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Posted By Connections Editor,
Friday, April 13, 2018
Updated: Wednesday, April 11, 2018
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Radek Skoda for the paper, “A Gain-of-Function Mutation in EPO in Familial Erythrocytosis.” N Engl J Med. 2018 Mar 8;378(10):924-930. doi: 10.1056/NEJMoa1709064.
Stuart Orkin and Jian Xufor the paper, “Direct Promoter Repression by BCL11A Controls the Fetal to Adult Hemoglobin Switch.” Cell. 2018 Apr 5;173(2):430-442.e17. doi: 10.1016/j.cell.2018.03.016.
Hal Broxmeyer for the paper, “Antagonism of PPAR-γ signaling expands human hematopoietic stem and progenitor cells by enhancing glycolysis." Nat Med. 2018 Mar;24(3):360-367. doi: 10.1038/nm.4477.
Lei Ding for the paper, “Hepatic thrombopoietin is required for bone marrow hematopoietic stem cell maintenance.” Science. 2018 Apr 6;360(6384):106-110. doi: 10.1126/science.aap8861.
Paul Frenette for the paper, “Lineage-Biased Hematopoietic Stem Cells Are Regulated by Distinct Niches.” Dev Cell. 2018 Mar 12;44(5):634-641.e4. doi: 10.1016/j.devcel.2018.01.016.
Christophe Lancrin for the paper, “Single-cell transcriptomics reveals a new dynamical function of transcription factors during embryonic hematopoiesis.” Elife. 2018 Mar 20;7. pii: e29312. doi: 10.7554/eLife.29312.
Margaret Goodell and Grant Challen for the paper, “Loss of Dnmt3a Immortalizes Hematopoietic Stem Cells In Vivo.” Cell Reports, April 3; 23 (1) 1-10. doi: 10.1016/j.celrep.2018.03.025.
Tomohiko Tamura for the paper, “Transcription Factor IRF8 Governs Enhancer Landscape Dynamics in Mononuclear Phagocyte Progenitors.” Cell Rep. 2018 Mar 6;22(10):2628-2641. doi: 10.1016/j.celrep.2018.02.048.
George Lacaud and Christophe Lancrin for the paper, “Regulation of RUNX1 dosage is crucial for efficient blood formation from hemogenic endothelium.” Development. 2018 Mar 12;145(5). pii: dev149419. doi: 10.1242/dev.149419.
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Posted By Connections Editor,
Friday, March 16, 2018
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Congrats to:
Emery Bresnick, Robert Paulson and colleagues for the paper “Mechanisms of erythrocyte development and regeneration: implications for regenerative medicine and beyond”
Development 145(1). pii: dev151423. doi: 10.1242/dev.151423
Huang Xu, Hal Broxmeyer Antagonism and colleagues for the paper “PPAR-γ signaling expands human hematopoietic stem and progenitor cells by enhancing glycolysis”
Nat Med doi: 10.1038/nm.4477
Grant Challen and colleagues for the paper “The GNASR201C mutation associated with clonal hematopoiesis supports transplantable hematopoietic stem cell activity”
Exp Hematol 57:14-20. doi: 10.1016/j.exphem.2017.09.004
Elaine Dzierzak and colleagues for the paper ”In vivo single cell analysis reveals Gata2 dynamics in cells transitioning to hematopoietic fate”
J Exp Med 215(1):233-248. doi:10.1084/jem.20170807
Chiara Pirillo, Louise Purton, Cristina Lo Celso and colleagues for the paper “Inhibition of Endosteal Vascular Niche Remodeling Rescues Hematopoietic Stem Cell Loss in AML”
Cell Stem Cell 22(1):64-77.e6. doi: 10.1016/j.stem.2017.11.006
Claus Nerlov and colleagues for the paper “Hierarchically related lineage-restricted fates of multipotent haematopoietic stem cells”
Nature 554(7690):106-111 doi: 10.1038/nature25455.
Xuan Pan and colleagues for the paper “Polycomb Group Protein YY1 Is an Essential Regulator of Hematopoietic Stem Cell Quiescence”
Cell Rep 22(6):1545-1559 doi:10.1016/j.celrep.2018.01.026.
David Scadden and colleagues for the paper “Bone marrow drives central nervous system regeneration after radiation injury”
J Clin Invest 128(1):281-293. doi: 10.1172/JCI90647
Nancy Speck and colleagues for the paper “Runx1 is sufficient for blood cell formation from non-hemogenic endothelial cells in vivo only during early embryogenesis” Development 145(2). pii: dev158162. doi: 10.1242/dev.158162.
Daniel Starczynowski and colleagues for the paper “TRAF6 Mediates Basal Activation of NF-κB Necessary for Hematopoietic Stem Cell Homeostasis”
Cell Rep 22(5):1250-1262. doi: 10.1016/j.celrep.2018.01.013.
