August/September 2013

About ISEH

The mission of ISEH is to promote the scientific knowledge and clinical application of basic hematology, immunology, stem cell research, cell and gene therapy, and all related aspects through research, publications, discussion, support of young investigators and organization of scientific meetings.

Table of Contents

Annual Meeting News
News from the Field
Member Profile
Society News
Don't Miss These Meetings
Experimental Hematology
Members' Corner

Editor's Note: Carolina Abramovich, PhD

What a great meeting! Following the long tradition of ISEH Annual Meetings, the 42nd Annual meeting in Vienna fused a diverse, dynamic and engaging conference program with unique networking and educational opportunities among leading researchers and new investigators of the experimental hematology community.

The meeting officially opened on Thursday, August 22 at the
Imperial Riding School Renaissance Vienna Hotel. The 2013 Program Committee packed the four day meeting schedule with an admirable array of invited sessions, organized and presented by leading researchers on cutting-edge topics. Sessions were complimented by poster and podium presentations by rising stars in the field.

Stay tuned for a full report of the meeting in the October issue of Connections.

Annual Meeting News

ISEH 42nd Annual Scientific Meeting: Unparalleled Science Presented

This year’s meeting in Vienna, Austria boasted more than 375 attendees from leading research labs and facilities around the world. The meeting started with a dynamic presentation, "Making and Improving the Function of Adult Blood Stem Cells" by Dr. Leonard Zon, (pictured, left) Howard Hughes Medical Institute, Division of Hematology/Oncology, as he received the prestigious Donald Metcalf Award.

Throughout the meeting, attendees took the opportunity to network each evening while viewing around 200 posters.

As a fitting end to the meeting, Dr. Hanna Mikkola, University of California – Los Angeles (below, with ISEH president Elaine Dzierzak), was presented the McCulloch and Till Award for her advancement of the hematology field as a junior scientist. Mikkola said, "I am extremely honored and humbled to receive this award.”

The New Investigator Committee kept everyone informed throughout the meeting by tweeting highlights at #ISEH2013 – Make sure you are following @ISEHSociety to keep up with the latest information.

ISEH wants to thank our exhibitors, sponsors and grant supporters this year!

News From the Field

News roundup: August 2013

A collection of industry, policy, government and other hot news from the field of hematology and stem cell.

Spanish scientists successfully generate 'artificial bones' from umbilical cord stem cells

Stem Cell Agency’s Board Approves $70 Million Plan to Develop Innovative Alpha Clinics
Scéil™: a new offering for the general public to turn adult cells into stem cells and store them

BioLineRx Enrolls First Patient in Phase 2 Clinical Trial for BL-8040, for Treatment of Leukemia

New sickle cell anemia therapy advances to phase II clinical trials

FDA puts Cell Therapeutics blood cancer drug on hold after death

MEI Pharma Initiates Phase II Clinical Trial of Pracinostat and Vidaza® in Frontline Myelodysplastic Syndrome

Market Access Granted in Italy for Aggressive non-Hodgkin Lymphoma Treatment, PIXUVRI® (pixantrone)

FDA grants Roche’s obinutuzumab (GA101) Priority Review for previously untreated chronic lymphocytic leukemia (CLL)

Celgene Will Discontinue Phase III ORIGIN® Trial in Previously Untreated Elderly Patients with B-Cell Chronic Lymphocytic Leukemia

Roche's obinutuzumab (GA101) delayed disease progression longer than MabThera/Rituxan in people with one of the most common forms of blood cancer

Member Profile

"Doing something for the people who need you most" - Meet Dr. Battacharyya

Dr. G. S.Bhattacharyyais a consultant at the Chittaranjan National Cancer Institute in Kolkata, India. He is also in charge of the Department of Medical Oncology of the Fortis Hospital, in Anandapur, Kolkata, as well as of the Department of Medical Oncology in the AMRI Hospital of Dhakuria, Kolkata. Dr. Bhattacharyya is a member of the European Society for Medical Oncology (ESMO), the Breast International Group (BIG), the IASLC Committee, and the incoming president of the Indian Society for Medical and Pediatric Oncology (ISMPO). Read more on website

Society News

ISEH announces Board of Directors election results for 2013

ISEH closed its 2013 Board of Director’s election 12 August. Nearly 115 members (or 19 percent of the membership) voted. The results were extremely close, which speaks to the high quality of candidates on the ballot. Your newly elected Board members include:
Vice President:David Traver
Directors: America: Trista North
Directors: Europe: Conny Bonifer
Directors: Pacific Rim: Koichi Akashi
Read more on website.

