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Congratulations to ISEH Members

Posted By Connections Editor, Monday, December 21, 2015

Carl Walkley and colleges for the manuscript "RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself', Science; 2015;349:1115-20.

Shahin Rafii and colleges for the manuscript "Direct conversion of human amniotic cells into endothelial cells without transitioning through a pluripotent state", Nature Protocols,Published online 05 November 2015.

Emmanuelle Passegué and colleges for the manuscript"Replication stress caused by low MCM expression limits fetal erythropoiesis and hematopoietic stem cell functionality", Nat Commun., 2015; 6:8548.
Daniel T. Starczynowski and colleges for the paper "Loss of Tifab, a del(5q) MDS Gene, Alters Hematopoiesis through Derepression of Toll-Like Receptor-TRAF6 Signaling", JEM, 2015; 11: 1967-1985.

Ravindra Majeti and colleges for the paper "Leukemia-Associated Cohesin Mutants Dominantly Enforce Stem Cell Programs and Impair Human Hematopoietic Progenitor Differentiation", Cell Stem Cell, 2015; 6: 675–688,

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Congratulations ISEH Members

Posted By Connections Editor, Friday, November 6, 2015
Updated: Thursday, November 5, 2015

Junichiro Yuda, Ayano Yurino, Kohta Miyawaki and Koichi Akashi for their manuscript "A TIM-3/Gal-9 Autocrine Stimulatory Loop Drives Self-Renewal of Human Myeloid Leukemia Stem Cells and Leukemic Progression", published in Cell Stem Cell, 2015; 3, 341–352

Elaine Dzierzak for the paper "BMP Signalling Differentially Regulates Distinct Haematopoietic Stem Cell Types", published in Nature Communications , 2015 (epub ahead of print)

Dirk Loeffler, Hartmut Geiger, Michael D. Milsom, Timm Schroeder, Andreas Trumpp and Marieke Essers for the publication in Cell Stem Cell of the paper " Inflammation-Induced Emergency Megakaryopoiesis Driven by Hematopoietic Stem Cell-like Megakaryocyte Progenitors". Cell Stem Cell, 2015; 4, 422–434

Dirk Loeffler, Konstantinos D. Kokkaliaris, Max Endele and Timm Schroeder for the manuscript " Network plasticity of pluripotency transcription factors in embryonic stem cells", published in Nature Cell Biology, 2015; 17, 1235–1246

Min Ye, Scott A. Armstrong and Daniel G. Tenen for their manuscript ""Hematopoietic Differentiation Is Required for Initiation of Acute Myeloid Leukemia", published in Cell Stem Cell, 2015 (epub ahead of print)

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Congratulations to ISEH Members

Posted By Connections Editor, Monday, August 31, 2015
Updated: Tuesday, August 25, 2015

Catriona Jamieson, who will lead the University of California San Diego’s effort in the new GSK’s Discovery Partnerships with Academia bench-to-bedside project to treat leukemia and other diseases by eliminating cancer stem cells.

Reuben Kapur and Hal E. Broxmeyer for their manuscript " Enhancing Hematopoietic Stem Cell Transplantation Efficacy by Mitigating Oxygen Shock". Cell, 2015; 161, 1553–1565,

Georges Lacaud and Constanze Bonifer for the manuscript "Developmental-stage-dependent transcriptional response to leukaemic oncogene expression". Nat Commun., 2015;6:7203.

Iannis Aifantis and Sean Morrison for the paper "CXCL12-Producing Vascular Endothelial Niches Control Acute T Cell Leukemia Maintenance".Cancer Cell., 2015;27:755-68.

Kyle J. Hewitt and Emery H. Bresnick for the manuscript: " Hematopoietic Signaling Mechanism Revealed from a Stem/Progenitor Cell Cistrome". Mol Cell., 2015;59:62-74.

Berthold Göttgens and Emmanuelle Passegué for their manuscript: " Functionally Distinct Subsets of Lineage-Biased Multipotent Progenitors Control Blood Production in Normal and Regenerative Conditions". Cell Stem Cell.,2015;17:35-46

Eriko Nitta and Toshio Suda for the manuscript: " Aspp1 Preserves Hematopoietic Stem Cell Pool Integrity and Prevents Malignant Transformation". Cell Stem Cell., 2015;17:23-34.