Claudia Waskow and colleagues for the paper “SETD1A protects HSCs from activation-induced functional decline in vivo”
Blood pii: blood-2017-09-806844. doi: 10.1182/blood-2017-09-806844
Grover Bagby for the review “Recent advances in understanding hematopoiesis in Fanconi Anemia”
F1000Res 7:105. doi: 10.12688/f1000research.13213.1.
Bruce Blazar and colleague for the review “Pathophysiology of Chronic Graft-versus-Host Disease and Therapeutic Targets”
N Engl J Med 377(26):2565-2579. doi: 10.1056/NEJMra1703472.
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Posted By Connections Editor,
Monday, August 28, 2017
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Congrats to:
Feng Liu, Lu Wang, Dongyuan Ma and colleagues for The Vascular Niche Regulates Hematopoietic Stem and Progenitor Cell Lodgment and Expansion via klf6a-ccl25b
Cell Developmental Cell 42:4, 349-362 doi:10.1016/j.devcel.2017.07.012
Sean J. Morrison and colleagues for Bone marrow adipocytes promote the regeneration of stem cells and haematopoiesis by secreting SCF
Nature Cell Biology 19, 891–903 (2017) doi:10.1038/ncb3570
Isabel Beerman, Francois E. Mercier, David T. Scadden, and colleagues for ZFP521 regulates murine hematopoietic stem cell function and facilitates MLL-AF9 leukemogenesis in mouse and human cells
Blood 2017 130:619-624; doi: 10.1182/blood-2016-09-738591
Benjamin L. Ebert and colleague for Prevalent premalignancy
Blood 2017 130:695-696; doi: 10.1182/blood-2017-05-786210
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Posted By Administration,
Tuesday, June 20, 2017
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Congrats to these ISEH Members:
Thalia Papayanoulou and colleagues for the paper "A self-sustained loop of inflammation-driven inhibition of beige adipogenesis in obesity" Nature Immunology 18, 654–664 (2017) doi:10.1038/ni.3728
David Scadden and colleagues for the paper "Hematopoiesis: Reconciling Historic Controversies about the Niche" Cell Stem Cell Vol. 20-5 (2017) doi:10.1016/j.stem.2017.03.025
Wilson Clements and Erich Damm for "Pdgf signalling guides neural crest contribution to the haematopoietic stem cell specification niche" Nature Cell Biology 19, 457–467 (2017) doi:10.1038/ncb3508
Isabel Beerman, Tiago Lius, Sofie Singbrant, Cristina Lo Celso, and Simon Méndez-Ferrer for the review "The evolving view of the hematopoietic stem cell niche" Experimental Hematology 50, 22-26 (2017) doi:10.1016/j.exphem.2017.01.008
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Posted By Connections Editor,
Friday, April 28, 2017
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Congrats to these ISEH members:
Fiona Hamey and Bertie Göttgens for Demystifying blood stem cell fates
Nature Cell Biology 19, 261–263 (2017) doi:10.1038/ncb3494
Catherine Porcher and colleagues for SCL/TAL1: a multifaceted regulator from blood development to disease
Blood 2017 129:2051-2060; doi:10.1182/blood-2016-12-754051
Marella de Bruijn and Elaine Dzierzak for Runx transcription factors in the development and function of the definitive hematopoietic system
Blood 2017 129:2061-2069; doi:10.1182/blood-2016-12-689109
Bartosch Wojcik, J.H. Frederik Falkenburg, Timm Schroeder, Michael Rieger and colleagues for Plastic CD34 and CD38 expression in adult B–cell precursor acute lymphoblastic leukemia explains ambiguity of leukemia-initiating stem cell populations
Leukemia (2017) 31, 731–734; doi:10.1038/leu.2016.315
Emery Bresnick and colleague for The GATA factor revolution in hematology
Blood 2017 129:2092-2102; doi:10.1182/blood-2016-09-687871
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Posted By Connections Editor,
Friday, February 24, 2017
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Congrats to:
David Traver, Len Zon and colleagues for Corrigendum: Clonal fate mapping quantifies the number of haematopoietic stem cells that arise during development
Nature Cell Biology 19, 142 (2017) doi:10.1038/ncb3462
Peter van Galen and colleagues for Adaptive Chromatin Remodeling Drives Glioblastoma Stem Cell Plasticity and Drug Tolerance
Cell Stem Cell 20.2 dx.doi.org/10.1016/j.stem.2016.11.003
Eirini Trompouki, Eugenia Flores-Figueroa, Daniel Lucas, and Teresa V. Bowman for From the bedside to the bench: new discoveries on blood cell fate and function
Experimental Hematology Vol. 47 dx.doi.org/10.1016/j.exphem.2016.11.007
Grant Challan for Dominating the Negative: How DNMT3A Mutations Contribute to AML Pathogenesis
Cell Stem Cell 20.1 dx.doi.org/10.1016/j.stem.2016.12.008