Register for the niche debate webinar

23 September 2013 - "HSC bone marrow niche: is the endosteal or vascular niche the main site for hematopoiesis?"
Watch presenters David Scadden and Paul Frenette debate their views on the topic. Andreas Trumpp to moderate the discussion. Free to ISEH Members! Register and read more on website

ISEH Finance Committee seeks investment volunteer

ISEH is undergoing an RFP process to find a financial investment partner. The ISEH Finance Committee is seeking an ISEH member to assist in conducting approximately 5 interviews of potential investment firms. Due to the geographic composition of the committee an individual within North America who is familiar with the United States financial system is needed. Read more on website

Don't Miss These Meetings

Cancer genomics and human development highlight November offerings

EMBL Conference-Cancer Genomics
Sunday 3 November - Tuesday 5 November 2013 - EMBL Heidelberg, Germany

The Stem Cell Society Singapore (SCSS) Symposium 2013: "Early Human Development & Fetal-Maternal Medicine"
18-19th November 2013 - Biopolis, Singapore
Read more on website

Experimental Hematology

Experimental Hematology offers fast publication time

Experimental Hematology offers one of the fastest publication times in the field
Read more on website

Inside the July and August 2013 issues

Take a quick tour of the March and April issues and get a feel for the publication's cutting-edge scientific content. Read the full issues online.

In this Issue – July 2013

Single-cell Raman spectroscopy demonstrates mechanochemical differences between normal, sickle, and cord red blood cells
Liu et al. pages 656–661.

Involvement of the aldehyde dehydrogenase 1 family member A2 in AraC resistance
Kawasoe et al., pages 597–603.

New insights into the biology of endothelial selectins in hematopoietic stem/progenitor cell migration
Nabors et al., pages 588–596.

Telomere shortening in Philadelphia-negative chronic myeloproliferative neoplasms
Ruella et al., pages 627–634.

In this Issue – August 2013

Engraftable CD34+cells from human embryonic stem cells

Kim et al., pages 749–758.

G6PD deficiency in a Zebrafish model
Patrinostro et al., pages 697710.

Myelodysplastic syndrome and the genomic instability hypothesis
Zhou et al., pages 665–674.

Efficient platelet production from human pluripotent stem cell–derived megakaryocytes using a two-directional flow bioreactor
Nakagawa et al., pages 742–748.

Regular and fast-track submissions are encouraged

The publishing team seeks manuscripts, reviews, perspectives and letters to the editor describing basic in vitro and in vivo research centered on normal and malignant hematopoiesis, as well as non-malignant hematologic diseases. Read more on website


Leukemia & Lymphoma Society Invites Letters of Intent for New Idea Award

The Leukemia & Lymphoma Society is inviting Letters of Intent for the second round of its New Idea Award, a grant program intended to develop safer and more effective treatment paradigms for patients with hematological malignancies. Specifically, the program is offering concept grants in support of academic researchers with innovative therapy ideas that are substantially different from current standard treatments and may advance to clinical testing in the short-term. Up to eight grants of up to $100,000 will be awarded. Visit the LLS Web site for complete guidelines and application information.

Editors Pick: Worldwide Career opportunities available

Postdoctoral Researcher (Bronx, New York)

Postdoctoral Fellow in Cancer Stem Cell Biology (Montreal, Canada)

Postdoc position in computational analysis of genome-wide data of normal and malignant blood cells (Copenhagen, Denmark)

Hematology/Oncology Faculty (Madison, Wisconsin)

Research Scientist or Postdoctoral Researcher (Yokohama, Japan)

Faculty positions (Shanghai, P.R. China)

Director Department of Hematology (Stockholm, Sweden)

Multiple positions, in stem cell preclinical and clinical research (Santiago, Chile)

Members' Corner

ISEH applauds members' outstanding accomplishments

Congratulations to:

Sean J. Morrison for the publication in Cell Stem Cell of its manuscript entitled: "SLAM Family Markers Resolve Functionally Distinct Subpopulations of Hematopoietic Stem Cells and Multipotent Progenitors"(Cell Stem Cell,2013; 13(1):102-116).

Sonja Babovic, Philip A. Beer, David G. Kent, R. Keith Humphries and Connie J. Eaves for the publication in Nature Cell Biology of their manuscript entitled: "The Lin28b–let-7–Hmga2 axis determines the higher self-renewal potential of fetal haematopoietic stem cells"(Nature Cell Biology, 2013; 15, 916-925).