Clonal Evolution of Pre-Leukemic HSCs in AML
Wednesday, 3 June 2015, 2:30 - 4:00 pm EST
The identity of the cell of origin for hematologic malignancy as well as the mechanism via which cellular transformation is achieved, have both been topics of much debate within the hematology community for many years. The advent of next generation sequencing technologies has provided a route through which increased resolution of this process can be attained. Using this technology, a number of recent high profile publications have characterized an age-associated increase in the genomic mutation frequency within the hematopoietic stem cell compartment associated with non-malignant expansion of individual stem cell clones. Frequently, these mutations occur in epigenetic modifiers such as DNMT3a, IDH1/2 and TET2, which are also often found in leukemia. This suggests that epigentic instability may be a major driving force in this clonal evolution and that this process may be an age-related step towards transformation.
In the next ISEH webinar, two leaders in this field, Drs. Ross Levine and Ravi Majeti, will discuss the recent advances in this research topic and will discuss the insights that their work brings to our understanding of HSC clonal evolution during aging and its relationship to leukemogenesis. Dr. Ross Levine is a physician scientist at Memorial Sloan Kettering Cancer Center, New York, who leads a research group that has a major focus on understanding the genetic basis of myeloid malignancies. Dr. Ravi Majeti is also a clinician scientist who leads a research group based at Stanford School of Medicine with research interests centred on the characterization and targeting of leukemia stem cells.
The webinar will take place on Wednesday, 3 June 2015 at 2:30 to 4:00 pm EST and will be moderated by Dr. Ann Mullally, Assistant Professor of Medicine at Harvard Medical School and Brigham and Women’s Hospital, Boston. Be sure to register to see what promises to be a great webinar on one of the current hot topics in hematology led by world-renowned experts in the field. This will be followed by an interactive discussion where you can submit questions to any of the webinar participants.