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Posted By Connections Editor,
Wednesday, December 14, 2016
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Congrats to:
E. Camilla Forsberg and colleagues for A Transient Developmental Hematopoietic Stem Cell Gives Rise to Innate-like B and T Cells
Cell Stem Cell 1 Dec 2016 http://www.cell.com/cell-stem-cell/fulltext/S1934-5909(16)30260-0
Kateri Moore, Jeffrey Bernitz and colleagues for Hematopoietic Stem Cells Count and Remember Self-Renewal Divisions
Cell 17 Nov 2016 http://dx.doi.org/10.1016/j.cell.2016.10.022
Xiang Li and colleagues for Quantitative proteomic analysis and comparison of two bone marrow stromal cell lines using the SILAC method
Experimental Hematology vol. 44-11 http://dx.doi.org/10.1016/j.exphem.2016.08.002
Simon Mendez-Ferrer and colleague for Under Pressure: When a Transformed Environment Pushes Cells to Malignancy
Cell Stem Cell 3 Nov 2016 http://dx.doi.org/10.1016/j.stem.2016.10.012
Tao Cheng and colleagues for Cytogenetics and molecular genetics
Loss of Dnmt3b accelerates MLL-AF9 leukemia progression
Leukemia (2016) 30, 2373–2384 http://www.nature.com/leu/journal/v30/n12/full/leu2016112a.html
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Posted By Connections Editor,
Monday, October 17, 2016
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Congratulations to:
David Kent, Bertie Göttgens, Elaine Dzierzak, Leonard I. Zon, John E. Pimanda and colleagues for "Identification of novel regulators of developmental hematopoiesis using Endoglin regulatory elements as molecular probes"
Blood 2016 128:1928-1939
Markus G. Manz and colleagues for "Peripheral blood CD34+ cells efficiently engraft human cytokine knock-in mice"
Blood 2016 128:1829-1833
David T. Scadden, Cristina Lo Celso and colleagues "Proximity-Based Differential Single-Cell Analysis of the Niche to Identify Stem/Progenitor Cell Regulators"
Cell Stem Cell Volume 19, Issue 4 p530–543, 6 October 2016
Tiago C. Luis, Cedric S. Tremblay, Markus G. Manz, Trista E. North, Katherine Y. King, and Grant A. Challen for "Inflammatory signals in HSPC development and homeostasis: Too much of a good thing?"
Experimental Hematology Volume 44, Issue 10, Pages 908–912
Paul Frenette and colleagues for "Targeting Mac-1-mediated leukocyte–RBC interactions uncouples the benefits for acute vaso-occlusion and chronic organ damage"
Experimental Hematology Volume 44, Issue 10, Pages 940–946
Hartmut Geiger and colleague for "Aging of hematopoietic stem cells: DNA damage and mutations?"
Experimental Hematology Volume 44, Issue 10, Pages 895–901
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Posted By Connections Editor,
Friday, August 19, 2016
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Congratulations to:
Koichi Akashi and colleagues for "Calreticulin mutation does not contribute to disease progression in essential thrombocythemia by inhibiting phagocytosis" [ExpHem]
Experimental Hematology Volume 44, Issue 9.
Teresa V. Bowman and colleagues for "Spliceosomal component Sf3b1 is essential for hematopoietic differentiation in zebrafish" [ExpHem]
Experimental Hematology Volume 44, Issue 9.
Margaret A. Goodell and colleagues for "Mixed-phenotype acute leukemia (MPAL) exhibits frequent mutations in DNMT3A and activated signaling genes"
Experimental Hematology Volume 44, Issue 8.
E. Camilla Forsberg and colleagues for "Hematopoietic stem cell-specific GFP-expressing transgenic mice generated by genetic excision of a pan-hematopoietic reporter gene"
Experimental Hematology Volume 44, Issue 8.
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Posted By Connections Editor,
Thursday, June 9, 2016
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Congratulations to:
R. Grant Rowe, Leonard I. Zon, George Q. Daley and colleagues for "Engineering Hematopoietic Stem Cells: Lessons from Development"
Cell Stem Cell Volume 18, Issue 6.
Elaine Dzierzak and colleagues for "Subregional localization and characterization of Ly6aGFP-expressing hematopoietic cells in the mouse embryonic head"
Developmental Biology 25 May 2016
Sean J. Morrison and colleagues for "Leptin Receptor Promotes Adipogenesis and Reduces Osteogenesis by Regulating Mesenchymal Stromal Cells in Adult Bone Marrow
Cell Stem Cell Volume 18, Issue 6.
Konstantinos D. Kokkaliaris, Daniel Lucas, Isabel Beerman, David G. Kent, and Leïla Perié for Understanding hematopoiesis from a single-cell standpoint"
Experimental Hematology Volume 44, Issue 6.
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