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Inside this issue: Jan/Feb

Posted By Connections Editor, Tuesday, February 28, 2017



Using zebrafish models of leukemia to streamline drug screening and discovery
Adam P. Deveau, Victoria L. Bentley, Jason N. Berman

Novel strategies of adoptive immunotherapy: How natural killer cells may change the treatment of elderly patients with acute myeloblastic leukemia
Roberto M. Lemoli, Sarah Parisi, Antonio Curti

Tumor necrosis factor α in the onset and progression of leukemia
Xiaoxi Zhou, Zhuoya Li, Jianfeng Zhou

Clinical-grade regulatory T cells: Comparative analysis of large-scale expansion conditions

Sarvari Velaga, Christina Alter, Ulrike Dringenberg, Christina T. Thiesler, Sandra Kuhs, Sven Olek, Sya N. Ukena, Anke Franzke

AC220 and AraC cause differential inhibitory dynamics in patient-derived M5-AML with FLT3-ITD and, thus, ultimately distinct therapeutic outcomes
Xiaoyu An, Jinping Liu, Na Wang, Di Wang, Liang Huang, Likun Zhang, Jie Cai, Jean-Pierre Wery, Demin Zhou, Jianfeng Zhou, Qi-Xiang Li

Constitutive Kit activity triggers B-cell acute lymphoblastic leukemia-like disease in mice
Robin R. Weidemann, Rayk Behrendt, Kristina B. Schoedel, Werner Müller, Axel Roers, Alexander Gerbaulet

Alterations in the bone marrow microenvironment may elicit defective hematopoiesis: a comparison of aplastic anemia, chronic myeloid leukemia, and normal bone marrow
Meerim Park, Chan-Jeoung Park, Young Wook Cho, Seongsoo Jang, Jung-Hee Lee, Je-Hwan Lee, Kyoo-Hyung Lee, Young Ho Lee

The AMP-activated protein kinase beta 1 subunit modulates erythrocyte integrity
Emma L. Cambridge, Zoe McIntyre, Simon Clare, Mark J. Arends, David Goulding, Christopher Isherwood, Susana S. Caetano, Carmen Ballesteros Reviriego, Agnieszka Swiatkowska, Leanne Kane, Katherine Harcourt, The Sanger Mouse Genetics Project, David J. Adams, Jacqueline K. White, Anneliese O. Speak

Sustained enhancement of OCTN1 transporter expression in association with hydroxyurea induced γ-globin expression in erythroid progenitors
Aisha L. Walker, Solomon F. Ofori-Acquah

Pharmacological inhibition of AKT activity in human CD34+ cells enhances their ability to engraft immunodeficient mice
Sisi Chen, Rui Gao, Michihiro Kobayashi, Hao Yu, Chonghua Yao, Reuben Kapur, Mervin C. Yoder, Yan Liu

Proinflammatory signals are insufficient to drive definitive hematopoietic specification of human HSCs in vitro

Alessandra Giorgetti, Julio Castaño, Clara Bueno, Rafael Díaz de la Guardia, Mario Delgado, Anna Bigas, Lluis Espinosa, Pablo Menendez



Ikaros: Exploiting and targeting the hematopoietic stem cell niche in B-progenitor acute lymphoblastic leukemia
Michelle L. Churchman, Charles G. Mullighan

Granulocyte colony-stimulating factor receptor signaling in severe congenital neutropenia, chronic neutrophilic leukemia, and related malignancies
Pankaj Dwivedi, Kenneth D. Greis

Transcriptional activation by MLL fusion proteins in leukemogenesis
Akihiko Yokoyama

Dynamic variation of CD5 surface expression levels within individual chronic lymphocytic leukemia clones
Rachael J.M. Bashford-Rogers, Anne L. Palser, Clare Hodkinson, Joanna Baxter, George A. Follows, George S. Vassiliou, Paul Kellam

Genetically re-engineered K562 cells significantly expand and functionally activate cord blood natural killer cells: Potential for adoptive cellular immunotherapy

Janet Ayello, Jessica Hochberg, Allyson Flower, Yaya Chu, Laxmi V. Baxi, William Quish, Carmella van de Ven, Mitchell S. Cairo

Lenalidomide enhances the function of dendritic cells generated from patients with multiple myeloma
Manh-Cuong Vo, Truc Anh-NguyenThi, Hyun-Ju Lee, Thanh-Nhan Nguyen-Pham, Thangaraj Jaya Lakshmi, Sung-Hoon Jung, Hyeoung-Joon Kim, Je-Jung Lee

MiR-17-92 represses PTPROt and PP2A phosphatases and amplifies tonic BCR signaling in DLBCL cells
Ewa Jablonska, Patryk Gorniak, Maciej Szydlowski, Tomasz Sewastianik, Emilia Bialopiotrowicz, Anna Polak, Krzysztof Warzocha, Przemyslaw Juszczynski

AML1–ETO promotes SIRT1 expression to enhance leukemogenesis of t(8;21) acute myeloid leukemia
Lei Zhou, Qian Wang, Xiaosu Chen, Lin Fu, Xiaodong Zhang, Lijun Wang, Ailing Deng, Dandan Li, Jing Liu, Na Lv, Lili Wang, Yonghui Li, Daihong Liu, Li Yu, Liping Dou

Csk-binding protein controls red blood cell development via regulation of Lyn tyrosine kinase activity
Janice H.C. Plani-Lam, Neli S. Slavova-Azmanova, Nicole Kucera, Alison Louw, Jiulia Satiaputra, Peter Singer, Kong-Peng Lam, Margaret L. Hibbs, Evan Ingley

HIF1α-induced PDGFRβ signaling promotes developmental HSC production via IL-6 activation
Sung-Eun Lim, Virginie Esain, Wanda Kwan, Lindsay N. Theodore, Mauricio Cortes, Isaura M. Frost, Sarah Y. Liu, Trista E. North

Erratum to “Effect of roflumilast, novel phosphodiesterase-4 inhibitor, on lung chronic graft-versus-host disease in mice”
Sei Won Kim, Ji Young Lim, Chin Kook Rhee, Ji Hye Kim, Chan Kwon Park, Tae Jung Kim, Chul Soo Cho, Chang Ki Min, Hyoung Kyu Yoon

Erratum to “Autophagy regulates the cell cycle of mouse HSPCs in a nutrient-dependent manner”
Yan Cao, Aihong Zhang, Jinyang Cai, Na Yuan, Weiwei Lin, Shengbing Liu, Fei Xu, Lin Song, Xin Li, Yixuan Fang, Zhen Wang, Zhijian Wang, Jian Wang, Han Zhang, Wenli Zhao, Shaoyan Hu, Suping Zhang, Jianrong Wang


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