she submitted an abstract and made a short presentation in Vancouver. Her areas of expertise are hematopoiesis, stem cells, development, neural development, nutritional science, and metabolism. Read more on website

Society News

New task force on a mission to generate membership

The new Membership & Marketing Task Force, headed up by Hanna Mikkola and David Traver, has some big plans to help grow the ISEH membership in 2014.

The new task force, with its truly international contingency, is beginning a campaign to contact lapsed members from years past, and personally reaching out to other colleagues in the field to encourage new membership and involvement with our growing organization.

With the kickoff of the 2014 renewal season this past October, the introduction of the new 2-year membership option has also generated some excitement among our membership. Now it’s time for us to spread the word about ISEH and encourage our friends and colleagues to get involved by renewing their memberships or joining for the first time.

What can you do to help? Tell us why you’re an ISEH member.

Was it a mentor who told you about ISEH? Did you first join to attend a meeting? What makes you renew year after year? ISEH would like to know. We’d like to show our potential new members why our membership is so dedicated to ISEH. Email your thoughts and stories about ISEH to mdaniels@iseh.org by 30 January, 2014.

2013 webinar series concludes with lecture on xenograft models

On December 16th 2013, ISEH had the privilege to host the webinar of Dr. Gwenn Danet-Desnoyers entitled "Xenograft models of human hematopoiesis and leukemia". Dr. Danet-Desnoyers is the Director of the Stem Cell and Xenograft Core and an adjunct Associate Professor at the University of Pennsylvania School of Medicine. He has help organized one of the most comprehensive resource lab in the US with a large tissue bank and a variety of xenograft models to accelerate the treatment of leukemic patients. Read more on website

View all of the 2013 webinars (members only)

Don't Miss These Meetings

Queensland and California to host notable March sessions

5th New Directions in Leukaemia Research (NDLR)
Sunshine Coast, Queensland, Australia
March 30th to April 2nd 2014

4th International Conference on Stem Cell Engineering
Coronado, CA, United States
March 16-19, 2014

Read more on website

Experimental Hematology

Experimental Hematology offers fast publication time

Experimental Hematology offers one of the fastest publication times in the field
Read more on website

Inside the November and December 2013 issues

Take a quick tour of the November and December issues and get a feel for the publication's cutting-edge scientific content. Read the full issues online.

In this Issue – November 2013

Heterospecific cell hybrids, a powerful system for the study of globin gene switching
See Chang et al., pages 967–979.

Harnessing redox homeostasis for enhanced hematologic recovery after hematopoietic stem cell transplantation
See An et al., pages 944–956..

Double umbilical cord blood transplantation for hematological malignancies
See Wallet et al., pages 924–933.

In this Issue – December 2013

Inhibition of GSK-3β promotes naive T cell expansion in bone marrow reconstituted mice.
See Shen etal., pages 1016–1027.

Immunologic pathomechanism of Hodgkin’s lymphoma
See Jona etal., pages 995–1004.

Tenascin C regulates hemopoiesis within alternate niches
See Ellis etal., pages 1050–1061.

NEW! Experimental Hematology now accepts brief communications

Experimental Hematology welcomes articles that can be reported in a shorter format. Brief communications are intended to allow publication of highly significant findings reported concisely, and not of incomplete or preliminary data. As with regular submissions, brief communications are expected to provide mechanistic insights, elucidate novel disease biology or approaches to therapy. Click here to learn more.

Regular and fast-track submissions are encouraged

The publishing team seeks manuscripts, reviews, perspectives and letters to the editor describing basic in vitro and in vivo research centered on normal and malignant hematopoiesis, as well as non-malignant hematologic diseases. Read more on website


Editors Pick: Worldwide postdoc and career opportunities

Endowed Chair in Pediatric and Hematology and Oncology/Professor (Richmond, VA)

Chief Medical Officer (Morris Plains, NJ)

Director, Clinical Immunogenetics Laboratory (Seattle, WA)

Post-doctoral fellow-Stem Cell biologist (Chicago, IL)

Postdoctoral Fellow - Mammalian Hematopoietic and Erythroid Development (New York, NY)

Postdoc Fellow in Hematopoietic Stem Cell Research (Lund, Sweden)

Postdoctoral position available immediately in Stem Cells and Bioengineering (Brisbane, Australia)

Members' Corner

ISEH applauds members' outstanding accomplishments

Congratulations to:

Leonard Zon for the publication in:

a) Nat Cell Biol of the manuscript entitled: "A network of epigenetic regulators guides developmental haematopoiesis in vivo".Nat Cell Biol. 2013 Dec;15(12):1516-25.

b) Cell of the paper entitled: "A zebrafish embryo culture system defines factors that promote vertebrate myogenesis across species".Cell.2013 Nov 7;155(4):909-21.

Drs. Emanuele Azzoni and Marella De Bruijn for the publication of their manuscript inCell Stem Cell entitled: "Lymphomyeloid contribution of an immune-restricted progenitor emerging prior to definitive hematopoietic stem cells".Cell Stem Cell 2013 Nov 7;13(5):535–548.

Drs. David Scadden and Constanze Bonifer for the publication of their manuscript in Cancer Cell entitled: "Sox4 is a key oncogenic target in C/EBPα mutant acute myeloid leukemia".Cancer Cell. 2013 Nov 11;24(5):575-88.

ISEH is very proud of our members' accomplishments. Please send any news that you would like to share with your colleagues to exphem@iseh.org.