Tatyana Grinenko, Konstantinos D. Kokkaliaris and Claudia Waskow for their manuscript: " CCND1-CDK4-mediated cell cycle progression provides a competitive advantage for human hematopoietic stem cells in vivo". J Exp Med., 2015 Jul 6 (Epub ahead of print)

Michael Cleary for the manuscript: " The H3K4-Methyl Epigenome Regulates Leukemia Stem Cell Oncogenic Potential". Cancer Cell, Epub ahead of print.

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Congratulations to ISEH Members

Posted By Connections Editor, Wednesday, July 1, 2015
Updated: Monday, June 29, 2015

Shahin Rafii, who is part of a consortium of scientists and transplant clinicians from the Ansary Stem Cell Institute at Weill Cornell Medical College and the Center for Cell Engineering at Memorial Sloan Kettering Cancer Center that has been awarded a $15.7 million, four-year research grant from the New York State Stem Cell Science Program to translate their innovative approach to expand and manipulate hematopoietic stem cells to cure acquired and inherited blood disorders.

Mickie Bhatia: Single Transcription Factor Conversion of Human Blood Fate to NPCs with CNS and PNS Developmental Capacity. Cell reports, Published Online: May 21, 2015.

Ihor R. Lemischka: Modeling Familial Cancer with Induced Pluripotent Stem Cells. Cell, 2015; 161, 240–254, and Tex10 Coordinates Epigenetic Control of Super-Enhancer Activity in Pluripotency and Reprogramming. Cell Stem Cell, 2015;16:1–16.

Iannis Aifantis: TET1 is a tumor suppressor of hematopoietic malignancy. Nat Immunol. 2015;16:653-662.

George Q. Daley and Leonard I. Zon: Adenosine signaling promotes hematopoietic stem and progenitor cell emergence. JEM, 2015; 212: 649.

Margaret A. Goodell: Long Non-Coding RNAs Control Hematopoietic Stem Cell Function. Cell Stem Cell. 2015;16:426-38.

Guy Sauvageau: Haploinsufficiency screen highlights two distinct groups of ribosomal protein genes essential for embryonic stem cell fate. Proc Natl Acad Sci U S A., 2015;112:2127-32.

David G. Kent, Anthony R. Green and Berthold Göttgens: Combined Single-Cell Functional and Gene Expression Analysis Resolves Heterogeneity within Stem Cell Populations. Cell Stem Cell, Available online 21 May 2015.


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Congratulations to the following ISEH members

Posted By Connections Editor, Friday, May 1, 2015
Updated: Tuesday, April 28, 2015

Congratulations to:
Irving Weissman, who was awarded a grant from the California Institute for Regenerative Medicine through the agency's "tools and technology" grant program to develop ways to generate better-tolerated, transplantable, blood-forming stem cells from induced pluripotent stem cells and to test new ways to prepare recipients for the transplantation of the cells.

Irving Weissman also won this year’s Charles Rodolphe Brupbacher Prize for Cancer Research for his work on healthy and sick stem cells.

Hanna Mikkola, who received the prestigious California Institute for Regenerative Medicine tools and technology award for her work creating a suite of engineered human pluripotent stem cell lines to facilitate the generation of patient specific hematopoietic stem cells.

Congratulations to the following members for the recent publication of their ground-breaking research:
Timm Schroeder, Hartmut Geiger, Michael A. Rieger, Marieke A. G. Essers, David A. Williams, Andreas Trumpp and Michael D. Milsom: Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells. Nature, 2015; Feb 18. [Epub ahead of print]

Shahin Rafii: Vascular niche promotes hematopoietic multipotent progenitor formation from pluripotent stem cells. J Clin Invest., 2015;125(3):1243–1254.

David G. Kent, Anna L. Godfrey and Anthony R. Green: Effect of Mutation Order on Myeloproliferative Neoplasms. N Engl J Med., 2015; 372:601-612.

John E. Dick: CDK6 Levels Regulate Quiescence Exit in Human Hematopoietic Stem Cells. Cell Stem Cell, 2015 Mar 5;16(3):302-13.

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Congratulations to the following ISEH members:

Posted By Connections Editor , Friday, February 27, 2015
Updated: Monday, February 23, 2015

George Daley for the publication of the paper " Deconstructing transcriptional heterogeneity in pluripotent stem cells", published in Nature. 2014 Dec 4;516(7529):56-61.

Benjamin Ebert for the publication in the N Engl J Med of the manuscript " Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes". N Engl J Med December 25, 2014; 371:2488-2498.

