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Inaugural Webinar Recap

Posted By Connections Editor, Sunday, June 30, 2013
Updated: Friday, June 28, 2013

June 4th 2013-"Combinatorial Transcriptional Control of Blood Stem and Progenitor Cells"

Dr. Bertie
Göttgens from the Cambridge Institute for Medical Research presented his group's research efforts into constructing hematopoietic transcriptional networks from single cell data. The webinar highlighted the application of the Fluidigm BioMark platform, a basically a high throughput qPCR system that allows the assay of multiple genes in multiple cells in parallel, and principal component analysis (PAC), to study such networks. Dr. Göttgens exemplified how this approach combined with ChIP-Seq, transgenic mice and repressor assays, demonstrated a negative correlation between Gata2 and Gfi1 which was present only in stem cells. The last part of the webinar was dedicated to a live demonstration of the use of gene set control analysis for the identification of transcription networks using the HAEMCODE, a comprehensive collection of ChIP-Sep experiments on the hematopoietic development.

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