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Stem cell niche webinar recap

Posted By Connections Editor, Friday, November 01, 2013
Updated: Monday, October 28, 2013

Contributed by Eugenia Figueroa-Flores, ISEH New Investigator Committee

Technology is changing the way we do and share science. As an international society, webinars are a useful tool to keep our members informed and connected throughout the year.

On September 23rd, the New Investigator Committee hosted the second ISEH webinar, featuring a discussion between two of our prominent members and leaders in the field of the hematopoietic stem cell niche. David Scadden and Paul Frenette gave an overview of the field and shared their latest results. With Andreas Trumpp as the moderator, the webinar/debate flowed smoothly and was interesting from beginning to end.

The speakers demonstrated how improved technologies have reshaped our view of the stem cell niche and given us a clearer picture of the murine bone marrow architecture and the location of hematopoietic stem cells.

Mesenchymal stromal cells were the big winners from our event, as both speakers agreed on their relevance as key regulators of the stem cell niche. The hematopoietic stem cell niche field is under constant refinement. Whether the endosteal or vascular niche is the main site for hematopoiesis remains unanswered. Paul Frenette showed detailed analysis of sinusoid distribution on the bone marrow that supports a perivascular location for hematopoietic stem cells, although David Scadden pointed out that under conditions unfavorable for the vasculature, osteoblasts could take on the supportive role. As with most biology, context is key.


If you missed the live broadcast or want to view it again, we invite you to check our webpage and follow our social media, as the webinar recording will be available soon. We were inspired by our speakers and from the 100% satisfaction of our participants, so were you! We invite you to stay tuned for the next webinar from ISEH and from the New Investigator Committee coming soon.

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