Michael Cleary for the paper " Human iPSC-derived motoneurons harbouring TARDBP or C9ORF72 ALS mutations are dysfunctional despite maintaining viability". Nat Commun. 2015 Jan 12;6:5999.

Stuart Orkin and Hanna Mikkola for their paper " Scl binds to primed enhancers in mesoderm to regulate hematopoietic and cardiac fate divergence", published online on January 5th in The EMBO Journal.

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Congratulations to the following members for the recent publication of their ground-breaking research

Posted By Connections Editor , Monday, January 5, 2015
Updated: Tuesday, December 30, 2014

Joydeep Ghosh, Kevin D. Bunting, Yan Liu, Rebecca J. Chan, Reuben Kapur: Regulation of Stat5 by FAK and PAK1 in Oncogenic FLT3- and KIT-Driven Leukemogenesis. Cell Reports, 2014 Nov 20;9(4):1333-48.


Denis-Claude Roy, Keith Humphries, Connie Eaves and Guy Sauvageau: Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal. Science. 2014 Sep 19;345(6203):1509-12.


Philip A. Beer, Gudmundur L. Norddahl , Ping Xiang, Tobias Berg, Connie J. Eaves and Keith Humphries: Modeling de novo leukemogenesis from human cord blood with MN1 and NUP98HOXD13. Blood. 2014 Oct 22. [Epub ahead of print]

Linheng Li: Megakaryocytes maintain homeostatic quiescence and promote post-injury regeneration of hematopoietic stem cells. Nat Med. 2014 Nov;20(11):1321-6.

Bruns Ingmar, Lucas Daniel, Ahmed Jalal, Kunisaki Yuya and Paul Frenette: Megakaryocytes regulate hematopoietic stem cell quiescence through CXCL4 secretion. Nat Med. 2014 Nov;20(11):1315-20.


David Traver: FGF signalling restricts haematopoietic stem cell specification via modulation of the BMP pathway. Nat Commun. 2014 Nov 27;5:5588.


Albert Kim, David Stachura, Clements Wilson K and David Traver: FGF signalling specifies haematopoietic stem cells through its regulation of somitic Notch signalling. Nat Commun. 2014 Nov 27;5:5583.

David Stachura, Albert Kim and David Traver: Proinflammatory signaling regulates hematopoietic stem cell emergence. Cell. 2014 Nov 20;159(5):1070-85.

Albert Kim, Wilson K.Clements, Daniel L Stachura and David Traver: Discrete Notch signaling requirements in the specification of hematopoietic stem cells. EMBO J. 2014 Oct 16;33(20):2363-73.

David Stachura and David Traver: Loss of IP3R-dependent Ca2+ signalling in thymocytes leads to aberrant development and acute lymphoblastic leukemia. Nat Commun. 2014 Sep 12;5:481.

Vincenzo Calvanese, Gay Crooks, Mattias Magnusson and Hanna Mikkola: GPI-80 Defines Self-Renewal Ability in Hematopoietic Stem Cells during Human Development. Cell Stem Cell, 2014 November 13, 2014, ahead of print


Ravi Bhatia: SIRT1 activation by a c-MYC oncogenic network promotes the maintenance and drug resistance of human FLT3-ITD acute Myeloid Leukemia stem cells. Cell Stem Cell. 2014 Oct 2;15(4):431-46.

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Congratulations to ISEH members' recent publications

Posted By Connections Editor, Tuesday, October 28, 2014
Congratulations to:
Simon Méndez-Ferrer for his manuscript "Neuropathy of haematopoietic stem cell niche is essential for myeloproliferative neoplasms", published in Nature,. 2014 Aug 7;512(7512):78-81.

Toshio Suda, Albert D Kim and David Traver for their paper "Jam1a-Jam2a interactions regulate haematopoietic stem cell fate through Notch signalling", published in Nature,. 2014 Aug 21;512(7514):319-23.


Grant Challen and Peggy Goodell for the publication of their paper "Dnmt3a and dnmt3b have overlapping and distinct functions in hematopoietic stem cells" in Cell Stem Cell. 2014 Sep 4;15(3):350-64.


Gordon Keller for his paper "Generation of the epicardial lineage from human pluripotent stem cells" published in Nat Biotechnol. 2014 Oct;32(10):1026-35.


