Contributed by Eugenia Figueroa-Flores, ISEH New Investigator Committee
is changing the way we do and share science. As an international society,
webinars are a useful tool to keep our members informed and connected
throughout the year.
23rd, the New Investigator Committee hosted the second ISEH webinar, featuring a
discussion between two of our prominent members and leaders in the field of the
hematopoietic stem cell niche. David Scadden and Paul Frenette gave an overview
of the field and shared their latest results. With Andreas Trumpp as the
moderator, the webinar/debate flowed smoothly and was interesting from
beginning to end.
speakers demonstrated how improved technologies have reshaped our view of the
stem cell niche and given us a clearer picture of the murine bone marrow
architecture and the location of hematopoietic stem cells.
stromal cells were the big winners from our event, as both speakers agreed on
their relevance as key regulators of the stem cell niche. The hematopoietic stem cell niche field is under
constant refinement. Whether the endosteal or vascular niche is the main
site for hematopoiesis remains unanswered. Paul Frenette showed detailed analysis
of sinusoid distribution on the bone marrow that supports a perivascular
location for hematopoietic stem cells, although David Scadden pointed out that
under conditions unfavorable for the vasculature, osteoblasts could take on the
supportive role. As with most biology, context is key.
If you missed the
live broadcast or want to view it again, we invite you to check our webpage and
follow our social media, as the webinar recording will be available soon. We
were inspired by our speakers and from the 100% satisfaction of our
participants, so were you! We invite you to stay tuned for the next webinar
from ISEH and from the New Investigator Committee coming soon.