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Current Career & Fellowship Opportunities

Postings are up for 60 days

 

 

POSTDOC POSITION AVAILABLE

Cedars-Sinai Medical Center
Los Angeles, USA

 

Mechanisms of Myeloid Cell Differentiation and Functional Programming Cedars-Sinai Medical Center, Los Angeles Helen Goodridge PhD is looking for a postdoctoral scientist to join her team at Cedars-Sinai Medical Center, Los Angeles to study mechanisms underlying the differentiation and functional programming of monocytes and neutrophils, building on the lab’s previous studies of myelopoiesis (including Blood, 2015 and Immunity, in press). Candidates should have an interest and prior expertise in immunology and/or hematology, with strong experience of flow cytometry, tissue culture, molecular biology (e.g. RNA-seq, ChIP, DNA barcoding) and rodent studies (e.g. adoptive transfer, bone marrow transplantation). Bioinformatics/computational experience would be an advantage.

 

The Goodridge lab, which is located in the Cedars-Sinai Regenerative Medicine Institute and affiliated with the Cedars-Sinai Research Division of Immunology, studies the production and functional programming of myeloid cells (neutrophils, monocytes, macrophages and DCs), and their roles in infectious and inflammatory diseases, aging and tissue regeneration. Contact helen.goodridge@csmc.edu to apply or for more information.

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Postdoctoral Position in Cellular Reprogramming and Hematopoiesis

Lund University

Lund, Sweden


The Reprogramming and Hematopoiesis lab is currently seeking a highly motivated postdoctoral fellow!

Reprogramming and Hematopoiesis lab
Cellular reprogramming can be achieved experimentally in different ways, including nuclear transfer, cell fusion or expression of transcription factors. We aim to uncover how hematopoietic stem cell and effector cell identity is established employing cellular reprogramming logic. Ultimately our work may allow the generation of patient-specific hematopoietic cells for regenerative medicine and immunotherapy. To explore these aims, we use a variety of approaches, including cellular reprogramming through gene transduction (Pereira et al, Cell Stem Cell, 2013) and single cell gene expression profiling during embryonic development (Pereira et al, Developmental Cell, 2016). Hematopoiesis is a core area of research at the Medical Faculty at Lund University. Within this broader research area the Division of Molecular Medicine and Gene therapy harbors an ensemble of international research groups with a focus on understanding both normal and malignant hematopoiesis and to develop new strategies for therapeutic intervention. Our lab is generously funded by the Wallenberg Centre for Molecular Medicine and the Knut and Alice Wallenberg Foundation.

Candidate Profile
The candidate should be an enthusiastic and motivated scientist willing to join a young international research group in a highly dynamic and multidisciplinary environment (with English as main language). Candidates with a passion for cell identity and epigenetics as well as immunology and/or hematopoiesis who recently completed their PhD thesis or currently finishing up are encouraged to apply. The successful candidate will join a research program at the interface between the fields of cellular reprogramming and stem cells, hematopoiesis and oncoimmunology. Excellent verbal and written communication skills in English are required.


Research at Lund University
Lund University is Scandinavia’s largest institution for education and research and consistently ranks among the world’s top 100 universities. The Lund Stem Cell Center hosts 15 research groups in experimental hematology and is one of Europe’s most prominent in the field of hematopoietic research. This environment has all facilities and equipment essential for the project including an outstanding animal facility, technical platforms for flow cytometry and cell sorting, a human ES/iPS core facility, viral vector technology and single cell genomics facility. This creates a very interactive environment with weekly seminars and annual retreats for students, postdocs and PIs.

Experimental Approaches
Key approaches will include flow cytometry, high-content automated image acquisition and analysis, single cell gene expression and chromatin profiling, cellular transplantation, Crispr/Cas9 and small molecule screening and the generation and characterization of new mouse models.

How to apply
Please send a letter of motivation, your curriculum vitae, and the contacts for three references to:
Assistant Professor Carlos-Filipe Pereira
Contact: filipe.pereira@med.lu.se

References
Pereira, C.F.**; Chang, B.; Gomes, A.; Bernitz, B.; Papatsenko, D.; Niu, X.; Swiers, G.; Azzoni, E.; Brujin M.F.T.R.; Schaniel, C.; Lemischka, I.R.; Moore, K.A. Hematopoietic Reprogramming In Vitro Informs In Vivo Identification of Hemogenic Precursors to Definitive Hematopoietic Stem Cells. Developmental Cell 2016, 36 (5), 525-39. **corresponding author.