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ISEH Applauds ISEH Members' Outstanding Accomplishments

Posted By Connections Editor, Friday, September 5, 2014
Updated: Wednesday, September 3, 2014


Congratulations to: 

ISEH 2014 New investigators awardees:


1st Place: Albert D. Kim, University of California, San Diego, USA
Notch3 is Required in the Somitic Mircoenvironment for the Specification of Hematopoietic Stem Cells

2nd Place: Jeffrey Bernitz, Ichan School of Medicine at Mount Sinai, USA
Label Retention Selects for Hematopoietic Stem Cells in Aged Bone Marrow and Distinguishes HSCs from Myeloid Restricted Progenitors

3rd place: Jalal Ahmed, Mount Sinai School of Medicine/ MSTP, USA
Dactus Venosus-associated Pericytes form a Niche Regulating Hematopoietic Stem Cell Proliferation in the Fetal Liver


1st place: Daniel D Lipka, German Cancer Research Center (DKFZ), Germany
Whole-genome Bisulfite Sequencing of HSCs and their Immediate Progeny Identifies Novel Regulatory Elements Involved in Self-renewal and Early Hematopoietic Commitment

2nd place: Magali Humbert, IRIC, Canada
LM01/2 Regulates DNA Replication in Hematopoietic Cells

3rd place: Yoshihiro Hayashi, Cincinnati Children's Hospital Medical Center, USA
Modeling and Targeting MLL-PTD/RUNX1 Related MDS/AML in Mouse

Edward Srour, Mervin Yoder, Reuben Kapur and Carlesso Nadia for the publication in Cell Stem Cell of their manuscript " Notch-dependent repression of miR-155 in the bone marrow niche regulates hematopoiesis in an NF-κB-dependent manner." 2014 Jul 3;15(1).

Again to Nadia Carlesso for her paper "Inhibition of Notch signaling promotes browning of white adipose tissue and ameliorates obesity." published in Nat Med. 2014 Aug;20(8).

Yuya Kunisaki, Scott Armstrong and Paul Frenette for the publication in Cell Stem Cell of their paper "Acute Myelogenous Leukemia-Induced Sympathetic Neuropathy Promotes Malignancy in an Altered Hematopoietic Stem Cell Niche." 2014 Jul 9. [Epub ahead of print].

Kelli Carroll, Virginei Esain, Mauricio Cortes, Wanda Kwan and Trista North for their paper "Estrogen defines the dorsal-ventral limit of VEGF regulation to specify the location of the hemogenic endothelial niche." published in Dev Cell. 2014 May 27;29(4).


See photos of the award winners at the Annual Meeting below - click here to learn more about the awards










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ISEH Applauds Members' Outstanding Accomplishments

Posted By Connections Editor, Monday, June 30, 2014
Updated: Wednesday, June 25, 2014

Congratulations to:

Paul Frenette for the publication of the manuscript entitled "Osterix Marks Distinct Waves of Primitive and Definitive Stromal Progenitors during Bone Marrow Development" published in  Dev Cell in May 12 2014.

Katherine King and Margaret (Peggy) Goodell for the publication in Nature May 25 2014 of their paper entitled "mTORC1 controls the adaptive transition of quiescent stem cells from G0 to G.Alert.

 Bertie Göttgens  and Margaret (Peggy) Goodell for the publication in Cell Stem Cell in May 1 2014 of the paper "Epigenomic Profiling of Young and Aged HSCs Reveals Concerted Changes during Aging that Reinforce Self-Renewal".

Hind Medyouf,  Amelie Lie and Andreas Trumpp for their manuscript "Myelodysplastic Cells in Patients Reprogram Mesenchymal Stromal Cells to Establish a Transplantable Stem Cell Niche Disease Unit",  published in Cell Stem Cell in Apr 3 2014.

 Christine Miller and Amy Wagers for the publication in Science, May 9 2014, of their papers: "Vascular and neurogenic rejuvenation of the aging mouse brain by young systemic factors" and

"Restoring systemic GDF11 levels reverses age-related dysfunction in mouse skeletal muscle" .

Peter van Galen, David Kent,  Kolja Eppert,  Anthony  Green and John  Dick for their manuscript "The unfolded protein response governs integrity of the haematopoietic stem-cell pool during stress", published in Nature in April 28 2014.

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8/23/2018 » 8/26/2018
ISEH 47th Annual Meeting - Los Angeles, CA

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