Pereira, C. F. **; Chang, B.; Qiu, J.; Niu, X.; Papatsenko, D.; Hendry, C. E.; Clark, N. R.; Nomura-Kitabayashi, A.; Kovacic, J. C.; Ma'ayan, A.; Schaniel, C.; Lemischka, I. R.; Moore, K., Induction of a hemogenic program in mouse fibroblasts. Cell Stem Cell 2013, 13 (2), 205-18. **corresponding author.

 

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Postdoctoral Positions Available - Department of Hematology

St. Jude Children's Research Hospital
Memphis, TN, USA

Positions are available in the Department of Hematology at St. Jude Children’s Research Hospital (Memphis, Tennessee, USA) to study hematopoietic stem cell biology and development. Our laboratory has two major areas of focus: characterizing novel molecular regulators of hematopoietic stem cell transplantation and discovering novel mechanisms that regulate the emergence of the blood system during mammalian embryogenesis. We employ mouse genetics, ex vivo cell culture, flow cytometry, and molecular biology to study HSC biology. This position is ideal for someone with a Ph.D and/or M.D. seeking to develop expertise in stem cell biology in an intimate and vibrant laboratory setting.

St. Jude Children’s Research Hospital, located in Memphis, Tennessee, USA, is a premier center for research and treatment of potentially fatal childhood diseases, including cancer and certain blood, genetic, and immunodeficiency disorders. The hospital’s mission is to advance cures, and means of prevention, for pediatric catastrophic diseases through research and treatment. St. Jude is dedicated to providing unsurpassed patient care and to advancing the health of children through biomedical research.

If interested, please contact Shannon McKinney-Freeman at Shannon.mckinney-freeman@stjude.org

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POSTDOCTORAL SCIENTIST – STEM CELL BIOLOGY - investigating the development of the haematopoietic system

Cancer Research UK , University of Manchester

  • Salary in the range of £30,000 - £39,800 (dependent upon qualifications and experience)
  • Job Ref: MI/17/56
  • Commencement of post: January 2018
  • Duration of post: 3 years (in first instance)

We are looking for a highly motivated Postdoctoral Scientist to join the laboratory of Professor Georges Lacaud to investigate the development of the haematopoietic system. Understanding how blood cells are generated is important from a biological perspective but has also tremendous potential implications for the treatment of blood diseases. The successful candidate will perform single cell expression and epigenetic analyses, in collaboration with our Bioinformatician, to reveal new hierarchical relationships, infer pathways of differentiation and uncover new regulatory interactions sustaining blood development. The hypotheses generated in silico will be evaluated using state-of-the-art mouse models, CRISPR genome editing and ES cell cultures.

The applicant should have a PhD in molecular or cellular biology. A background in developmental haematopoiesis is desirable but not required.

Informal enquiries should be directed to Georges Lacaud

The Cancer Research UK Manchester Institute, an Institute of The University of Manchester, is a world-leading centre for excellence in cancer research. The Institute is core funded by Cancer Research UK, the largest independent cancer research organisation in the world. We are partnered with The Christie NHS Foundation Trust (adjacent to the CRUK Manchester Institute, Paterson Building) in South Manchester, one of the largest cancer treatment centres in Europe. These factors combine to provide an exceptional environment in which to pursue basic, translational and clinical research programmes.

Our aim is to understand the fundamental basis of cancer and apply that knowledge to developing new treatment strategies for cancer patients. Our advanced research programmes span a spectrum of cancer research, from the molecular and cellular basis of cancer through to drug discovery, translational research and clinical trials. The Institute has outstanding laboratory facilities and exceptional core services, including next generation sequencing, microarrays, confocal microscopy, bioinformatics, histology and mass-spectrometry.

To apply for this position please visit our website: www.cruk.manchester.ac.uk
For applicants who are unable to download this information from our website, please contact HR department on 0161 306 0840, email: jobs@cruk.manchester.ac.uk to have this information sent by post.

Closing date: 25 September 2017.
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